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Fusion of NUP98 and the SET binding protein 1 (SETBP1) gene in a paediatric acute T cell lymphoblastic leukaemia with t(11;18)(p15;q12).

Panagopoulos, Ioannis LU ; Kerndrup, Gitte ; Carlsen, Niels ; Strömbeck, Bodil LU ; Isaksson, Margareth LU and Johansson, Bertil LU (2007) In British Journal of Haematology 136(2). p.294-296
Abstract
Three NUP98 chimaeras have previously been reported in T cell acute lymphoblastic leukaemia (T-ALL): NUP98/ADD3, NUP98/CCDC28A, and NUP98/RAP1GDS1. We report a T-ALL with t(11;18)(p15;q12) resulting in a novel NUP98 fusion. Fluorescent in situ hybridisation showed NUP98 and SET binding protein 1(SETBP1) fusion signals; other analyses showed that exon 12 of NUP98 was fused in-frame with exon 5 of SETBP1. Nested polymerase chain reaction did not amplify the reciprocal SETBP1/NUP98, suggesting that NUP98/SETBP1 transcript is pathogenetically important. SETBP1 has previously not been implicated in leukaemias; however, it encodes a protein that specifically interacts with SET, fused to NUP214 in a case of acute undifferentiated leukaemia.
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Haematology
volume
136
issue
2
pages
294 - 296
publisher
Wiley-Blackwell
external identifiers
  • wos:000243298200013
  • scopus:33845906373
ISSN
0007-1048
DOI
10.1111/j.1365-2141.2006.06410.x
language
English
LU publication?
yes
id
6bc634fe-5ff8-4aa3-8d0c-96ea402b288a (old id 164793)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17233820&dopt=Abstract
date added to LUP
2016-04-01 12:36:59
date last changed
2022-01-27 07:28:29
@article{6bc634fe-5ff8-4aa3-8d0c-96ea402b288a,
  abstract     = {{Three NUP98 chimaeras have previously been reported in T cell acute lymphoblastic leukaemia (T-ALL): NUP98/ADD3, NUP98/CCDC28A, and NUP98/RAP1GDS1. We report a T-ALL with t(11;18)(p15;q12) resulting in a novel NUP98 fusion. Fluorescent in situ hybridisation showed NUP98 and SET binding protein 1(SETBP1) fusion signals; other analyses showed that exon 12 of NUP98 was fused in-frame with exon 5 of SETBP1. Nested polymerase chain reaction did not amplify the reciprocal SETBP1/NUP98, suggesting that NUP98/SETBP1 transcript is pathogenetically important. SETBP1 has previously not been implicated in leukaemias; however, it encodes a protein that specifically interacts with SET, fused to NUP214 in a case of acute undifferentiated leukaemia.}},
  author       = {{Panagopoulos, Ioannis and Kerndrup, Gitte and Carlsen, Niels and Strömbeck, Bodil and Isaksson, Margareth and Johansson, Bertil}},
  issn         = {{0007-1048}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{294--296}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{British Journal of Haematology}},
  title        = {{Fusion of NUP98 and the SET binding protein 1 (SETBP1) gene in a paediatric acute T cell lymphoblastic leukaemia with t(11;18)(p15;q12).}},
  url          = {{http://dx.doi.org/10.1111/j.1365-2141.2006.06410.x}},
  doi          = {{10.1111/j.1365-2141.2006.06410.x}},
  volume       = {{136}},
  year         = {{2007}},
}