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The Effect of Cynara scolymus on Blood Pressure and BMI in Hypertensive Patients : A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial

Ardalani, Hamidreza LU ; Jandaghi, Parisa ; Meraji, Aramsadat and Hassanpour Moghadam, Maryam (2020) In Complementary Medicine Research 27(1). p.40-46
Abstract

BACKGROUND: Recent studies have suggested that artichoke (Cynara scolymus L.) may reduce certain biochemical blood factors but the efficacy of this plant on blood pressure (BP) has not yet been investigated. In this study, we determined the clinical efficacy of C. scolymus on BP and body mass index (BMI) in hypertensive patients as an adjunctive to captopril for the first time.

METHODS: The total phenolic content and gas chromatography-mass spectrometry metabolite profiling in leaves of C. scolymus have been evaluated. A clinical trial was subsequently carried out on 40 patients to determine the effect of C. scolymus on BP and BMI in hypertensive patients. The treatment group received capsules... (More)

BACKGROUND: Recent studies have suggested that artichoke (Cynara scolymus L.) may reduce certain biochemical blood factors but the efficacy of this plant on blood pressure (BP) has not yet been investigated. In this study, we determined the clinical efficacy of C. scolymus on BP and body mass index (BMI) in hypertensive patients as an adjunctive to captopril for the first time.

METHODS: The total phenolic content and gas chromatography-mass spectrometry metabolite profiling in leaves of C. scolymus have been evaluated. A clinical trial was subsequently carried out on 40 patients to determine the effect of C. scolymus on BP and BMI in hypertensive patients. The treatment group received capsules containing C. scolymus(500 mg twice daily) and the placebo group received starch powder for 8 weeks. Systolic blood pressure (SBP), diastolic blood pressure, and BMI were determined before and after the study.

RESULTS: A significant improvement of the BMI was seen in the C. scolymus group compared with the placebo group (p = 0.04).

CONCLUSIONS: Our findings demonstrated that the consumption of C. scolymus powder as a rich source of phenolic and antioxidant compounds could potentially improve BMI and SBP in hypertensive patients. Therefore, more trials are needed to confirm or reject the antihypertensive impact of artichoke.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Administration, Oral, Adult, Aged, Blood Pressure/drug effects, Body Mass Index, Capsules, Captopril/therapeutic use, Cynara scolymus/chemistry, Double-Blind Method, Female, Gas Chromatography-Mass Spectrometry, Humans, Hypertension/drug therapy, Male, Middle Aged, Plant Extracts/therapeutic use, Plant Leaves/chemistry
in
Complementary Medicine Research
volume
27
issue
1
pages
7 pages
publisher
Karger
external identifiers
  • scopus:85072118224
  • pmid:31484191
ISSN
2504-2092
DOI
10.1159/000502280
language
English
LU publication?
no
id
6cc608c5-c959-41ba-a2f2-42d4c2ff0d65
date added to LUP
2021-06-01 20:58:56
date last changed
2024-04-06 04:26:39
@article{6cc608c5-c959-41ba-a2f2-42d4c2ff0d65,
  abstract     = {{<p>BACKGROUND: Recent studies have suggested that artichoke (<i>Cynara scolymus</i> L.) may reduce certain biochemical blood factors but the efficacy of this plant on blood pressure (BP) has not yet been investigated. In this study, we determined the clinical efficacy of <i>C. scolymus </i>on BP and body mass index (BMI) in hypertensive patients as an adjunctive to captopril for the first time.</p><p>METHODS: The total phenolic content and gas chromatography-mass spectrometry metabolite profiling in leaves of <i>C. scolymus</i> have been evaluated. A clinical trial was subsequently carried out on 40 patients to determine the effect of <i>C. scolymus</i> on BP and BMI in hypertensive patients. The treatment group received capsules containing <i>C. scolymus</i>(500 mg twice daily) and the placebo group received starch powder for 8 weeks. Systolic blood pressure (SBP), diastolic blood pressure, and BMI were determined before and after the study.</p><p>RESULTS: A significant improvement of the BMI was seen in the <i>C. scolymus</i> group compared with the placebo group (p = 0.04).</p><p>CONCLUSIONS: Our findings demonstrated that the consumption of <i>C. scolymus</i> powder as a rich source of phenolic and antioxidant compounds could potentially improve BMI and SBP in hypertensive patients. Therefore, more trials are needed to confirm or reject the antihypertensive impact of artichoke.</p>}},
  author       = {{Ardalani, Hamidreza and Jandaghi, Parisa and Meraji, Aramsadat and Hassanpour Moghadam, Maryam}},
  issn         = {{2504-2092}},
  keywords     = {{Administration, Oral; Adult; Aged; Blood Pressure/drug effects; Body Mass Index; Capsules; Captopril/therapeutic use; Cynara scolymus/chemistry; Double-Blind Method; Female; Gas Chromatography-Mass Spectrometry; Humans; Hypertension/drug therapy; Male; Middle Aged; Plant Extracts/therapeutic use; Plant Leaves/chemistry}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{1}},
  pages        = {{40--46}},
  publisher    = {{Karger}},
  series       = {{Complementary Medicine Research}},
  title        = {{The Effect of <i>Cynara scolymus</i> on Blood Pressure and BMI in Hypertensive Patients : A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial}},
  url          = {{http://dx.doi.org/10.1159/000502280}},
  doi          = {{10.1159/000502280}},
  volume       = {{27}},
  year         = {{2020}},
}