Blodbildning. : Biologisk massproduktion under noggrann kontroll av cytokiner
(1995) In Lakartidningen 92(14). p.6-1475- Abstract
Haematopoiesis is regulated by unrelated, pleiotropic, and diverse regulatory molecules, cytokines, whose membrane receptors are related and restricted to a few families manifesting sequence homology. Most members of the cytokine receptor family which lack tyrosine kinase activity are composed of multiple chains. An accessory signal transducer can be shared by members of the receptor family. Cytokine receptor oligomerisation is required for signal transduction, which includes phosphorylation of receptors and cytoplasmic proteins. Upon ligand binding, the receptors for erythropoietin and G-CSF form homodimers, whereas other members of the receptor family form hetero-oligomers in order to generate high-affinity receptor and signal... (More)
Haematopoiesis is regulated by unrelated, pleiotropic, and diverse regulatory molecules, cytokines, whose membrane receptors are related and restricted to a few families manifesting sequence homology. Most members of the cytokine receptor family which lack tyrosine kinase activity are composed of multiple chains. An accessory signal transducer can be shared by members of the receptor family. Cytokine receptor oligomerisation is required for signal transduction, which includes phosphorylation of receptors and cytoplasmic proteins. Upon ligand binding, the receptors for erythropoietin and G-CSF form homodimers, whereas other members of the receptor family form hetero-oligomers in order to generate high-affinity receptor and signal transduction. In their cytoplasmic part, cytokine receptors contain distinct functional domains, proximal and distal to the membrane, that generate separate signals. Cytokines can be used to minimise chemotherapy-induced neutropenia and treat chronic neutropenia, and to shorten the period of aplasia following bone marrow transplantation.
(Less)- Abstract (Swedish)
- Blodbildning är en biologisk massproduktion som styrs av cytokiner. Dessa utgör en mångfald av peptidkedjor, som tjänar som överlevnads-, tillväxt- och utmognadsfaktorer och som dessutom stimulerar funktionellt aktiva blodceller. Cytokiner används t ex för att mina cytostatikainducerad neutropeni, för att avkorta aplasiperioden efter benmärgstransplantation och för att behandla kroniska neutropenier.
- author
- Olsson, Inge LU ; Bergh, Gösta LU ; Ehinger, Mats LU and Gullberg, Urban LU
- organization
- alternative title
- Hematopoiesis. Biological mass production closely regulated by cytokines
- publishing date
- 1995-04-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cytokines/genetics, Hematopoiesis, Hematopoietic Cell Growth Factors/genetics, Humans, Receptors, Colony-Stimulating Factor/genetics, Receptors, Cytokine/genetics, Signal Transduction
- in
- Lakartidningen
- volume
- 92
- issue
- 14
- pages
- 5 pages
- publisher
- Swedish Medical Association
- external identifiers
-
- scopus:0029636369
- pmid:7707797
- ISSN
- 0023-7205
- language
- Swedish
- LU publication?
- yes
- id
- 6c8c5f59-f0bb-4895-82da-33e29d746136
- date added to LUP
- 2022-01-23 15:39:09
- date last changed
- 2024-01-06 00:19:20
@article{6c8c5f59-f0bb-4895-82da-33e29d746136,
abstract = {{<p>Haematopoiesis is regulated by unrelated, pleiotropic, and diverse regulatory molecules, cytokines, whose membrane receptors are related and restricted to a few families manifesting sequence homology. Most members of the cytokine receptor family which lack tyrosine kinase activity are composed of multiple chains. An accessory signal transducer can be shared by members of the receptor family. Cytokine receptor oligomerisation is required for signal transduction, which includes phosphorylation of receptors and cytoplasmic proteins. Upon ligand binding, the receptors for erythropoietin and G-CSF form homodimers, whereas other members of the receptor family form hetero-oligomers in order to generate high-affinity receptor and signal transduction. In their cytoplasmic part, cytokine receptors contain distinct functional domains, proximal and distal to the membrane, that generate separate signals. Cytokines can be used to minimise chemotherapy-induced neutropenia and treat chronic neutropenia, and to shorten the period of aplasia following bone marrow transplantation.</p>}},
author = {{Olsson, Inge and Bergh, Gösta and Ehinger, Mats and Gullberg, Urban}},
issn = {{0023-7205}},
keywords = {{Cytokines/genetics; Hematopoiesis; Hematopoietic Cell Growth Factors/genetics; Humans; Receptors, Colony-Stimulating Factor/genetics; Receptors, Cytokine/genetics; Signal Transduction}},
language = {{swe}},
month = {{04}},
number = {{14}},
pages = {{6--1475}},
publisher = {{Swedish Medical Association}},
series = {{Lakartidningen}},
title = {{Blodbildning. : Biologisk massproduktion under noggrann kontroll av cytokiner}},
volume = {{92}},
year = {{1995}},
}