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Different outcome of allogeneic transplantation in myelofibrosis using conventional or reduced-intensity conditioning regimens

Merup, Mats; Lazarevic, Vladimir LU ; Nahi, Hareth; Andreasson, Bjorn; Malm, Claes; Nilsson, Lars; Brune, Mats; LeBlanc, Katarina; Kutti, Jack and Birgegard, Gunnar (2006) In British Journal of Haematology 135(3). p.367-373
Abstract
Allogeneic haematopoietic stem cell transplantation remains the only curative treatment of myelofibrosis with myeloid metaplasia (MMM). Previous reports have indicated significant treatment-related mortality (TRM) for patients transplanted after myeloablative conditioning but superior survival has been reported after reduced-intensity conditioning (RIC). We report the results of a survey of all allogeneic transplantations for MMM performed in Sweden at six transplant units between 1982 and 2004. Twenty-seven patients were transplanted; 17 with a myeloablative conditioning regimen and 10 with RIC. The median age was 50 years (5-63 years) at transplantation. After a median follow up of 55 months, 20 patients are alive. TRM was 10% in the RIC... (More)
Allogeneic haematopoietic stem cell transplantation remains the only curative treatment of myelofibrosis with myeloid metaplasia (MMM). Previous reports have indicated significant treatment-related mortality (TRM) for patients transplanted after myeloablative conditioning but superior survival has been reported after reduced-intensity conditioning (RIC). We report the results of a survey of all allogeneic transplantations for MMM performed in Sweden at six transplant units between 1982 and 2004. Twenty-seven patients were transplanted; 17 with a myeloablative conditioning regimen and 10 with RIC. The median age was 50 years (5-63 years) at transplantation. After a median follow up of 55 months, 20 patients are alive. TRM was 10% in the RIC group and 30% in the myeloablative group. There was no difference in survival for high or low-risk patients according to Cervantes score or between sibling and unrelated donor transplantations. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
conditioning, reduced intensity, myelofibrosis, allogeneic transplantation, Cervantes score
in
British Journal of Haematology
volume
135
issue
3
pages
367 - 373
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000240915800012
  • scopus:33749259788
ISSN
0007-1048
DOI
10.1111/j.1365-2141.2006.06302.x
language
English
LU publication?
yes
id
6b419876-233c-4a2d-98c0-ab46d93d7fa7 (old id 389750)
date added to LUP
2007-10-10 12:42:04
date last changed
2019-01-06 06:10:02
@article{6b419876-233c-4a2d-98c0-ab46d93d7fa7,
  abstract     = {Allogeneic haematopoietic stem cell transplantation remains the only curative treatment of myelofibrosis with myeloid metaplasia (MMM). Previous reports have indicated significant treatment-related mortality (TRM) for patients transplanted after myeloablative conditioning but superior survival has been reported after reduced-intensity conditioning (RIC). We report the results of a survey of all allogeneic transplantations for MMM performed in Sweden at six transplant units between 1982 and 2004. Twenty-seven patients were transplanted; 17 with a myeloablative conditioning regimen and 10 with RIC. The median age was 50 years (5-63 years) at transplantation. After a median follow up of 55 months, 20 patients are alive. TRM was 10% in the RIC group and 30% in the myeloablative group. There was no difference in survival for high or low-risk patients according to Cervantes score or between sibling and unrelated donor transplantations.},
  author       = {Merup, Mats and Lazarevic, Vladimir and Nahi, Hareth and Andreasson, Bjorn and Malm, Claes and Nilsson, Lars and Brune, Mats and LeBlanc, Katarina and Kutti, Jack and Birgegard, Gunnar},
  issn         = {0007-1048},
  keyword      = {conditioning,reduced intensity,myelofibrosis,allogeneic transplantation,Cervantes score},
  language     = {eng},
  number       = {3},
  pages        = {367--373},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {British Journal of Haematology},
  title        = {Different outcome of allogeneic transplantation in myelofibrosis using conventional or reduced-intensity conditioning regimens},
  url          = {http://dx.doi.org/10.1111/j.1365-2141.2006.06302.x},
  volume       = {135},
  year         = {2006},
}