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Tropisetron (Navoban) in the prevention of chemotherapy-induced nausea and vomiting--the Nordic experience

Sorbe, B ; Andersson, H ; Schmidt, M ; Söderberg, M ; Högberg, T LU ; Wernstedt, L ; Janson, E T ; Ehrnström, B ; Kjaer, M and Havsteen, H , et al. (1994) In Supportive Care in Cancer 2(6). p.9-393
Abstract

An open, noncomparative, Nordic multicenter study was carried out during 1991-1992 to evaluate the 5-HT3 receptor antagonist tropisetron (Navoban) as an antiemetic agent for various types of cancer chemotherapy. A total of 630 patients were recruited from 15 centers in Sweden, Denmark, and Finland. Gynecological cancers (60%), breast cancer (15%), and lung cancer (10%) were the main diagnoses. Prior experience of chemotherapy was documented in 338 patients (54%). In 260 patients (41%), cisplatin was part of the cytostatic regimen. Carboplatin (23%), doxorubicin (27%), and epidoxorubicin (24%) were also frequently included. In all, 23 cytostatic agents were used in various combinations. The mean number of courses studied was 4.6 (range... (More)

An open, noncomparative, Nordic multicenter study was carried out during 1991-1992 to evaluate the 5-HT3 receptor antagonist tropisetron (Navoban) as an antiemetic agent for various types of cancer chemotherapy. A total of 630 patients were recruited from 15 centers in Sweden, Denmark, and Finland. Gynecological cancers (60%), breast cancer (15%), and lung cancer (10%) were the main diagnoses. Prior experience of chemotherapy was documented in 338 patients (54%). In 260 patients (41%), cisplatin was part of the cytostatic regimen. Carboplatin (23%), doxorubicin (27%), and epidoxorubicin (24%) were also frequently included. In all, 23 cytostatic agents were used in various combinations. The mean number of courses studied was 4.6 (range 1-19). Altogether, 394 of 619 evaluable patients (64%) were completely protected from acute nausea and vomiting during the first course of chemotherapy. Delayed nausea and vomiting were completely prevented in 45%-73% (days 2-6) in the complete series. Treatment efficacy remained stable (60%-79%) during ten consecutive courses of chemotherapy. With noncisplatin regimens, complete protection from acute nausea and vomiting was achieved in 72% compared with 52% for cisplatin regimens (P < 0.0001). Patients without prior experience of chemotherapy had higher control rates of acute nausea and vomiting (72%) compared to patients treated before (57%) during the first course, but not later on. There were no differences in delayed nausea and vomiting.(ABSTRACT TRUNCATED AT 250 WORDS)

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Adult, Aged, Aged, 80 and over, Antiemetics/adverse effects, Antineoplastic Combined Chemotherapy Protocols/adverse effects, Female, Finland, Humans, Indoles/adverse effects, Male, Middle Aged, Nausea/chemically induced, Neoplasms/drug therapy, Scandinavian and Nordic Countries, Sex Factors, Treatment Outcome, Tropisetron, Vomiting/chemically induced
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Supportive Care in Cancer
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2
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6
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7 pages
publisher
Springer
external identifiers
  • scopus:0028541803
  • pmid:7858934
ISSN
0941-4355
DOI
10.1007/BF00344055
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English
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6d15a4d7-4fa4-4c29-b803-e49844e6772f
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2019-09-20 08:08:55
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@article{6d15a4d7-4fa4-4c29-b803-e49844e6772f,
  abstract     = {<p>An open, noncomparative, Nordic multicenter study was carried out during 1991-1992 to evaluate the 5-HT3 receptor antagonist tropisetron (Navoban) as an antiemetic agent for various types of cancer chemotherapy. A total of 630 patients were recruited from 15 centers in Sweden, Denmark, and Finland. Gynecological cancers (60%), breast cancer (15%), and lung cancer (10%) were the main diagnoses. Prior experience of chemotherapy was documented in 338 patients (54%). In 260 patients (41%), cisplatin was part of the cytostatic regimen. Carboplatin (23%), doxorubicin (27%), and epidoxorubicin (24%) were also frequently included. In all, 23 cytostatic agents were used in various combinations. The mean number of courses studied was 4.6 (range 1-19). Altogether, 394 of 619 evaluable patients (64%) were completely protected from acute nausea and vomiting during the first course of chemotherapy. Delayed nausea and vomiting were completely prevented in 45%-73% (days 2-6) in the complete series. Treatment efficacy remained stable (60%-79%) during ten consecutive courses of chemotherapy. With noncisplatin regimens, complete protection from acute nausea and vomiting was achieved in 72% compared with 52% for cisplatin regimens (P &lt; 0.0001). Patients without prior experience of chemotherapy had higher control rates of acute nausea and vomiting (72%) compared to patients treated before (57%) during the first course, but not later on. There were no differences in delayed nausea and vomiting.(ABSTRACT TRUNCATED AT 250 WORDS)</p>},
  author       = {Sorbe, B and Andersson, H and Schmidt, M and Söderberg, M and Högberg, T and Wernstedt, L and Janson, E T and Ehrnström, B and Kjaer, M and Havsteen, H and Overgaard, M and Sandberg, Erik and Flander, M and Heikkinen, M and Nikkanen, V},
  issn         = {0941-4355},
  language     = {eng},
  number       = {6},
  pages        = {9--393},
  publisher    = {Springer},
  series       = {Supportive Care in Cancer},
  title        = {Tropisetron (Navoban) in the prevention of chemotherapy-induced nausea and vomiting--the Nordic experience},
  url          = {http://dx.doi.org/10.1007/BF00344055},
  doi          = {10.1007/BF00344055},
  volume       = {2},
  year         = {1994},
}