Acute myeloid leukemia
(2015) p.62-125- Abstract
Acute leukemia is a worldwide disease with an incidence of approximately 4/100 000 per year; 70% of the cases are acute myeloid leukemia (AML). The salient pathologic feature of AML is the excessive accumulation of immature myeloid blasts in the bone marrow (BM). This maturation arrest, a characteristic of acute leukemias, prevents normal hematopoiesis and leads, directly or indirectly, to a lack of differentiated granulocytes, monocytes, thrombocytes, and erythrocytes. Chromosome banding analyses reveal acquired, clonal chromosomal abnormalities in the majority of AML cases, with the frequencies and types of aberrations to some extent being influenced by factors such as age, previous treatment/genotoxic exposure, gender,... (More)
Acute leukemia is a worldwide disease with an incidence of approximately 4/100 000 per year; 70% of the cases are acute myeloid leukemia (AML). The salient pathologic feature of AML is the excessive accumulation of immature myeloid blasts in the bone marrow (BM). This maturation arrest, a characteristic of acute leukemias, prevents normal hematopoiesis and leads, directly or indirectly, to a lack of differentiated granulocytes, monocytes, thrombocytes, and erythrocytes. Chromosome banding analyses reveal acquired, clonal chromosomal abnormalities in the majority of AML cases, with the frequencies and types of aberrations to some extent being influenced by factors such as age, previous treatment/genotoxic exposure, gender, geographic/ethnic origin, and constitutional genetics. This chapter summarizes the cytogenetic, molecular genetic and clinical features of AML-associated numerical and structural abnormalities. It explains the characteristic karyotypic patterns in AML. Complex Karyotypic (CK), monosomal Karyotype (MK), normal Karyotype (NK) are the chromosomal abnormalities reported in AML.
(Less)
- author
- Johansson, Bertil LU and Harrison, Christine J.
- organization
- publishing date
- 2015
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Chromosomal abnormalities, Chromosome banding analyses, Complex karyotypic, Cute myeloid leukemia, Monosomal karyotype, Normal karyotype
- host publication
- Cancer Cytogenetics : Chromosomal and Molecular Genetic Aberrations of Tumor Cells - Chromosomal and Molecular Genetic Aberrations of Tumor Cells
- editor
- Heim, Sverre and Mitelman, Felix
- edition
- 4th
- pages
- 64 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85015874743
- ISBN
- 9781118795538
- 9781118795569
- DOI
- 10.1002/9781118795569.ch6
- language
- English
- LU publication?
- yes
- id
- 6d135e41-50cf-4cca-abef-0c03268c3686
- date added to LUP
- 2017-04-20 11:28:53
- date last changed
- 2025-01-20 13:20:51
@inbook{6d135e41-50cf-4cca-abef-0c03268c3686,
abstract = {{<p>Acute leukemia is a worldwide disease with an incidence of approximately 4/100 000 per year; 70% of the cases are acute myeloid leukemia (AML). The salient pathologic feature of AML is the excessive accumulation of immature myeloid blasts in the bone marrow (BM). This maturation arrest, a characteristic of acute leukemias, prevents normal hematopoiesis and leads, directly or indirectly, to a lack of differentiated granulocytes, monocytes, thrombocytes, and erythrocytes. Chromosome banding analyses reveal acquired, clonal chromosomal abnormalities in the majority of AML cases, with the frequencies and types of aberrations to some extent being influenced by factors such as age, previous treatment/genotoxic exposure, gender, geographic/ethnic origin, and constitutional genetics. This chapter summarizes the cytogenetic, molecular genetic and clinical features of AML-associated numerical and structural abnormalities. It explains the characteristic karyotypic patterns in AML. Complex Karyotypic (CK), monosomal Karyotype (MK), normal Karyotype (NK) are the chromosomal abnormalities reported in AML.</p>}},
author = {{Johansson, Bertil and Harrison, Christine J.}},
booktitle = {{Cancer Cytogenetics : Chromosomal and Molecular Genetic Aberrations of Tumor Cells}},
editor = {{Heim, Sverre and Mitelman, Felix}},
isbn = {{9781118795538}},
keywords = {{Chromosomal abnormalities; Chromosome banding analyses; Complex karyotypic; Cute myeloid leukemia; Monosomal karyotype; Normal karyotype}},
language = {{eng}},
pages = {{62--125}},
publisher = {{Wiley-Blackwell}},
title = {{Acute myeloid leukemia}},
url = {{http://dx.doi.org/10.1002/9781118795569.ch6}},
doi = {{10.1002/9781118795569.ch6}},
year = {{2015}},
}