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The interplay between host haemostatic systems and Leptospira spp. infections

Vieira, Monica L LU ; Herwald, Heiko LU and Nascimento, Ana Lucia T O (2020) In Critical reviews in microbiology 46(2). p.121-135
Abstract

Hemostasis is a defence mechanism that protects the integrity of the vascular system and is comprised of the coagulation cascade, fibrinolysis, platelet aggregation, and vascular endothelium. Besides the primary function in preserving the vascular integrity, the haemostatic system cooperates with immune and inflammatory processes to eliminate invading pathogens during microbial infections. Under pathological manifestations, hemostasis must therefore interact in a coordinated manner with inflammatory responses and immune reactions. Several pathogens can modulate these host-derived countermeasures by specifically targeting certain haemostatic components for their own benefit. Thus, the ability to modulate host defence systems has to be... (More)

Hemostasis is a defence mechanism that protects the integrity of the vascular system and is comprised of the coagulation cascade, fibrinolysis, platelet aggregation, and vascular endothelium. Besides the primary function in preserving the vascular integrity, the haemostatic system cooperates with immune and inflammatory processes to eliminate invading pathogens during microbial infections. Under pathological manifestations, hemostasis must therefore interact in a coordinated manner with inflammatory responses and immune reactions. Several pathogens can modulate these host-derived countermeasures by specifically targeting certain haemostatic components for their own benefit. Thus, the ability to modulate host defence systems has to be considered as an essential bacterial virulence mechanism. Complications that bacterial pathogens can induce are therefore often the consequence of evoked host responses. A comprehensive understanding of the molecular mechanisms triggered in infectious processes may help to develop prophylactic methods and novel therapies for the patients suffering from a particular infectious disease. This review aims to provide a critical updated compiling of recent studies on how the pathogenic Leptospira can interact with and manipulate the host haemostatic systems and the consequences for leptospirosis pathogenesis.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
coagulation, hemostasis, host–pathogen interactions, infectious diseases, Leptospirosis
in
Critical reviews in microbiology
volume
46
issue
2
pages
15 pages
publisher
Informa Healthcare
external identifiers
  • pmid:32141788
  • scopus:85081291372
ISSN
1040-841X
DOI
10.1080/1040841X.2020.1735299
language
English
LU publication?
yes
id
6cf96394-3329-47d0-9271-f84343efc829
date added to LUP
2020-03-12 07:45:23
date last changed
2021-02-17 07:47:42
@article{6cf96394-3329-47d0-9271-f84343efc829,
  abstract     = {<p>Hemostasis is a defence mechanism that protects the integrity of the vascular system and is comprised of the coagulation cascade, fibrinolysis, platelet aggregation, and vascular endothelium. Besides the primary function in preserving the vascular integrity, the haemostatic system cooperates with immune and inflammatory processes to eliminate invading pathogens during microbial infections. Under pathological manifestations, hemostasis must therefore interact in a coordinated manner with inflammatory responses and immune reactions. Several pathogens can modulate these host-derived countermeasures by specifically targeting certain haemostatic components for their own benefit. Thus, the ability to modulate host defence systems has to be considered as an essential bacterial virulence mechanism. Complications that bacterial pathogens can induce are therefore often the consequence of evoked host responses. A comprehensive understanding of the molecular mechanisms triggered in infectious processes may help to develop prophylactic methods and novel therapies for the patients suffering from a particular infectious disease. This review aims to provide a critical updated compiling of recent studies on how the pathogenic Leptospira can interact with and manipulate the host haemostatic systems and the consequences for leptospirosis pathogenesis.</p>},
  author       = {Vieira, Monica L and Herwald, Heiko and Nascimento, Ana Lucia T O},
  issn         = {1040-841X},
  language     = {eng},
  month        = {03},
  number       = {2},
  pages        = {121--135},
  publisher    = {Informa Healthcare},
  series       = {Critical reviews in microbiology},
  title        = {The interplay between host haemostatic systems and Leptospira spp. infections},
  url          = {http://dx.doi.org/10.1080/1040841X.2020.1735299},
  doi          = {10.1080/1040841X.2020.1735299},
  volume       = {46},
  year         = {2020},
}