Dynamic (99m)Tc-MAG3 renography: images for quality control obtained by combining pharmacokinetic modelling, an anthropomorphic computer phantom and Monte Carlo simulated scintillation camera imaging.
(2013) In Physics in Medicine and Biology 58(10). p.3145-3161- Abstract
- In dynamic renal scintigraphy, the main interest is the radiopharmaceutical redistribution as a function of time. Quality control (QC) of renal procedures often relies on phantom experiments to compare image-based results with the measurement setup. A phantom with a realistic anatomy and time-varying activity distribution is therefore desirable. This work describes a pharmacokinetic (PK) compartment model for (99m)Tc-MAG3, used for defining a dynamic whole-body activity distribution within a digital phantom (XCAT) for accurate Monte Carlo (MC)-based images for QC. Each phantom structure is assigned a time-activity curve provided by the PK model, employing parameter values consistent with MAG3 pharmacokinetics. This approach ensures that... (More)
- In dynamic renal scintigraphy, the main interest is the radiopharmaceutical redistribution as a function of time. Quality control (QC) of renal procedures often relies on phantom experiments to compare image-based results with the measurement setup. A phantom with a realistic anatomy and time-varying activity distribution is therefore desirable. This work describes a pharmacokinetic (PK) compartment model for (99m)Tc-MAG3, used for defining a dynamic whole-body activity distribution within a digital phantom (XCAT) for accurate Monte Carlo (MC)-based images for QC. Each phantom structure is assigned a time-activity curve provided by the PK model, employing parameter values consistent with MAG3 pharmacokinetics. This approach ensures that the total amount of tracer in the phantom is preserved between time points, and it allows for modifications of the pharmacokinetics in a controlled fashion. By adjusting parameter values in the PK model, different clinically realistic scenarios can be mimicked, regarding, e.g., the relative renal uptake and renal transit time. Using the MC code SIMIND, a complete set of renography images including effects of photon attenuation, scattering, limited spatial resolution and noise, are simulated. The obtained image data can be used to evaluate quantitative techniques and computer software in clinical renography. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3733531
- author
- Brolin, Gustav LU ; Sjögreen Gleisner, Katarina LU and Ljungberg, Michael LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physics in Medicine and Biology
- volume
- 58
- issue
- 10
- pages
- 3145 - 3161
- publisher
- IOP Publishing
- external identifiers
-
- wos:000318273800005
- pmid:23603770
- scopus:84877617134
- pmid:23603770
- ISSN
- 1361-6560
- DOI
- 10.1088/0031-9155/58/10/3145
- language
- English
- LU publication?
- yes
- id
- 6ca2f9e4-db07-426e-b07d-9e1955d687e4 (old id 3733531)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23603770?dopt=Abstract
- date added to LUP
- 2016-04-01 10:38:31
- date last changed
- 2022-04-28 00:00:00
@article{6ca2f9e4-db07-426e-b07d-9e1955d687e4,
abstract = {{In dynamic renal scintigraphy, the main interest is the radiopharmaceutical redistribution as a function of time. Quality control (QC) of renal procedures often relies on phantom experiments to compare image-based results with the measurement setup. A phantom with a realistic anatomy and time-varying activity distribution is therefore desirable. This work describes a pharmacokinetic (PK) compartment model for (99m)Tc-MAG3, used for defining a dynamic whole-body activity distribution within a digital phantom (XCAT) for accurate Monte Carlo (MC)-based images for QC. Each phantom structure is assigned a time-activity curve provided by the PK model, employing parameter values consistent with MAG3 pharmacokinetics. This approach ensures that the total amount of tracer in the phantom is preserved between time points, and it allows for modifications of the pharmacokinetics in a controlled fashion. By adjusting parameter values in the PK model, different clinically realistic scenarios can be mimicked, regarding, e.g., the relative renal uptake and renal transit time. Using the MC code SIMIND, a complete set of renography images including effects of photon attenuation, scattering, limited spatial resolution and noise, are simulated. The obtained image data can be used to evaluate quantitative techniques and computer software in clinical renography.}},
author = {{Brolin, Gustav and Sjögreen Gleisner, Katarina and Ljungberg, Michael}},
issn = {{1361-6560}},
language = {{eng}},
number = {{10}},
pages = {{3145--3161}},
publisher = {{IOP Publishing}},
series = {{Physics in Medicine and Biology}},
title = {{Dynamic (99m)Tc-MAG3 renography: images for quality control obtained by combining pharmacokinetic modelling, an anthropomorphic computer phantom and Monte Carlo simulated scintillation camera imaging.}},
url = {{http://dx.doi.org/10.1088/0031-9155/58/10/3145}},
doi = {{10.1088/0031-9155/58/10/3145}},
volume = {{58}},
year = {{2013}},
}