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Intraindividual hormonal variability in ultrasonographically timed successive ovulatory menstrual cycles is detected only in the luteal phase in infertility patients

Ojha, Kamal; Barnes, Sophie C; Boa, Frances G; Moody, Stephen; Sladkevicius, Povilas LU ; Nargund, Geeta and Collinson, Paul O (2002) In Journal of Assisted Reproduction and Genetics 19(8). p.7-363
Abstract

OBJECTIVE: To assess intraindividual variation of follicle stimulating hormone, luteinising hormone, estradiol, progesterone, inhibin A, and inhibin B in three successive ovulatory cycles correlated with transvaginal ultrasound monitored morphological changes in the ovary.

METHODS: Serial transvaginal color and pulsed Doppler ultrasound and serum hormone analysis were performed during midfollicular, periovulatory, and midluteal phase for three consecutive cycles in 19 patients with normal menstrual cycles.

RESULTS: Luteinising hormone and progesterone showed significant differences in the midluteal phase between the 1st and 2nd cycle (luteinising hormone p = 0.007 and progesterone p = 0.02). Progesterone showed a similar... (More)

OBJECTIVE: To assess intraindividual variation of follicle stimulating hormone, luteinising hormone, estradiol, progesterone, inhibin A, and inhibin B in three successive ovulatory cycles correlated with transvaginal ultrasound monitored morphological changes in the ovary.

METHODS: Serial transvaginal color and pulsed Doppler ultrasound and serum hormone analysis were performed during midfollicular, periovulatory, and midluteal phase for three consecutive cycles in 19 patients with normal menstrual cycles.

RESULTS: Luteinising hormone and progesterone showed significant differences in the midluteal phase between the 1st and 2nd cycle (luteinising hormone p = 0.007 and progesterone p = 0.02). Progesterone showed a similar significant change (p = 0.013) between the 2nd and 3rd cycle. No significant differences were seen in the midfollicular or periovulatory phases or between the 1st and 3rd cycle.

CONCLUSIONS: Luteal phase progesterone and luteinising hormone concentrations showed individual variation in successive cycles suggesting early or late corpus luteolysis. Follicular and periovulatory hormone levels were similar in subsequent ovulatory cycles.

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keywords
Adult, Estradiol, Female, Follicle Stimulating Hormone, Gonadal Steroid Hormones, Humans, Infertility, Inhibins, Luteal Phase, Luteinizing Hormone, Menstrual Cycle, Ovarian Follicle, Progesterone, Prospective Studies, Statistics, Nonparametric, Ultrasonography, Doppler, Color, Ultrasonography, Doppler, Pulsed, gynekologi, reproduktion, könshormoner
in
Journal of Assisted Reproduction and Genetics
volume
19
issue
8
pages
5 pages
publisher
Kluwer
external identifiers
  • scopus:0035988587
ISSN
1058-0468
DOI
10.1023/A:1016342320269
language
English
LU publication?
yes
id
6bed1e0a-7720-43d2-a199-4f7936ebec45
date added to LUP
2016-06-09 09:40:38
date last changed
2017-01-01 08:27:45
@article{6bed1e0a-7720-43d2-a199-4f7936ebec45,
  abstract     = {<p>OBJECTIVE: To assess intraindividual variation of follicle stimulating hormone, luteinising hormone, estradiol, progesterone, inhibin A, and inhibin B in three successive ovulatory cycles correlated with transvaginal ultrasound monitored morphological changes in the ovary.</p><p>METHODS: Serial transvaginal color and pulsed Doppler ultrasound and serum hormone analysis were performed during midfollicular, periovulatory, and midluteal phase for three consecutive cycles in 19 patients with normal menstrual cycles.</p><p>RESULTS: Luteinising hormone and progesterone showed significant differences in the midluteal phase between the 1st and 2nd cycle (luteinising hormone p = 0.007 and progesterone p = 0.02). Progesterone showed a similar significant change (p = 0.013) between the 2nd and 3rd cycle. No significant differences were seen in the midfollicular or periovulatory phases or between the 1st and 3rd cycle.</p><p>CONCLUSIONS: Luteal phase progesterone and luteinising hormone concentrations showed individual variation in successive cycles suggesting early or late corpus luteolysis. Follicular and periovulatory hormone levels were similar in subsequent ovulatory cycles.</p>},
  author       = {Ojha, Kamal and Barnes, Sophie C and Boa, Frances G and Moody, Stephen and Sladkevicius, Povilas and Nargund, Geeta and Collinson, Paul O},
  issn         = {1058-0468},
  keyword      = {Adult,Estradiol,Female,Follicle Stimulating Hormone,Gonadal Steroid Hormones,Humans,Infertility,Inhibins,Luteal Phase,Luteinizing Hormone,Menstrual Cycle,Ovarian Follicle,Progesterone,Prospective Studies,Statistics, Nonparametric,Ultrasonography, Doppler, Color,Ultrasonography, Doppler, Pulsed,gynekologi,reproduktion,könshormoner},
  language     = {eng},
  number       = {8},
  pages        = {7--363},
  publisher    = {Kluwer},
  series       = {Journal of Assisted Reproduction and Genetics},
  title        = {Intraindividual hormonal variability in ultrasonographically timed successive ovulatory menstrual cycles is detected only in the luteal phase in infertility patients},
  url          = {http://dx.doi.org/10.1023/A:1016342320269},
  volume       = {19},
  year         = {2002},
}