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Inhibitory effects of the sesquiterpene T‐cadinol on contractile responses in the isolated guinea‐pig ileum

Zygmunt, Peter LU orcid and Claeson, Per (1991) In Phytotherapy Research 5(3). p.142-144
Abstract

The smooth muscle relaxing effect of the sesquiterpene T‐cadinol, isolated from scented myrrh (resin of Commiphora guidottii Chiov., Burseraceae), was investigated. The compound inhibited the contractile responses in the isolated guinea‐pig ileum to histamine, carbachol, Ba2+ and K+ in a concentration dependent and reversible manner. The antagonism of the receptor‐mediated contractions induced by histamine and carbachol was not of a competitive type. The contractions induced by Ba2+‐ and K+ were somewhat more sensitive to the action of T‐cadinol than the receptor mediated contractions. It is suggested that the compound may interfere with a step of the contraction sequence common to all four... (More)

The smooth muscle relaxing effect of the sesquiterpene T‐cadinol, isolated from scented myrrh (resin of Commiphora guidottii Chiov., Burseraceae), was investigated. The compound inhibited the contractile responses in the isolated guinea‐pig ileum to histamine, carbachol, Ba2+ and K+ in a concentration dependent and reversible manner. The antagonism of the receptor‐mediated contractions induced by histamine and carbachol was not of a competitive type. The contractions induced by Ba2+‐ and K+ were somewhat more sensitive to the action of T‐cadinol than the receptor mediated contractions. It is suggested that the compound may interfere with a step of the contraction sequence common to all four spasmogens.

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author
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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Burseraceae, Commiphora guidottii, guinea‐pig ileum, sesquiterpene, smooth muscle relaxing effect, T‐cadinol
in
Phytotherapy Research
volume
5
issue
3
pages
3 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:0025829183
ISSN
0951-418X
DOI
10.1002/ptr.2650050312
language
English
LU publication?
no
id
6c3a62ae-722e-420f-8b0f-57e47b1de8b4
date added to LUP
2019-05-31 21:43:30
date last changed
2021-01-03 09:34:00
@misc{6c3a62ae-722e-420f-8b0f-57e47b1de8b4,
  abstract     = {{<p>The smooth muscle relaxing effect of the sesquiterpene T‐cadinol, isolated from scented myrrh (resin of Commiphora guidottii Chiov., Burseraceae), was investigated. The compound inhibited the contractile responses in the isolated guinea‐pig ileum to histamine, carbachol, Ba<sup>2+</sup> and K<sup>+</sup> in a concentration dependent and reversible manner. The antagonism of the receptor‐mediated contractions induced by histamine and carbachol was not of a competitive type. The contractions induced by Ba<sup>2+</sup>‐ and K<sup>+</sup> were somewhat more sensitive to the action of T‐cadinol than the receptor mediated contractions. It is suggested that the compound may interfere with a step of the contraction sequence common to all four spasmogens.</p>}},
  author       = {{Zygmunt, Peter and Claeson, Per}},
  issn         = {{0951-418X}},
  keywords     = {{Burseraceae; Commiphora guidottii; guinea‐pig ileum; sesquiterpene; smooth muscle relaxing effect; T‐cadinol}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{142--144}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Phytotherapy Research}},
  title        = {{Inhibitory effects of the sesquiterpene T‐cadinol on contractile responses in the isolated guinea‐pig ileum}},
  url          = {{http://dx.doi.org/10.1002/ptr.2650050312}},
  doi          = {{10.1002/ptr.2650050312}},
  volume       = {{5}},
  year         = {{1991}},
}