Human metabolism of orally administered radioactive cobalt chloride.
(2015) In Journal of Environmental Radioactivity 143. p.152-158- Abstract
- This study investigated the human gastrointestinal uptake (f1) and subsequent whole-body retention of orally administered inorganic radioactive cobalt. Of eight adult volunteers aged between 24 and 68 years, seven were given solutions of (57)Co (T1/2 = 272 d) containing a stable cobalt carrier, and six were given carrier-free (58)Co (T1/2 = 71 d). The administered activities ranged between 25 and 103 kBq. The observed mean f1, based on 6 days accumulated urinary excretion sampling and whole-body counting, was 0.028 ± 0.0048 for carrier-free (58)Co, and 0.016 ± 0.0021 for carrier-associated (57)Co. These values were in reasonable agreement with values reported from previous studies involving a single intake of inorganic cobalt. The time... (More)
- This study investigated the human gastrointestinal uptake (f1) and subsequent whole-body retention of orally administered inorganic radioactive cobalt. Of eight adult volunteers aged between 24 and 68 years, seven were given solutions of (57)Co (T1/2 = 272 d) containing a stable cobalt carrier, and six were given carrier-free (58)Co (T1/2 = 71 d). The administered activities ranged between 25 and 103 kBq. The observed mean f1, based on 6 days accumulated urinary excretion sampling and whole-body counting, was 0.028 ± 0.0048 for carrier-free (58)Co, and 0.016 ± 0.0021 for carrier-associated (57)Co. These values were in reasonable agreement with values reported from previous studies involving a single intake of inorganic cobalt. The time pattern of the total retention (including residual cobalt in the GI tract) included a short-term component with a biological half-time of 0.71 ± 0.03 d (average ± 1 standard error of the mean for the two nuclides), an intermediate component with a mean half-time of 32 ± 8.5 d, and a long-term component (observed in two volunteers) with half-times ranging from 80 to 720 d for the two isotopes. From the present data we conclude that for the short-lived (57)Co and (58)Co, more than 95% of the internal absorbed dose was delivered within 7 days following oral intake, with a high individual variation influenced by the transit time of the unabsorbed cobalt through the gastro-intestinal tract. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5258035
- author
- Holstein, Hanna LU ; Ranebo, Ylva LU and Rääf, Christopher LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Environmental Radioactivity
- volume
- 143
- pages
- 152 - 158
- publisher
- Elsevier
- external identifiers
-
- pmid:25791772
- wos:000353096600020
- scopus:84924911250
- pmid:25791772
- ISSN
- 1879-1700
- DOI
- 10.1016/j.jenvrad.2015.02.006
- language
- English
- LU publication?
- yes
- id
- 6cb801c7-2f66-4af2-a4ec-237516cebd92 (old id 5258035)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25791772?dopt=Abstract
- date added to LUP
- 2016-04-01 10:16:43
- date last changed
- 2022-01-25 21:39:25
@article{6cb801c7-2f66-4af2-a4ec-237516cebd92,
abstract = {{This study investigated the human gastrointestinal uptake (f1) and subsequent whole-body retention of orally administered inorganic radioactive cobalt. Of eight adult volunteers aged between 24 and 68 years, seven were given solutions of (57)Co (T1/2 = 272 d) containing a stable cobalt carrier, and six were given carrier-free (58)Co (T1/2 = 71 d). The administered activities ranged between 25 and 103 kBq. The observed mean f1, based on 6 days accumulated urinary excretion sampling and whole-body counting, was 0.028 ± 0.0048 for carrier-free (58)Co, and 0.016 ± 0.0021 for carrier-associated (57)Co. These values were in reasonable agreement with values reported from previous studies involving a single intake of inorganic cobalt. The time pattern of the total retention (including residual cobalt in the GI tract) included a short-term component with a biological half-time of 0.71 ± 0.03 d (average ± 1 standard error of the mean for the two nuclides), an intermediate component with a mean half-time of 32 ± 8.5 d, and a long-term component (observed in two volunteers) with half-times ranging from 80 to 720 d for the two isotopes. From the present data we conclude that for the short-lived (57)Co and (58)Co, more than 95% of the internal absorbed dose was delivered within 7 days following oral intake, with a high individual variation influenced by the transit time of the unabsorbed cobalt through the gastro-intestinal tract.}},
author = {{Holstein, Hanna and Ranebo, Ylva and Rääf, Christopher}},
issn = {{1879-1700}},
language = {{eng}},
pages = {{152--158}},
publisher = {{Elsevier}},
series = {{Journal of Environmental Radioactivity}},
title = {{Human metabolism of orally administered radioactive cobalt chloride.}},
url = {{http://dx.doi.org/10.1016/j.jenvrad.2015.02.006}},
doi = {{10.1016/j.jenvrad.2015.02.006}},
volume = {{143}},
year = {{2015}},
}