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Significance and translational value of high-frequency cortico-basal ganglia oscillations in Parkinson's disease

Petersson, Per LU ; Halje, Pär LU and Cenci, M. Angela LU (2019) In Journal of Parkinson's Disease 9(1). p.183-196
Abstract

The mechanisms and significance of basal ganglia oscillations is a fundamental research question engaging both clinical and basic investigators. In Parkinson's disease (PD), neural activity in basal ganglia nuclei is characterized by oscillatory patterns that are believed to disrupt the dynamic processing of movement-related information and thus generate motor symptoms. Beta-band oscillations associated with hypokinetic states have been reviewed in several excellent previous articles. Here we focus on faster oscillatory phenomena that have been reported in association with a diverse range of motor states. We review the occurrence of different types of fast oscillations and the evidence supporting their pathophysiological role. We also... (More)

The mechanisms and significance of basal ganglia oscillations is a fundamental research question engaging both clinical and basic investigators. In Parkinson's disease (PD), neural activity in basal ganglia nuclei is characterized by oscillatory patterns that are believed to disrupt the dynamic processing of movement-related information and thus generate motor symptoms. Beta-band oscillations associated with hypokinetic states have been reviewed in several excellent previous articles. Here we focus on faster oscillatory phenomena that have been reported in association with a diverse range of motor states. We review the occurrence of different types of fast oscillations and the evidence supporting their pathophysiological role. We also provide a general discussion on the definition, possible mechanisms, and translational value of synchronized oscillations of different frequencies in cortico-basal ganglia structures. Revealing how oscillatory phenomena are caused and spread in cortico-basal ganglia-thalamocortical networks will offer a key to unlock the neural codes of both motor and non-motor symptoms in PD. In preclinical therapeutic research, recording of oscillatory neural activities holds the promise to unravel mechanisms of action of current and future treatments.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
animal models, bradykinesia, cortex, dyskinesia, movement disorders, Pathophysiology, thalamus
in
Journal of Parkinson's Disease
volume
9
issue
1
pages
14 pages
publisher
IOS Press
external identifiers
  • scopus:85061211651
ISSN
1877-7171
DOI
10.3233/JPD-181480
language
English
LU publication?
yes
id
6cd2521d-f02f-4144-a69d-d6988c68b240
date added to LUP
2019-02-20 10:56:19
date last changed
2019-03-12 04:22:20
@article{6cd2521d-f02f-4144-a69d-d6988c68b240,
  abstract     = {<p>The mechanisms and significance of basal ganglia oscillations is a fundamental research question engaging both clinical and basic investigators. In Parkinson's disease (PD), neural activity in basal ganglia nuclei is characterized by oscillatory patterns that are believed to disrupt the dynamic processing of movement-related information and thus generate motor symptoms. Beta-band oscillations associated with hypokinetic states have been reviewed in several excellent previous articles. Here we focus on faster oscillatory phenomena that have been reported in association with a diverse range of motor states. We review the occurrence of different types of fast oscillations and the evidence supporting their pathophysiological role. We also provide a general discussion on the definition, possible mechanisms, and translational value of synchronized oscillations of different frequencies in cortico-basal ganglia structures. Revealing how oscillatory phenomena are caused and spread in cortico-basal ganglia-thalamocortical networks will offer a key to unlock the neural codes of both motor and non-motor symptoms in PD. In preclinical therapeutic research, recording of oscillatory neural activities holds the promise to unravel mechanisms of action of current and future treatments.</p>},
  author       = {Petersson, Per and Halje, Pär and Cenci, M. Angela},
  issn         = {1877-7171},
  keyword      = {animal models,bradykinesia,cortex,dyskinesia,movement disorders,Pathophysiology,thalamus},
  language     = {eng},
  number       = {1},
  pages        = {183--196},
  publisher    = {IOS Press},
  series       = {Journal of Parkinson's Disease},
  title        = {Significance and translational value of high-frequency cortico-basal ganglia oscillations in Parkinson's disease},
  url          = {http://dx.doi.org/10.3233/JPD-181480},
  volume       = {9},
  year         = {2019},
}