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Plasma calprotectin in the emergency department : a potential clinical biomarker for patients with infectious diseases

Wollmer, Martin LU ; Wändell, Per LU ; Rosenqvist, Mari LU ; Larsson, Anders ; Melander, Olle LU orcid ; Wessman, Torgny LU ; Ärnlöv, Johan and Ruge, Toralph LU (2021) In Scandinavian Journal of Clinical and Laboratory Investigation 81(7). p.593-597
Abstract

Increased levels of plasma calprotectin are reported in patients with infectious diseases. However, the clinical usefulness of calprotectin as a biomarker to identify patients with infectious diseases in the emergency department (ED) setting has not been investigated. To study the ability of calprotectin to discriminate patients with acute infectious diseases and dyspnea from patients with other causes of acute dyspnea in the ED setting. Patients aged ≥18 years seeking ED during daytime on weekdays between March 2013 and July 2018, with acute dyspnea, were included. Participants (n = 1287) were triaged according to Medical Emergency Triage and Treatment System-Adult score (METTS-A) or Rapid Emergency Triage and Treatment System (RETTS),... (More)

Increased levels of plasma calprotectin are reported in patients with infectious diseases. However, the clinical usefulness of calprotectin as a biomarker to identify patients with infectious diseases in the emergency department (ED) setting has not been investigated. To study the ability of calprotectin to discriminate patients with acute infectious diseases and dyspnea from patients with other causes of acute dyspnea in the ED setting. Patients aged ≥18 years seeking ED during daytime on weekdays between March 2013 and July 2018, with acute dyspnea, were included. Participants (n = 1287) were triaged according to Medical Emergency Triage and Treatment System-Adult score (METTS-A) or Rapid Emergency Triage and Treatment System (RETTS), and blood samples were collected. The association between calprotectin and other markers of infectious diseases, i.e. biomarkers (CRP, leucocytes) and body temperature, was studied. The predictive value of calprotectin for the outcome of acute infection was evaluated with receiver operating characteristic (ROC) analysis. Univariate cross-sectional regression showed significant associations between calprotectin and leucocytes, CRP and body temperature. Patients with severe infections including pneumonia (n = 119) had significantly higher concentrations of calprotectin compared to patients with heart failure (n = 162) or chronic obstructive pulmonary disease (n = 183). When tested for the outcome of acute infection (n = 109), the area under the ROC curve (AUROC) was for CRP 0.83 and for calprotectin 0.78. Plasma calprotectin identifies infectious diseases in ED patients with acute dyspnea, and the clinical usefulness of Calprotectin in the ED has to be further studied.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
C-reactive protein, communicable diseases, dyspnea, Emergency service, hospital, leukocyte L1 antigen complex (calprotectin), predictive value of tests
in
Scandinavian Journal of Clinical and Laboratory Investigation
volume
81
issue
7
pages
593 - 597
publisher
Informa Healthcare
external identifiers
  • scopus:85115351759
  • pmid:34553669
ISSN
0036-5513
DOI
10.1080/00365513.2021.1980223
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
id
6c230a7e-07ad-45ee-b927-dd9c9a8d30f8
date added to LUP
2021-10-25 15:57:14
date last changed
2024-07-13 21:31:01
@article{6c230a7e-07ad-45ee-b927-dd9c9a8d30f8,
  abstract     = {{<p>Increased levels of plasma calprotectin are reported in patients with infectious diseases. However, the clinical usefulness of calprotectin as a biomarker to identify patients with infectious diseases in the emergency department (ED) setting has not been investigated. To study the ability of calprotectin to discriminate patients with acute infectious diseases and dyspnea from patients with other causes of acute dyspnea in the ED setting. Patients aged ≥18 years seeking ED during daytime on weekdays between March 2013 and July 2018, with acute dyspnea, were included. Participants (n = 1287) were triaged according to Medical Emergency Triage and Treatment System-Adult score (METTS-A) or Rapid Emergency Triage and Treatment System (RETTS), and blood samples were collected. The association between calprotectin and other markers of infectious diseases, i.e. biomarkers (CRP, leucocytes) and body temperature, was studied. The predictive value of calprotectin for the outcome of acute infection was evaluated with receiver operating characteristic (ROC) analysis. Univariate cross-sectional regression showed significant associations between calprotectin and leucocytes, CRP and body temperature. Patients with severe infections including pneumonia (n = 119) had significantly higher concentrations of calprotectin compared to patients with heart failure (n = 162) or chronic obstructive pulmonary disease (n = 183). When tested for the outcome of acute infection (n = 109), the area under the ROC curve (AUROC) was for CRP 0.83 and for calprotectin 0.78. Plasma calprotectin identifies infectious diseases in ED patients with acute dyspnea, and the clinical usefulness of Calprotectin in the ED has to be further studied.</p>}},
  author       = {{Wollmer, Martin and Wändell, Per and Rosenqvist, Mari and Larsson, Anders and Melander, Olle and Wessman, Torgny and Ärnlöv, Johan and Ruge, Toralph}},
  issn         = {{0036-5513}},
  keywords     = {{C-reactive protein; communicable diseases; dyspnea; Emergency service; hospital; leukocyte L1 antigen complex (calprotectin); predictive value of tests}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{593--597}},
  publisher    = {{Informa Healthcare}},
  series       = {{Scandinavian Journal of Clinical and Laboratory Investigation}},
  title        = {{Plasma calprotectin in the emergency department : a potential clinical biomarker for patients with infectious diseases}},
  url          = {{http://dx.doi.org/10.1080/00365513.2021.1980223}},
  doi          = {{10.1080/00365513.2021.1980223}},
  volume       = {{81}},
  year         = {{2021}},
}