Lifestyle interventions for the prevention and treatment of hypertension
(2021) In Nature Reviews Cardiology 18(4). p.251-275- Abstract
Hypertension affects approximately one third of the world’s adult population and is a major cause of premature death despite considerable advances in pharmacological treatments. Growing evidence supports the use of lifestyle interventions for the prevention and adjuvant treatment of hypertension. In this Review, we provide a summary of the epidemiological research supporting the preventive and antihypertensive effects of major lifestyle interventions (regular physical exercise, body weight management and healthy dietary patterns), as well as other less traditional recommendations such as stress management and the promotion of adequate sleep patterns coupled with circadian entrainment. We also discuss the physiological mechanisms... (More)
Hypertension affects approximately one third of the world’s adult population and is a major cause of premature death despite considerable advances in pharmacological treatments. Growing evidence supports the use of lifestyle interventions for the prevention and adjuvant treatment of hypertension. In this Review, we provide a summary of the epidemiological research supporting the preventive and antihypertensive effects of major lifestyle interventions (regular physical exercise, body weight management and healthy dietary patterns), as well as other less traditional recommendations such as stress management and the promotion of adequate sleep patterns coupled with circadian entrainment. We also discuss the physiological mechanisms underlying the beneficial effects of these lifestyle interventions on hypertension, which include not only the prevention of traditional risk factors (such as obesity and insulin resistance) and improvements in vascular health through an improved redox and inflammatory status, but also reduced sympathetic overactivation and non-traditional mechanisms such as increased secretion of myokines.
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- author
- Valenzuela, Pedro L. ; Carrera-Bastos, Pedro LU ; Gálvez, Beatriz G. ; Ruiz-Hurtado, Gema ; Ordovas, José M. ; Ruilope, Luis M. and Lucia, Alejandro
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Reviews Cardiology
- volume
- 18
- issue
- 4
- pages
- 251 - 275
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85092407944
- pmid:33037326
- ISSN
- 1759-5002
- DOI
- 10.1038/s41569-020-00437-9
- language
- English
- LU publication?
- yes
- id
- 6c776b10-88f8-4659-993c-61ac4ed03f87
- date added to LUP
- 2020-11-03 11:35:04
- date last changed
- 2024-06-14 01:23:19
@article{6c776b10-88f8-4659-993c-61ac4ed03f87,
abstract = {{<p>Hypertension affects approximately one third of the world’s adult population and is a major cause of premature death despite considerable advances in pharmacological treatments. Growing evidence supports the use of lifestyle interventions for the prevention and adjuvant treatment of hypertension. In this Review, we provide a summary of the epidemiological research supporting the preventive and antihypertensive effects of major lifestyle interventions (regular physical exercise, body weight management and healthy dietary patterns), as well as other less traditional recommendations such as stress management and the promotion of adequate sleep patterns coupled with circadian entrainment. We also discuss the physiological mechanisms underlying the beneficial effects of these lifestyle interventions on hypertension, which include not only the prevention of traditional risk factors (such as obesity and insulin resistance) and improvements in vascular health through an improved redox and inflammatory status, but also reduced sympathetic overactivation and non-traditional mechanisms such as increased secretion of myokines.</p>}},
author = {{Valenzuela, Pedro L. and Carrera-Bastos, Pedro and Gálvez, Beatriz G. and Ruiz-Hurtado, Gema and Ordovas, José M. and Ruilope, Luis M. and Lucia, Alejandro}},
issn = {{1759-5002}},
language = {{eng}},
number = {{4}},
pages = {{251--275}},
publisher = {{Nature Publishing Group}},
series = {{Nature Reviews Cardiology}},
title = {{Lifestyle interventions for the prevention and treatment of hypertension}},
url = {{http://dx.doi.org/10.1038/s41569-020-00437-9}},
doi = {{10.1038/s41569-020-00437-9}},
volume = {{18}},
year = {{2021}},
}