Inhibitory effects of the sesquiterpene T‐cadinol on contractile responses in the isolated guinea‐pig ileum
(1991) In Phytotherapy Research 5(3). p.142-144- Abstract
The smooth muscle relaxing effect of the sesquiterpene T‐cadinol, isolated from scented myrrh (resin of Commiphora guidottii Chiov., Burseraceae), was investigated. The compound inhibited the contractile responses in the isolated guinea‐pig ileum to histamine, carbachol, Ba2+ and K+ in a concentration dependent and reversible manner. The antagonism of the receptor‐mediated contractions induced by histamine and carbachol was not of a competitive type. The contractions induced by Ba2+‐ and K+ were somewhat more sensitive to the action of T‐cadinol than the receptor mediated contractions. It is suggested that the compound may interfere with a step of the contraction sequence common to all four... (More)
The smooth muscle relaxing effect of the sesquiterpene T‐cadinol, isolated from scented myrrh (resin of Commiphora guidottii Chiov., Burseraceae), was investigated. The compound inhibited the contractile responses in the isolated guinea‐pig ileum to histamine, carbachol, Ba2+ and K+ in a concentration dependent and reversible manner. The antagonism of the receptor‐mediated contractions induced by histamine and carbachol was not of a competitive type. The contractions induced by Ba2+‐ and K+ were somewhat more sensitive to the action of T‐cadinol than the receptor mediated contractions. It is suggested that the compound may interfere with a step of the contraction sequence common to all four spasmogens.
(Less)
- author
- Zygmunt, Peter LU and Claeson, Per
- publishing date
- 1991-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Burseraceae, Commiphora guidottii, guinea‐pig ileum, sesquiterpene, smooth muscle relaxing effect, T‐cadinol
- in
- Phytotherapy Research
- volume
- 5
- issue
- 3
- pages
- 3 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:0025829183
- ISSN
- 0951-418X
- DOI
- 10.1002/ptr.2650050312
- language
- English
- LU publication?
- no
- id
- 6c3a62ae-722e-420f-8b0f-57e47b1de8b4
- date added to LUP
- 2019-05-31 21:43:30
- date last changed
- 2021-01-03 09:34:00
@misc{6c3a62ae-722e-420f-8b0f-57e47b1de8b4, abstract = {{<p>The smooth muscle relaxing effect of the sesquiterpene T‐cadinol, isolated from scented myrrh (resin of Commiphora guidottii Chiov., Burseraceae), was investigated. The compound inhibited the contractile responses in the isolated guinea‐pig ileum to histamine, carbachol, Ba<sup>2+</sup> and K<sup>+</sup> in a concentration dependent and reversible manner. The antagonism of the receptor‐mediated contractions induced by histamine and carbachol was not of a competitive type. The contractions induced by Ba<sup>2+</sup>‐ and K<sup>+</sup> were somewhat more sensitive to the action of T‐cadinol than the receptor mediated contractions. It is suggested that the compound may interfere with a step of the contraction sequence common to all four spasmogens.</p>}}, author = {{Zygmunt, Peter and Claeson, Per}}, issn = {{0951-418X}}, keywords = {{Burseraceae; Commiphora guidottii; guinea‐pig ileum; sesquiterpene; smooth muscle relaxing effect; T‐cadinol}}, language = {{eng}}, number = {{3}}, pages = {{142--144}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Phytotherapy Research}}, title = {{Inhibitory effects of the sesquiterpene T‐cadinol on contractile responses in the isolated guinea‐pig ileum}}, url = {{http://dx.doi.org/10.1002/ptr.2650050312}}, doi = {{10.1002/ptr.2650050312}}, volume = {{5}}, year = {{1991}}, }