Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Kirtilkrabbamein í botnlanga á islandi 1990-2009 -- lýdgrundud rannsókn

Vidarsdottir, Halla LU ; Jónasson, Jón Gunnlaugur and Möller, Pall Helgi LU (2011) In Laeknabladid 97(10). p.42-537
Abstract

OBJECTIVE: Adenocarcinoma of the appendix is less than 0.5% of all gastrointestinal cancers. The aim of this study was to analyse the incidence, symptoms, pathology and treatment of appendiceal adenocarcinoma in a well defined cohort as well as the prognosis of the patients.

MATERIALS AND METHODS: This is a retrospective study on all patients diagnosed with adenocarcinoma of the appendix in Iceland from 1990-2009. Information on epidemiological factors, survival and treatment was collected. All histological material was reviewed. Overall survival was estimated with median follow up of 15 months (range, 0-158).

RESULTS: A total of 22 patients were diagnosed with appendiceal adenocarinoma in the study period (median age 63... (More)

OBJECTIVE: Adenocarcinoma of the appendix is less than 0.5% of all gastrointestinal cancers. The aim of this study was to analyse the incidence, symptoms, pathology and treatment of appendiceal adenocarcinoma in a well defined cohort as well as the prognosis of the patients.

MATERIALS AND METHODS: This is a retrospective study on all patients diagnosed with adenocarcinoma of the appendix in Iceland from 1990-2009. Information on epidemiological factors, survival and treatment was collected. All histological material was reviewed. Overall survival was estimated with median follow up of 15 months (range, 0-158).

RESULTS: A total of 22 patients were diagnosed with appendiceal adenocarinoma in the study period (median age 63 yrs, range: 30-88, 50% males). Age-standardized incidence was 0.4/100,000/year. The most common symptom was abdominal pain (n=10). Eight patients had clinical signs of appendicitis. Most patients were diagnosed at operation or at pathological examination but one patient was diagnosed at autopsy. Five patients had an appendectomy and 11 a right hemicolectomy. One patient was not operated on and in three patients only a biopsy was taken. Twelve patients had chemotherapy and seven of them for metastatic disease. Eight patients had adenocarcinoma, seven mucinous adenocarcinoma, three signet ring adenocarcinoma, one mixed goblet cell carcinoid and mucinous adenocarcinoma,one mixed adenocarcinoma and signet ring adenocarcinoma and two a mucinous tumour of unknown malignant potential. In eight cases the tumor originated in adenoma. Most of the patients had a stage IV disease (n=13), three stage III, three stage II and three stage I. Operative mortality was 4.8% (n=1). Disease specific five year survival was 54% but overall five year survival was 44% respectively.

CONCLUSION: Adenocarcinoma of the appendix is a rare disease. No patients were diagnosed pre-operatively. Over half of the patients presented with stage IV disease.

(Less)
Please use this url to cite or link to this publication:
author
; and
organization
alternative title
Adenocarcinoma of the appendix in Iceland 1990-2009. A population based study
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adenocarcinoma, Adult, Aged, Aged, 80 and over, Appendectomy, Appendiceal Neoplasms, Biopsy, Chemotherapy, Adjuvant, Colectomy, Female, Humans, Iceland, Incidence, Male, Middle Aged, Neoplasm Staging, Retrospective Studies, Survival Analysis, Survival Rate, Time Factors, Treatment Outcome, English Abstract, Journal Article
in
Laeknabladid
volume
97
issue
10
pages
6 pages
publisher
Læknafélag Íslands, Læknafélag Reykjavíkur
external identifiers
  • pmid:21998147
  • scopus:80053642566
ISSN
0023-7213
language
Icelandic
LU publication?
yes
id
6bbaf827-ccd3-4b0d-bcf2-c2a3d7343730
date added to LUP
2016-11-17 14:26:34
date last changed
2024-01-04 16:39:20
@article{6bbaf827-ccd3-4b0d-bcf2-c2a3d7343730,
  abstract     = {{<p>OBJECTIVE: Adenocarcinoma of the appendix is less than 0.5% of all gastrointestinal cancers. The aim of this study was to analyse the incidence, symptoms, pathology and treatment of appendiceal adenocarcinoma in a well defined cohort as well as the prognosis of the patients.</p><p>MATERIALS AND METHODS: This is a retrospective study on all patients diagnosed with adenocarcinoma of the appendix in Iceland from 1990-2009. Information on epidemiological factors, survival and treatment was collected. All histological material was reviewed. Overall survival was estimated with median follow up of 15 months (range, 0-158).</p><p>RESULTS: A total of 22 patients were diagnosed with appendiceal adenocarinoma in the study period (median age 63 yrs, range: 30-88, 50% males). Age-standardized incidence was 0.4/100,000/year. The most common symptom was abdominal pain (n=10). Eight patients had clinical signs of appendicitis. Most patients were diagnosed at operation or at pathological examination but one patient was diagnosed at autopsy. Five patients had an appendectomy and 11 a right hemicolectomy. One patient was not operated on and in three patients only a biopsy was taken. Twelve patients had chemotherapy and seven of them for metastatic disease. Eight patients had adenocarcinoma, seven mucinous adenocarcinoma, three signet ring adenocarcinoma, one mixed goblet cell carcinoid and mucinous adenocarcinoma,one mixed adenocarcinoma and signet ring adenocarcinoma and two a mucinous tumour of unknown malignant potential. In eight cases the tumor originated in adenoma. Most of the patients had a stage IV disease (n=13), three stage III, three stage II and three stage I. Operative mortality was 4.8% (n=1). Disease specific five year survival was 54% but overall five year survival was 44% respectively.</p><p>CONCLUSION: Adenocarcinoma of the appendix is a rare disease. No patients were diagnosed pre-operatively. Over half of the patients presented with stage IV disease.</p>}},
  author       = {{Vidarsdottir, Halla and Jónasson, Jón Gunnlaugur and Möller, Pall Helgi}},
  issn         = {{0023-7213}},
  keywords     = {{Adenocarcinoma; Adult; Aged; Aged, 80 and over; Appendectomy; Appendiceal Neoplasms; Biopsy; Chemotherapy, Adjuvant; Colectomy; Female; Humans; Iceland; Incidence; Male; Middle Aged; Neoplasm Staging; Retrospective Studies; Survival Analysis; Survival Rate; Time Factors; Treatment Outcome; English Abstract; Journal Article}},
  language     = {{ice}},
  number       = {{10}},
  pages        = {{42--537}},
  publisher    = {{Læknafélag Íslands, Læknafélag Reykjavíkur}},
  series       = {{Laeknabladid}},
  title        = {{Kirtilkrabbamein í botnlanga á islandi 1990-2009 -- lýdgrundud rannsókn}},
  volume       = {{97}},
  year         = {{2011}},
}