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Development of a method for evaluation of absorbed doses in preclinical in vivo μcT

Deyhle, Richard T. LU ; Bernhardsson, Christian LU orcid ; Olsson, Lars E. LU orcid and Sydoff, Marie LU (2025) In Radiation Protection Dosimetry 201(13-14). p.868-876
Abstract

In vivo preclinical X-ray micro-computed tomography (μCT) imaging is widely used to obtain three-dimensional anatomical information of small animals. However, the potential for radiation exposure to influence experimental outcomes necessitates accurate dose estimation. The aim of this study was to develop a robust and reproducible method for estimating and evaluating absorbed doses in small animals undergoing preclinical in vivo μCT imaging. Absorbed doses were measured at four separate positions within a dedicated polymethyl methacrylate phantom using MCP-N (LiF, Cu, P) thermoluminescence dosemeters (TLDs) and a novel type of optically stimulated luminescence dosemeter (OSLD) made from household salt (NaCl). The findings were... (More)

In vivo preclinical X-ray micro-computed tomography (μCT) imaging is widely used to obtain three-dimensional anatomical information of small animals. However, the potential for radiation exposure to influence experimental outcomes necessitates accurate dose estimation. The aim of this study was to develop a robust and reproducible method for estimating and evaluating absorbed doses in small animals undergoing preclinical in vivo μCT imaging. Absorbed doses were measured at four separate positions within a dedicated polymethyl methacrylate phantom using MCP-N (LiF, Cu, P) thermoluminescence dosemeters (TLDs) and a novel type of optically stimulated luminescence dosemeter (OSLD) made from household salt (NaCl). The findings were benchmarked against the vendor's absorbed dose estimates, revealing a discrepancy between the measured and provided values. The results for the OSLDs followed a similar trend to the TLDs, though significant statistical differences were found between the luminescent dosemeters and the vendor values. In this study, a method for measuring the absorbed doses from μCT systems was presented. The results indicate a need for thorough dose measurements prior to performing longitudinal imaging studies.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Radiation Protection Dosimetry
volume
201
issue
13-14
pages
9 pages
publisher
Oxford University Press
external identifiers
  • scopus:105014611089
  • pmid:40875276
ISSN
0144-8420
DOI
10.1093/rpd/ncaf023
language
English
LU publication?
yes
id
6ca22929-4cd1-4295-bde3-df397f5cbe21
date added to LUP
2025-10-16 13:11:52
date last changed
2025-11-13 15:14:00
@article{6ca22929-4cd1-4295-bde3-df397f5cbe21,
  abstract     = {{<p>In vivo preclinical X-ray micro-computed tomography (μCT) imaging is widely used to obtain three-dimensional anatomical information of small animals. However, the potential for radiation exposure to influence experimental outcomes necessitates accurate dose estimation. The aim of this study was to develop a robust and reproducible method for estimating and evaluating absorbed doses in small animals undergoing preclinical in vivo μCT imaging. Absorbed doses were measured at four separate positions within a dedicated polymethyl methacrylate phantom using MCP-N (LiF, Cu, P) thermoluminescence dosemeters (TLDs) and a novel type of optically stimulated luminescence dosemeter (OSLD) made from household salt (NaCl). The findings were benchmarked against the vendor's absorbed dose estimates, revealing a discrepancy between the measured and provided values. The results for the OSLDs followed a similar trend to the TLDs, though significant statistical differences were found between the luminescent dosemeters and the vendor values. In this study, a method for measuring the absorbed doses from μCT systems was presented. The results indicate a need for thorough dose measurements prior to performing longitudinal imaging studies.</p>}},
  author       = {{Deyhle, Richard T. and Bernhardsson, Christian and Olsson, Lars E. and Sydoff, Marie}},
  issn         = {{0144-8420}},
  language     = {{eng}},
  number       = {{13-14}},
  pages        = {{868--876}},
  publisher    = {{Oxford University Press}},
  series       = {{Radiation Protection Dosimetry}},
  title        = {{Development of a method for evaluation of absorbed doses in preclinical in vivo μcT}},
  url          = {{http://dx.doi.org/10.1093/rpd/ncaf023}},
  doi          = {{10.1093/rpd/ncaf023}},
  volume       = {{201}},
  year         = {{2025}},
}