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Different outcome of allogeneic transplantation in myelofibrosis using conventional or reduced-intensity conditioning regimens

Merup, Mats ; Lazarevic, Vladimir LU orcid ; Nahi, Hareth ; Andreasson, Bjorn ; Malm, Claes ; Nilsson, Lars ; Brune, Mats ; LeBlanc, Katarina ; Kutti, Jack and Birgegard, Gunnar (2006) In British Journal of Haematology 135(3). p.367-373
Abstract
Allogeneic haematopoietic stem cell transplantation remains the only curative treatment of myelofibrosis with myeloid metaplasia (MMM). Previous reports have indicated significant treatment-related mortality (TRM) for patients transplanted after myeloablative conditioning but superior survival has been reported after reduced-intensity conditioning (RIC). We report the results of a survey of all allogeneic transplantations for MMM performed in Sweden at six transplant units between 1982 and 2004. Twenty-seven patients were transplanted; 17 with a myeloablative conditioning regimen and 10 with RIC. The median age was 50 years (5-63 years) at transplantation. After a median follow up of 55 months, 20 patients are alive. TRM was 10% in the RIC... (More)
Allogeneic haematopoietic stem cell transplantation remains the only curative treatment of myelofibrosis with myeloid metaplasia (MMM). Previous reports have indicated significant treatment-related mortality (TRM) for patients transplanted after myeloablative conditioning but superior survival has been reported after reduced-intensity conditioning (RIC). We report the results of a survey of all allogeneic transplantations for MMM performed in Sweden at six transplant units between 1982 and 2004. Twenty-seven patients were transplanted; 17 with a myeloablative conditioning regimen and 10 with RIC. The median age was 50 years (5-63 years) at transplantation. After a median follow up of 55 months, 20 patients are alive. TRM was 10% in the RIC group and 30% in the myeloablative group. There was no difference in survival for high or low-risk patients according to Cervantes score or between sibling and unrelated donor transplantations. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
conditioning, reduced intensity, myelofibrosis, allogeneic transplantation, Cervantes score
in
British Journal of Haematology
volume
135
issue
3
pages
367 - 373
publisher
John Wiley & Sons Inc.
external identifiers
  • wos:000240915800012
  • scopus:33749259788
ISSN
0007-1048
DOI
10.1111/j.1365-2141.2006.06302.x
language
English
LU publication?
yes
id
6b419876-233c-4a2d-98c0-ab46d93d7fa7 (old id 389750)
date added to LUP
2016-04-01 11:59:32
date last changed
2025-10-14 12:54:53
@article{6b419876-233c-4a2d-98c0-ab46d93d7fa7,
  abstract     = {{Allogeneic haematopoietic stem cell transplantation remains the only curative treatment of myelofibrosis with myeloid metaplasia (MMM). Previous reports have indicated significant treatment-related mortality (TRM) for patients transplanted after myeloablative conditioning but superior survival has been reported after reduced-intensity conditioning (RIC). We report the results of a survey of all allogeneic transplantations for MMM performed in Sweden at six transplant units between 1982 and 2004. Twenty-seven patients were transplanted; 17 with a myeloablative conditioning regimen and 10 with RIC. The median age was 50 years (5-63 years) at transplantation. After a median follow up of 55 months, 20 patients are alive. TRM was 10% in the RIC group and 30% in the myeloablative group. There was no difference in survival for high or low-risk patients according to Cervantes score or between sibling and unrelated donor transplantations.}},
  author       = {{Merup, Mats and Lazarevic, Vladimir and Nahi, Hareth and Andreasson, Bjorn and Malm, Claes and Nilsson, Lars and Brune, Mats and LeBlanc, Katarina and Kutti, Jack and Birgegard, Gunnar}},
  issn         = {{0007-1048}},
  keywords     = {{conditioning; reduced intensity; myelofibrosis; allogeneic transplantation; Cervantes score}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{367--373}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{British Journal of Haematology}},
  title        = {{Different outcome of allogeneic transplantation in myelofibrosis using conventional or reduced-intensity conditioning regimens}},
  url          = {{http://dx.doi.org/10.1111/j.1365-2141.2006.06302.x}},
  doi          = {{10.1111/j.1365-2141.2006.06302.x}},
  volume       = {{135}},
  year         = {{2006}},
}