Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors
Wang, B ; Sun, J S ; Kitamoto, S ; Yang, M ; Grubb, Anders LU
; Chapman, H A
; Kalluri, R
and Shi, G P
(2006)
In Journal of Biological Chemistry
281(9).
p.6020-6029
- Abstract
- The cysteine protease cathepsin S is highly expressed in malignant tissues. By using a mouse model of multistage murine pancreatic islet cell carcinogenesis in which cysteine cathepsin activity has been functionally implicated, we demonstrated that selective cathepsin S deficiency impaired angiogenesis and tumor cell proliferation, thereby impairing angiogenic islet formation and the growth of solid tumors, whereas the absence of its endogenous inhibitor cystatin C resulted in opposite phenotypes. Although mitogenic vascular endothelial growth factor, transforming growth factor-beta 1, and the anti-angiogenic endostatin levels in either serum or carcinoma tissue extracts did not change in cathepsin S- or cystatin C-null mice, tumor tissue... (More)
- The cysteine protease cathepsin S is highly expressed in malignant tissues. By using a mouse model of multistage murine pancreatic islet cell carcinogenesis in which cysteine cathepsin activity has been functionally implicated, we demonstrated that selective cathepsin S deficiency impaired angiogenesis and tumor cell proliferation, thereby impairing angiogenic islet formation and the growth of solid tumors, whereas the absence of its endogenous inhibitor cystatin C resulted in opposite phenotypes. Although mitogenic vascular endothelial growth factor, transforming growth factor-beta 1, and the anti-angiogenic endostatin levels in either serum or carcinoma tissue extracts did not change in cathepsin S- or cystatin C-null mice, tumor tissue basic fibroblast growth factor and serum type 1 insulin growth factor levels were higher in cystatin C-null mice, and serum type 1 insulin growth factor levels were also increased in cathepsin S-null mice. Furthermore, cathepsin S affected the production of type IV collagen-derived anti-angiogenic peptides and the generation of bioactive pro-angiogenic gamma 2 fragments from laminin-5, revealing a functional role for cathepsin S in angiogenesis and neoplastic progression. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/417130
- author
- Wang, B
; Sun, J S
; Kitamoto, S
; Yang, M
; Grubb, Anders
LU
; Chapman, H A
; Kalluri, R
and Shi, G P
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Biological Chemistry
- volume
- 281
- issue
- 9
- pages
- 6020 - 6029
- publisher
- American Society for Biochemistry and Molecular Biology
- external identifiers
-
- wos:000235568900083
- pmid:16365041
- scopus:33646827205
- ISSN
- 1083-351X
- DOI
- 10.1074/jbc.M509134200
- language
- English
- LU publication?
- yes
- id
- 6d1797a1-f48f-4ba4-ba9b-9e39ef04d83f (old id 417130)
- date added to LUP
- 2016-04-01 11:42:49
- date last changed
- 2023-01-10 17:32:58
@article{6d1797a1-f48f-4ba4-ba9b-9e39ef04d83f,
abstract = {{The cysteine protease cathepsin S is highly expressed in malignant tissues. By using a mouse model of multistage murine pancreatic islet cell carcinogenesis in which cysteine cathepsin activity has been functionally implicated, we demonstrated that selective cathepsin S deficiency impaired angiogenesis and tumor cell proliferation, thereby impairing angiogenic islet formation and the growth of solid tumors, whereas the absence of its endogenous inhibitor cystatin C resulted in opposite phenotypes. Although mitogenic vascular endothelial growth factor, transforming growth factor-beta 1, and the anti-angiogenic endostatin levels in either serum or carcinoma tissue extracts did not change in cathepsin S- or cystatin C-null mice, tumor tissue basic fibroblast growth factor and serum type 1 insulin growth factor levels were higher in cystatin C-null mice, and serum type 1 insulin growth factor levels were also increased in cathepsin S-null mice. Furthermore, cathepsin S affected the production of type IV collagen-derived anti-angiogenic peptides and the generation of bioactive pro-angiogenic gamma 2 fragments from laminin-5, revealing a functional role for cathepsin S in angiogenesis and neoplastic progression.}},
author = {{Wang, B and Sun, J S and Kitamoto, S and Yang, M and Grubb, Anders and Chapman, H A and Kalluri, R and Shi, G P}},
issn = {{1083-351X}},
language = {{eng}},
number = {{9}},
pages = {{6020--6029}},
publisher = {{American Society for Biochemistry and Molecular Biology}},
series = {{Journal of Biological Chemistry}},
title = {{Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors}},
url = {{http://dx.doi.org/10.1074/jbc.M509134200}},
doi = {{10.1074/jbc.M509134200}},
volume = {{281}},
year = {{2006}},
}