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Association between cerebrospinal fluid and plasma neurodegeneration biomarkers with brain atrophy in Alzheimer's disease

Pereira, Joana B.; Westman, Eric; Hansson, Oskar LU and , (2017) In Neurobiology of Aging 58. p.14-29
Abstract

The aggregation and deposition of amyloid-β (Aβ) peptides into plaques is an early event in Alzheimer's disease (AD), which is followed by different aspects of neurodegeneration that can be measured in the cerebrospinal fluid (CSF) or plasma using neurofilament light (NFL), neurogranin (Ng), total Tau (T-Tau), and phosphorylated tau (P-Tau) levels. The relationship between these biomarkers and regional brain atrophy across the different stages of AD remains largely unexplored. In this study, we assessed whether NFL, Ng, T-Tau, and P-Tau levels in CSF and NFL in plasma are associated with cortical thinning and subcortical volume loss in cognitively normal, mild cognitive impairment, and AD subjects with and without Aβ pathology. Our main... (More)

The aggregation and deposition of amyloid-β (Aβ) peptides into plaques is an early event in Alzheimer's disease (AD), which is followed by different aspects of neurodegeneration that can be measured in the cerebrospinal fluid (CSF) or plasma using neurofilament light (NFL), neurogranin (Ng), total Tau (T-Tau), and phosphorylated tau (P-Tau) levels. The relationship between these biomarkers and regional brain atrophy across the different stages of AD remains largely unexplored. In this study, we assessed whether NFL, Ng, T-Tau, and P-Tau levels in CSF and NFL in plasma are associated with cortical thinning and subcortical volume loss in cognitively normal, mild cognitive impairment, and AD subjects with and without Aβ pathology. Our main findings showed that CSF NFL levels were associated with brain atrophy in all groups, but plasma NFL only correlated with atrophy in symptomatic cases. In contrast, Ng was associated with regional brain atrophy only in individuals with Aβ pathology. Altogether, our main findings suggest that Ng is strongly associated with Aβ pathology, whereas NFL is more unspecific.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cortical thickness, Neurofilament light, Neurogranin, Subcortical volumes, Tau
in
Neurobiology of Aging
volume
58
pages
14 - 29
publisher
Elsevier
external identifiers
  • scopus:85021781610
ISSN
0197-4580
DOI
10.1016/j.neurobiolaging.2017.06.002
language
English
LU publication?
yes
id
6c906fea-5844-4a08-a4e3-a9721b13e715
date added to LUP
2017-07-28 14:47:30
date last changed
2017-08-07 15:06:53
@article{6c906fea-5844-4a08-a4e3-a9721b13e715,
  abstract     = {<p>The aggregation and deposition of amyloid-β (Aβ) peptides into plaques is an early event in Alzheimer's disease (AD), which is followed by different aspects of neurodegeneration that can be measured in the cerebrospinal fluid (CSF) or plasma using neurofilament light (NFL), neurogranin (Ng), total Tau (T-Tau), and phosphorylated tau (P-Tau) levels. The relationship between these biomarkers and regional brain atrophy across the different stages of AD remains largely unexplored. In this study, we assessed whether NFL, Ng, T-Tau, and P-Tau levels in CSF and NFL in plasma are associated with cortical thinning and subcortical volume loss in cognitively normal, mild cognitive impairment, and AD subjects with and without Aβ pathology. Our main findings showed that CSF NFL levels were associated with brain atrophy in all groups, but plasma NFL only correlated with atrophy in symptomatic cases. In contrast, Ng was associated with regional brain atrophy only in individuals with Aβ pathology. Altogether, our main findings suggest that Ng is strongly associated with Aβ pathology, whereas NFL is more unspecific.</p>},
  author       = {Pereira, Joana B. and Westman, Eric and Hansson, Oskar and , },
  issn         = {0197-4580},
  keyword      = {Cortical thickness,Neurofilament light,Neurogranin,Subcortical volumes,Tau},
  language     = {eng},
  month        = {10},
  pages        = {14--29},
  publisher    = {Elsevier},
  series       = {Neurobiology of Aging},
  title        = {Association between cerebrospinal fluid and plasma neurodegeneration biomarkers with brain atrophy in Alzheimer's disease},
  url          = {http://dx.doi.org/10.1016/j.neurobiolaging.2017.06.002},
  volume       = {58},
  year         = {2017},
}