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Novel approaches to the stratified management of knee osteoarthritis

Fuggle, Nicholas R. ; Chapurlat, Roland ; Laslop, Andrea ; Al-Daghri, Nasser ; Alokail, Majed ; Thiyagarajan, Jotheeswaran Amuthavalli ; Balkowiec-Iskra, Ewa ; Berenbaum, Francis ; Bemden, Angie Botto van and Borg, John Joseph , et al. (2025) In Nature Reviews Rheumatology 21(11). p.684-695
Abstract

Knee osteoarthritis is a highly prevalent whole-joint disease that is associated with substantial morbidity. If step changes are to be made in the management of knee osteoarthritis, novel patient stratification approaches are needed to identify the most effective treatment for individual patients. Numerous methods for stratifying patients with knee osteoarthritis can be employed; clinical presentation, including co-morbidity and pain phenotype, can influence treatment decisions, and there is a rich history of imaging biomarker use, both from conventional radiographs and, since its development, via MRI, in identifying patients at risk of disease progression, and the latter facilitates the detection of synovitis. The development of novel... (More)

Knee osteoarthritis is a highly prevalent whole-joint disease that is associated with substantial morbidity. If step changes are to be made in the management of knee osteoarthritis, novel patient stratification approaches are needed to identify the most effective treatment for individual patients. Numerous methods for stratifying patients with knee osteoarthritis can be employed; clinical presentation, including co-morbidity and pain phenotype, can influence treatment decisions, and there is a rich history of imaging biomarker use, both from conventional radiographs and, since its development, via MRI, in identifying patients at risk of disease progression, and the latter facilitates the detection of synovitis. The development of novel biochemical biomarkers and the rapid growth of ‘-omics’ technologies provide fresh opportunities to deploy these advances in the stratification of patients with knee osteoarthritis. The health economic landscape in this area is developing, and scoping work has highlighted the need for further studies.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews Rheumatology
volume
21
issue
11
pages
12 pages
publisher
Nature Publishing Group
external identifiers
  • pmid:41044417
  • scopus:105018510203
ISSN
1759-4790
DOI
10.1038/s41584-025-01305-x
language
English
LU publication?
yes
additional info
Publisher Copyright: © Springer Nature Limited 2025.
id
6c5015d8-224a-4fc9-a3f3-d39f83c8bd82
date added to LUP
2025-12-17 10:39:03
date last changed
2025-12-18 06:37:49
@article{6c5015d8-224a-4fc9-a3f3-d39f83c8bd82,
  abstract     = {{<p>Knee osteoarthritis is a highly prevalent whole-joint disease that is associated with substantial morbidity. If step changes are to be made in the management of knee osteoarthritis, novel patient stratification approaches are needed to identify the most effective treatment for individual patients. Numerous methods for stratifying patients with knee osteoarthritis can be employed; clinical presentation, including co-morbidity and pain phenotype, can influence treatment decisions, and there is a rich history of imaging biomarker use, both from conventional radiographs and, since its development, via MRI, in identifying patients at risk of disease progression, and the latter facilitates the detection of synovitis. The development of novel biochemical biomarkers and the rapid growth of ‘-omics’ technologies provide fresh opportunities to deploy these advances in the stratification of patients with knee osteoarthritis. The health economic landscape in this area is developing, and scoping work has highlighted the need for further studies.</p>}},
  author       = {{Fuggle, Nicholas R. and Chapurlat, Roland and Laslop, Andrea and Al-Daghri, Nasser and Alokail, Majed and Thiyagarajan, Jotheeswaran Amuthavalli and Balkowiec-Iskra, Ewa and Berenbaum, Francis and Bemden, Angie Botto van and Borg, John Joseph and Bruyère, Olivier and Burlet, Nansa and Cavalier, Etienne and Rosa, Mario M. and Conaghan, Philip G. and Cooper, Cyrus and Dennison, Elaine M. and Englund, Martin and Im, Gun Il and Haugen, Ida K. and Hiligsmann, Mickaël and Kurth, Andreas and Lane, Nancy and Lories, Rik and Marlovits, Stefan and Matijevic, Radmila and Mobasheri, Ali and Ormarsdóttir, Sif and Yerro, Maria C.Prieto and Radermecker, Régis P. and Rannou, François and Sepodes, Bruno and Silverman, Stuart and Torre, Carla and Veronese, Nicola and Rizzoli, René and Reginster, Jean Yves and Harvey, Nicholas C.}},
  issn         = {{1759-4790}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{684--695}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Reviews Rheumatology}},
  title        = {{Novel approaches to the stratified management of knee osteoarthritis}},
  url          = {{http://dx.doi.org/10.1038/s41584-025-01305-x}},
  doi          = {{10.1038/s41584-025-01305-x}},
  volume       = {{21}},
  year         = {{2025}},
}