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First-line Aspiration Thrombectomy with the RED43 Catheter for Acute Ischemic Stroke due to Medium or Distal Vessel Occlusion

Aebischer, Vera ; Brehm, Alex ; Rommers, Nikki ; Spiotta, Alejandro ; Sowlat, Mohammad ; Raghuram, Karthik ; Cappuzzo, Justin M ; Beecher, Jeffrey ; Matouk, Charles and Amllay, Abdelaziz , et al. (2025) In Clinical Neuroradiology
Abstract

PURPOSE: Techniques for endovascular thrombectomy in acute ischemic stroke due to medium or distal vessel occlusions (MDVO) need to be improved, and first-line aspiration is emerging as a promising technique. The objective was to describe first-pass and final reperfusion rates with a triaxial direct aspiration first pass technique (ADAPT) and a novel, quadriaxial technique (QUATTRO-ADAPT) using RED43 Reperfusion Catheters to target MDVOs.

METHODS: This retrospective study collected data from 11 stroke centers in Europe and North America between 2023 and 2025. Patients with primary, isolated MDVOs who underwent thrombectomy using first-line aspiration with RED43 Reperfusion Catheters were included. Primary outcome was first-pass... (More)

PURPOSE: Techniques for endovascular thrombectomy in acute ischemic stroke due to medium or distal vessel occlusions (MDVO) need to be improved, and first-line aspiration is emerging as a promising technique. The objective was to describe first-pass and final reperfusion rates with a triaxial direct aspiration first pass technique (ADAPT) and a novel, quadriaxial technique (QUATTRO-ADAPT) using RED43 Reperfusion Catheters to target MDVOs.

METHODS: This retrospective study collected data from 11 stroke centers in Europe and North America between 2023 and 2025. Patients with primary, isolated MDVOs who underwent thrombectomy using first-line aspiration with RED43 Reperfusion Catheters were included. Primary outcome was first-pass successful reperfusion rate (modified Treatment In Cerebral Infarction score ≥ 2b). Additionally, final reperfusion rates, complications and functional outcomes up to 90 days were evaluated.

RESULTS: We included 85 cases. Median age was 74 years (IQR 67-81) and median National Institutes of Health Stroke Scale score 9 (IQR 6-15). The majority (69.4%) had an occlusion of the co- or nondominant M2 segment of the middle cerebral artery. First-pass successful reperfusion was 63.5% overall, with 55.6% for the triaxial ADAPT and 69.4% for the quadriaxial QUATTRO-ADAPT. Final successful reperfusion was achieved in 96.5%. Complications included vessel perforations (2.4%), subarachnoid hemorrhage (3.5%), parenchymal hematoma type 2 (2.4%), and symptomatic intracerebral hemorrhage (1.2%). Functional independence (modified Rankin Scale 0-2) at 90 days was observed in 58.7%.

CONCLUSION: This study shows that first-line aspiration, especially in a quadriaxial approach, can be effective and safe. These findings should be evaluated in prospective trials.

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Please use this url to cite or link to this publication:
@article{6c87374c-5673-48eb-9ca7-45655ee626b8,
  abstract     = {{<p>PURPOSE: Techniques for endovascular thrombectomy in acute ischemic stroke due to medium or distal vessel occlusions (MDVO) need to be improved, and first-line aspiration is emerging as a promising technique. The objective was to describe first-pass and final reperfusion rates with a triaxial direct aspiration first pass technique (ADAPT) and a novel, quadriaxial technique (QUATTRO-ADAPT) using RED43 Reperfusion Catheters to target MDVOs.</p><p>METHODS: This retrospective study collected data from 11 stroke centers in Europe and North America between 2023 and 2025. Patients with primary, isolated MDVOs who underwent thrombectomy using first-line aspiration with RED43 Reperfusion Catheters were included. Primary outcome was first-pass successful reperfusion rate (modified Treatment In Cerebral Infarction score ≥ 2b). Additionally, final reperfusion rates, complications and functional outcomes up to 90 days were evaluated.</p><p>RESULTS: We included 85 cases. Median age was 74 years (IQR 67-81) and median National Institutes of Health Stroke Scale score 9 (IQR 6-15). The majority (69.4%) had an occlusion of the co- or nondominant M2 segment of the middle cerebral artery. First-pass successful reperfusion was 63.5% overall, with 55.6% for the triaxial ADAPT and 69.4% for the quadriaxial QUATTRO-ADAPT. Final successful reperfusion was achieved in 96.5%. Complications included vessel perforations (2.4%), subarachnoid hemorrhage (3.5%), parenchymal hematoma type 2 (2.4%), and symptomatic intracerebral hemorrhage (1.2%). Functional independence (modified Rankin Scale 0-2) at 90 days was observed in 58.7%.</p><p>CONCLUSION: This study shows that first-line aspiration, especially in a quadriaxial approach, can be effective and safe. These findings should be evaluated in prospective trials.</p>}},
  author       = {{Aebischer, Vera and Brehm, Alex and Rommers, Nikki and Spiotta, Alejandro and Sowlat, Mohammad and Raghuram, Karthik and Cappuzzo, Justin M and Beecher, Jeffrey and Matouk, Charles and Amllay, Abdelaziz and Rohr, Axel and Heran, Manraj and Volders, David and Mosimann, Pascal J and Al-Tibi, Mohammad and Wassélius, Johan and Hansen, Björn M and Holtmannspötter, Markus and Schlösser, Martin and Meckel, Stephan and Aoua, Oumaima and Giragani, Suresh and Boghi, Andrea and Ntoulias, Nikolaos and Schulze-Zachau, Victor and Tsogkas, Ioannis and Blackham, Kristine A and Anastasiou, Aikaterini and Psychogios, Marios}},
  issn         = {{1869-1439}},
  language     = {{eng}},
  month        = {{09}},
  publisher    = {{Springer Science and Business Media B.V.}},
  series       = {{Clinical Neuroradiology}},
  title        = {{First-line Aspiration Thrombectomy with the RED43 Catheter for Acute Ischemic Stroke due to Medium or Distal Vessel Occlusion}},
  url          = {{http://dx.doi.org/10.1007/s00062-025-01567-8}},
  doi          = {{10.1007/s00062-025-01567-8}},
  year         = {{2025}},
}