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Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention : The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention

McCaffery, Jeanne M. ; Jablonski, Kathleen A. ; Pan, Qing ; Astrup, Arne ; Revsbech Christiansen, Malene ; Corella, Dolores ; Corso, Lauren M.L. ; Florez, Jose C. ; Franks, Paul W. LU and Gardner, Christopher , et al. (2022) In Diabetes 71(4). p.669-676
Abstract

Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with waist circumference (WC) and waist-to-hip ratio (WHR) adjusted for BMI (WCadjBMI and WHRadjBMI), but it remains unclear whether these SNPs relate to change in WCadjBMI or WHRadjBMI with lifestyle intervention for weight loss. We hypothesized that polygenic scores (PS) comprised of 59 SNPs previously associated with central adiposity would predict less of a reduction in WCadjBMI or WHRadjBMI at 8-10 weeks in two lifestyle intervention trials, NUGENOB and DiOGenes, and at 1 year in five lifestyle intervention trials, Look AHEAD, Diabetes Prevention Program, Diabetes Prevention Study, DIETFITS, and PREDIMED-Plus. One-SD higher PS related... (More)

Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with waist circumference (WC) and waist-to-hip ratio (WHR) adjusted for BMI (WCadjBMI and WHRadjBMI), but it remains unclear whether these SNPs relate to change in WCadjBMI or WHRadjBMI with lifestyle intervention for weight loss. We hypothesized that polygenic scores (PS) comprised of 59 SNPs previously associated with central adiposity would predict less of a reduction in WCadjBMI or WHRadjBMI at 8-10 weeks in two lifestyle intervention trials, NUGENOB and DiOGenes, and at 1 year in five lifestyle intervention trials, Look AHEAD, Diabetes Prevention Program, Diabetes Prevention Study, DIETFITS, and PREDIMED-Plus. One-SD higher PS related to a smaller 1-year change in WCadjBMI in the lifestyle intervention arms at year 1 and thus predicted poorer response (β = 0.007; SE = 0.003; P = 0.03) among White participants overall and in White men (β = 0.01; SE = 0.004; P = 0.01). At average weight loss, this amounted to 0.20-0.28 cm per SD. No significant findings emerged in White women or African American men for the 8-10-week outcomes or for WHRadjBMI. Findings were heterogeneous in African American women. These results indicate that polygenic risk estimated from these 59 SNPs relates to change in WCadjBMI with lifestyle intervention, but the effects are small and not of sufficient magnitude to be clinically significant.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes
volume
71
issue
4
pages
8 pages
publisher
American Diabetes Association Inc.
external identifiers
  • scopus:85127999986
  • pmid:35043141
ISSN
1939-327X
DOI
10.2337/db21-0741
language
English
LU publication?
yes
id
6bcbf607-ae3a-45ea-b9af-336a3f7bc45a
date added to LUP
2023-01-20 14:51:31
date last changed
2024-06-13 23:28:50
@article{6bcbf607-ae3a-45ea-b9af-336a3f7bc45a,
  abstract     = {{<p>Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with waist circumference (WC) and waist-to-hip ratio (WHR) adjusted for BMI (WCadjBMI and WHRadjBMI), but it remains unclear whether these SNPs relate to change in WCadjBMI or WHRadjBMI with lifestyle intervention for weight loss. We hypothesized that polygenic scores (PS) comprised of 59 SNPs previously associated with central adiposity would predict less of a reduction in WCadjBMI or WHRadjBMI at 8-10 weeks in two lifestyle intervention trials, NUGENOB and DiOGenes, and at 1 year in five lifestyle intervention trials, Look AHEAD, Diabetes Prevention Program, Diabetes Prevention Study, DIETFITS, and PREDIMED-Plus. One-SD higher PS related to a smaller 1-year change in WCadjBMI in the lifestyle intervention arms at year 1 and thus predicted poorer response (β = 0.007; SE = 0.003; P = 0.03) among White participants overall and in White men (β = 0.01; SE = 0.004; P = 0.01). At average weight loss, this amounted to 0.20-0.28 cm per SD. No significant findings emerged in White women or African American men for the 8-10-week outcomes or for WHRadjBMI. Findings were heterogeneous in African American women. These results indicate that polygenic risk estimated from these 59 SNPs relates to change in WCadjBMI with lifestyle intervention, but the effects are small and not of sufficient magnitude to be clinically significant.</p>}},
  author       = {{McCaffery, Jeanne M. and Jablonski, Kathleen A. and Pan, Qing and Astrup, Arne and Revsbech Christiansen, Malene and Corella, Dolores and Corso, Lauren M.L. and Florez, Jose C. and Franks, Paul W. and Gardner, Christopher and Hansen, Torben and Kilpeläinen, Tuomas O. and Knowler, William C. and Lindström, Jaana and Saris, Wim H.M. and Sørensen, Thorkild I.A. and Tuomilehto, Jaakko and Uusitupa, Matti and Wing, Rena R. and Agurs-Collins, Tanya}},
  issn         = {{1939-327X}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{4}},
  pages        = {{669--676}},
  publisher    = {{American Diabetes Association Inc.}},
  series       = {{Diabetes}},
  title        = {{Genetic Predictors of Change in Waist Circumference and Waist-to-Hip Ratio With Lifestyle Intervention : The Trans-NIH Consortium for Genetics of Weight Loss Response to Lifestyle Intervention}},
  url          = {{http://dx.doi.org/10.2337/db21-0741}},
  doi          = {{10.2337/db21-0741}},
  volume       = {{71}},
  year         = {{2022}},
}