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Acute myeloid leukemia

Johansson, Bertil LU and Harrison, Christine J. (2015) In Cancer Cytogenetics p.62-125
Abstract

Acute leukemia is a worldwide disease with an incidence of approximately 4/100 000 per year; 70% of the cases are acute myeloid leukemia (AML). The salient pathologic feature of AML is the excessive accumulation of immature myeloid blasts in the bone marrow (BM). This maturation arrest, a characteristic of acute leukemias, prevents normal hematopoiesis and leads, directly or indirectly, to a lack of differentiated granulocytes, monocytes, thrombocytes, and erythrocytes. Chromosome banding analyses reveal acquired, clonal chromosomal abnormalities in the majority of AML cases, with the frequencies and types of aberrations to some extent being influenced by factors such as age, previous treatment/genotoxic exposure, gender,... (More)

Acute leukemia is a worldwide disease with an incidence of approximately 4/100 000 per year; 70% of the cases are acute myeloid leukemia (AML). The salient pathologic feature of AML is the excessive accumulation of immature myeloid blasts in the bone marrow (BM). This maturation arrest, a characteristic of acute leukemias, prevents normal hematopoiesis and leads, directly or indirectly, to a lack of differentiated granulocytes, monocytes, thrombocytes, and erythrocytes. Chromosome banding analyses reveal acquired, clonal chromosomal abnormalities in the majority of AML cases, with the frequencies and types of aberrations to some extent being influenced by factors such as age, previous treatment/genotoxic exposure, gender, geographic/ethnic origin, and constitutional genetics. This chapter summarizes the cytogenetic, molecular genetic and clinical features of AML-associated numerical and structural abnormalities. It explains the characteristic karyotypic patterns in AML. Complex Karyotypic (CK), monosomal Karyotype (MK), normal Karyotype (NK) are the chromosomal abnormalities reported in AML.

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Chromosomal abnormalities, Chromosome banding analyses, Complex karyotypic, Cute myeloid leukemia, Monosomal karyotype, Normal karyotype
in
Cancer Cytogenetics
editor
Heim, Sverre; Mitelman, Felix; and
pages
64 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85015874743
ISBN
9781118795538
9781118795569
DOI
10.1002/9781118795569.ch6
language
English
LU publication?
yes
id
6d135e41-50cf-4cca-abef-0c03268c3686
date added to LUP
2017-04-20 11:28:53
date last changed
2017-09-24 05:09:55
@inbook{6d135e41-50cf-4cca-abef-0c03268c3686,
  abstract     = {<p>Acute leukemia is a worldwide disease with an incidence of approximately 4/100 000 per year; 70% of the cases are acute myeloid leukemia (AML). The salient pathologic feature of AML is the excessive accumulation of immature myeloid blasts in the bone marrow (BM). This maturation arrest, a characteristic of acute leukemias, prevents normal hematopoiesis and leads, directly or indirectly, to a lack of differentiated granulocytes, monocytes, thrombocytes, and erythrocytes. Chromosome banding analyses reveal acquired, clonal chromosomal abnormalities in the majority of AML cases, with the frequencies and types of aberrations to some extent being influenced by factors such as age, previous treatment/genotoxic exposure, gender, geographic/ethnic origin, and constitutional genetics. This chapter summarizes the cytogenetic, molecular genetic and clinical features of AML-associated numerical and structural abnormalities. It explains the characteristic karyotypic patterns in AML. Complex Karyotypic (CK), monosomal Karyotype (MK), normal Karyotype (NK) are the chromosomal abnormalities reported in AML.</p>},
  author       = {Johansson, Bertil and Harrison, Christine J.},
  editor       = {Heim, Sverre and Mitelman, Felix},
  isbn         = {9781118795538},
  keyword      = {Chromosomal abnormalities,Chromosome banding analyses,Complex karyotypic,Cute myeloid leukemia,Monosomal karyotype,Normal karyotype},
  language     = {eng},
  pages        = {62--125},
  publisher    = {Wiley-Blackwell},
  series       = {Cancer Cytogenetics},
  title        = {Acute myeloid leukemia},
  url          = {http://dx.doi.org/10.1002/9781118795569.ch6},
  year         = {2015},
}