Vitamin D and Osteogenesis Imperfecta in Pediatrics
(2023) In Pharmaceuticals 16(5).- Abstract
Osteogenesis Imperfecta (OI) is a heterogeneous group of inherited skeletal dysplasias characterized by bone fragility. The study of bone metabolism, in these disease, is problematic in terms of clinical and genetic variability. The aims of our study were to evaluate the importance of Vitamin D levels in OI bone metabolism, reviewing studies performed on this topic and providing advice reflecting our experience using vitamin D supplementation. A comprehensive review on all English-language articles was conducted in order to analyze the influence of vitamin D in OI bone metabolism in pediatric patients. Reviewing the studies, contradictory data were found on the relationship between 25OH vitamin D levels and bone parameters in OI, and in... (More)
Osteogenesis Imperfecta (OI) is a heterogeneous group of inherited skeletal dysplasias characterized by bone fragility. The study of bone metabolism, in these disease, is problematic in terms of clinical and genetic variability. The aims of our study were to evaluate the importance of Vitamin D levels in OI bone metabolism, reviewing studies performed on this topic and providing advice reflecting our experience using vitamin D supplementation. A comprehensive review on all English-language articles was conducted in order to analyze the influence of vitamin D in OI bone metabolism in pediatric patients. Reviewing the studies, contradictory data were found on the relationship between 25OH vitamin D levels and bone parameters in OI, and in several studies the baseline levels of 25OH D were below the threshold value of 75 nmol/L. In conclusion, according to the literature and to our experience, we highlight the importance of adequate vitamin D supplementation in children with OI.
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- author
- Coccia, Francesco ; Pietrobelli, Angelo ; Zoller, Thomas ; Guzzo, Alessandra ; Cavarzere, Paolo ; Fassio, Angelo ; Flodmark, Carl Erik LU ; Gatti, Davide and Antoniazzi, Franco
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- osteogenesis imperfecta, pediatrics, vitamin D
- in
- Pharmaceuticals
- volume
- 16
- issue
- 5
- article number
- 690
- publisher
- MDPI AG
- external identifiers
-
- pmid:37242473
- scopus:85160653970
- ISSN
- 1424-8247
- DOI
- 10.3390/ph16050690
- language
- English
- LU publication?
- yes
- id
- 6bd2ed1b-05ac-4413-8def-3a5d7a0f0c63
- date added to LUP
- 2023-08-22 13:28:02
- date last changed
- 2024-09-08 13:30:06
@article{6bd2ed1b-05ac-4413-8def-3a5d7a0f0c63, abstract = {{<p>Osteogenesis Imperfecta (OI) is a heterogeneous group of inherited skeletal dysplasias characterized by bone fragility. The study of bone metabolism, in these disease, is problematic in terms of clinical and genetic variability. The aims of our study were to evaluate the importance of Vitamin D levels in OI bone metabolism, reviewing studies performed on this topic and providing advice reflecting our experience using vitamin D supplementation. A comprehensive review on all English-language articles was conducted in order to analyze the influence of vitamin D in OI bone metabolism in pediatric patients. Reviewing the studies, contradictory data were found on the relationship between 25OH vitamin D levels and bone parameters in OI, and in several studies the baseline levels of 25OH D were below the threshold value of 75 nmol/L. In conclusion, according to the literature and to our experience, we highlight the importance of adequate vitamin D supplementation in children with OI.</p>}}, author = {{Coccia, Francesco and Pietrobelli, Angelo and Zoller, Thomas and Guzzo, Alessandra and Cavarzere, Paolo and Fassio, Angelo and Flodmark, Carl Erik and Gatti, Davide and Antoniazzi, Franco}}, issn = {{1424-8247}}, keywords = {{osteogenesis imperfecta; pediatrics; vitamin D}}, language = {{eng}}, number = {{5}}, publisher = {{MDPI AG}}, series = {{Pharmaceuticals}}, title = {{Vitamin D and Osteogenesis Imperfecta in Pediatrics}}, url = {{http://dx.doi.org/10.3390/ph16050690}}, doi = {{10.3390/ph16050690}}, volume = {{16}}, year = {{2023}}, }