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On the neuronal circuitry mediating l-DOPA-induced dyskinesia

Cenci, M. Angela LU ; Jörntell, Henrik LU and Petersson, Per LU (2018) In Journal of Neural Transmission p.1-13
Abstract

With the advent of rodent models of l-DOPA-induced dyskinesia (LID), a growing literature has linked molecular changes in the striatum to the development and expression of abnormal involuntary movements. Changes in information processing at the striatal level are assumed to impact on the activity of downstream basal ganglia nuclei, which in turn influence brain-wide networks, but very little is actually known about systems-level mechanisms of dyskinesia. As an aid to approach this topic, we here review the anatomical and physiological organisation of cortico-basal ganglia-thalamocortical circuits, and the changes affecting these circuits in animal models of parkinsonism and LID. We then review recent findings indicating that an abnormal... (More)

With the advent of rodent models of l-DOPA-induced dyskinesia (LID), a growing literature has linked molecular changes in the striatum to the development and expression of abnormal involuntary movements. Changes in information processing at the striatal level are assumed to impact on the activity of downstream basal ganglia nuclei, which in turn influence brain-wide networks, but very little is actually known about systems-level mechanisms of dyskinesia. As an aid to approach this topic, we here review the anatomical and physiological organisation of cortico-basal ganglia-thalamocortical circuits, and the changes affecting these circuits in animal models of parkinsonism and LID. We then review recent findings indicating that an abnormal cerebellar compensation plays a causal role in LID, and that structures outside of the classical motor circuits are implicated too. In summarizing the available data, we also propose hypotheses and identify important knowledge gaps worthy of further investigation. In addition to informing novel therapeutic approaches, the study of LID can provide new clues about the interplay between different brain circuits in the control of movement.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Dopamine replacement therapy, Limbic systems, Motor systems, Movement disorders, Sensorimotor pathways
in
Journal of Neural Transmission
pages
13 pages
publisher
Springer
external identifiers
  • scopus:85046007186
ISSN
0300-9564
DOI
10.1007/s00702-018-1886-0
language
English
LU publication?
yes
id
6d2c78cc-f5e7-4014-b53b-ecb6a9f0164c
date added to LUP
2018-05-07 15:52:09
date last changed
2018-10-03 11:57:44
@article{6d2c78cc-f5e7-4014-b53b-ecb6a9f0164c,
  abstract     = {<p>With the advent of rodent models of l-DOPA-induced dyskinesia (LID), a growing literature has linked molecular changes in the striatum to the development and expression of abnormal involuntary movements. Changes in information processing at the striatal level are assumed to impact on the activity of downstream basal ganglia nuclei, which in turn influence brain-wide networks, but very little is actually known about systems-level mechanisms of dyskinesia. As an aid to approach this topic, we here review the anatomical and physiological organisation of cortico-basal ganglia-thalamocortical circuits, and the changes affecting these circuits in animal models of parkinsonism and LID. We then review recent findings indicating that an abnormal cerebellar compensation plays a causal role in LID, and that structures outside of the classical motor circuits are implicated too. In summarizing the available data, we also propose hypotheses and identify important knowledge gaps worthy of further investigation. In addition to informing novel therapeutic approaches, the study of LID can provide new clues about the interplay between different brain circuits in the control of movement.</p>},
  author       = {Cenci, M. Angela and Jörntell, Henrik and Petersson, Per},
  issn         = {0300-9564},
  keyword      = {Dopamine replacement therapy,Limbic systems,Motor systems,Movement disorders,Sensorimotor pathways},
  language     = {eng},
  month        = {04},
  pages        = {1--13},
  publisher    = {Springer},
  series       = {Journal of Neural Transmission},
  title        = {On the neuronal circuitry mediating l-DOPA-induced dyskinesia},
  url          = {http://dx.doi.org/10.1007/s00702-018-1886-0},
  year         = {2018},
}