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Discrete gene loci regulate neurodegeneration, lymphocyte infiltration, and major histocompatibility complex class II expression in the CNS

Lidman, Olle; Swanberg, Maria LU ; Horvath, Linn; Broman, Karl W.; Olsson, Tomas and Piehl, Fredrik (2003) In The Journal of neuroscience : the official journal of the Society for Neuroscience 23(30). p.23-9817
Abstract

Neurodegeneration and inflammation are fundamental aspects of many neurological diseases. A genome-wide scan of the response to ventral root avulsion (VRA) in a rat F2 cross discloses specific gene regions that regulate these processes. Two gene loci displayed linkage to neurodegeneration and T cell infiltration, respectively, and a single locus displayed extreme linkage to VRA-induced major histocompatibility complex class II expression on microglia. The demonstration that polymorphic genes in different loci control neurodegeneration and CNS inflammation has implications for various experimental rodent nervous system paradigms and potentially for genetically regulated susceptibility to a variety of human CNS diseases.

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Contribution to journal
publication status
published
keywords
Animals, Astrocytes, Axotomy, Central Nervous System, Crosses, Genetic, Disease Progression, Female, Genetic Linkage, Genotype, Histocompatibility Antigens Class II, Male, Microglia, Neurodegenerative Diseases, Neurons, Phenotype, Radiculopathy, Rats, Rats, Inbred Strains, Retrograde Degeneration, T-Lymphocytes, Journal Article, Research Support, Non-U.S. Gov't
in
The Journal of neuroscience : the official journal of the Society for Neuroscience
volume
23
issue
30
pages
7 pages
publisher
Society for Neuroscience
external identifiers
  • scopus:0242609171
ISSN
1529-2401
language
English
LU publication?
no
id
6cf2b2a7-fb92-4471-a581-d380a6114a48
date added to LUP
2017-02-22 09:54:30
date last changed
2017-08-06 05:18:09
@article{6cf2b2a7-fb92-4471-a581-d380a6114a48,
  abstract     = {<p>Neurodegeneration and inflammation are fundamental aspects of many neurological diseases. A genome-wide scan of the response to ventral root avulsion (VRA) in a rat F2 cross discloses specific gene regions that regulate these processes. Two gene loci displayed linkage to neurodegeneration and T cell infiltration, respectively, and a single locus displayed extreme linkage to VRA-induced major histocompatibility complex class II expression on microglia. The demonstration that polymorphic genes in different loci control neurodegeneration and CNS inflammation has implications for various experimental rodent nervous system paradigms and potentially for genetically regulated susceptibility to a variety of human CNS diseases.</p>},
  author       = {Lidman, Olle and Swanberg, Maria and Horvath, Linn and Broman, Karl W. and Olsson, Tomas and Piehl, Fredrik},
  issn         = {1529-2401},
  keyword      = {Animals,Astrocytes,Axotomy,Central Nervous System,Crosses, Genetic,Disease Progression,Female,Genetic Linkage,Genotype,Histocompatibility Antigens Class II,Male,Microglia,Neurodegenerative Diseases,Neurons,Phenotype,Radiculopathy,Rats,Rats, Inbred Strains,Retrograde Degeneration,T-Lymphocytes,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {30},
  pages        = {23--9817},
  publisher    = {Society for Neuroscience},
  series       = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  title        = {Discrete gene loci regulate neurodegeneration, lymphocyte infiltration, and major histocompatibility complex class II expression in the CNS},
  volume       = {23},
  year         = {2003},
}