Vulvar cancer incidence and net survival in Sweden 1960 to 2019 : A population-based national study
(2023) In Acta Obstetricia et Gynecologica Scandinavica- Abstract
Introduction: Vulvar cancer is a rare gynecological cancer affecting mostly older women. The aim of this population-based study was to investigate the incidence and net survival of vulvar cancer in Swedish women from 1960 to 2019. Material and methods: Data were retrieved from the mandatory Swedish Cancer Registry consisting of all women diagnosed with vulvar cancer between 1960 and 2019. Only women with a morphologically verified diagnosis of vulvar cancer were included. The individuals were then further matched with the Swedish Death Registry up until May 31, 2020. Results: In total, 8499 women were included with the following morphologies: squamous cell carcinoma 7250 (85.8%), malignant melanoma 539 (6.4%), adenocarcinoma 401 (4.8%)... (More)
Introduction: Vulvar cancer is a rare gynecological cancer affecting mostly older women. The aim of this population-based study was to investigate the incidence and net survival of vulvar cancer in Swedish women from 1960 to 2019. Material and methods: Data were retrieved from the mandatory Swedish Cancer Registry consisting of all women diagnosed with vulvar cancer between 1960 and 2019. Only women with a morphologically verified diagnosis of vulvar cancer were included. The individuals were then further matched with the Swedish Death Registry up until May 31, 2020. Results: In total, 8499 women were included with the following morphologies: squamous cell carcinoma 7250 (85.8%), malignant melanoma 539 (6.4%), adenocarcinoma 401 (4.8%) and other: 259 (3.1%). More than 50% of vulvar cancer cases occurred in women aged between 65 and 84 years of age. The 5-year age-standardized net survival increased from 53.0% (95% confidence interval [CI] 48.9–57.5) in 1960 to 72.1% (95% CI 68.8–75.5) in 2019. The proportion of adenocarcinoma among all cases increased from 2.0% to 8.7% between the 1960s and 2010s and an increase in age-standardized 5-year net survival was found for adenocarcinoma. Conclusions: The age-standardized incidence of vulvar cancer cases in Sweden was stable between 1960 and 2019. During the study period, an increase in adenocarcinoma and a decrease in malignant melanoma cases was found. Five-year net survival increased by 20 percent units during the study period. For squamous cell carcinoma, an increased age-specific 5-year net survival was observed for all age groups, apart for women aged ≥85.
(Less)
- author
- Moberg, Louise LU ; Sundqvist, Avalon LU ; Holmberg, Erik ; Dickman, Paul W. and Borgfeldt, Christer LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- epub
- subject
- keywords
- epidemiology, incidence, registry, survival, vulvar neoplasms
- in
- Acta Obstetricia et Gynecologica Scandinavica
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:38071449
- scopus:85178874933
- ISSN
- 0001-6349
- DOI
- 10.1111/aogs.14747
- language
- English
- LU publication?
- yes
- id
- 6d44086f-dda5-4148-bc9d-a27181650716
- date added to LUP
- 2024-01-11 11:10:24
- date last changed
- 2024-04-12 04:02:38
@article{6d44086f-dda5-4148-bc9d-a27181650716, abstract = {{<p>Introduction: Vulvar cancer is a rare gynecological cancer affecting mostly older women. The aim of this population-based study was to investigate the incidence and net survival of vulvar cancer in Swedish women from 1960 to 2019. Material and methods: Data were retrieved from the mandatory Swedish Cancer Registry consisting of all women diagnosed with vulvar cancer between 1960 and 2019. Only women with a morphologically verified diagnosis of vulvar cancer were included. The individuals were then further matched with the Swedish Death Registry up until May 31, 2020. Results: In total, 8499 women were included with the following morphologies: squamous cell carcinoma 7250 (85.8%), malignant melanoma 539 (6.4%), adenocarcinoma 401 (4.8%) and other: 259 (3.1%). More than 50% of vulvar cancer cases occurred in women aged between 65 and 84 years of age. The 5-year age-standardized net survival increased from 53.0% (95% confidence interval [CI] 48.9–57.5) in 1960 to 72.1% (95% CI 68.8–75.5) in 2019. The proportion of adenocarcinoma among all cases increased from 2.0% to 8.7% between the 1960s and 2010s and an increase in age-standardized 5-year net survival was found for adenocarcinoma. Conclusions: The age-standardized incidence of vulvar cancer cases in Sweden was stable between 1960 and 2019. During the study period, an increase in adenocarcinoma and a decrease in malignant melanoma cases was found. Five-year net survival increased by 20 percent units during the study period. For squamous cell carcinoma, an increased age-specific 5-year net survival was observed for all age groups, apart for women aged ≥85.</p>}}, author = {{Moberg, Louise and Sundqvist, Avalon and Holmberg, Erik and Dickman, Paul W. and Borgfeldt, Christer}}, issn = {{0001-6349}}, keywords = {{epidemiology; incidence; registry; survival; vulvar neoplasms}}, language = {{eng}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Obstetricia et Gynecologica Scandinavica}}, title = {{Vulvar cancer incidence and net survival in Sweden 1960 to 2019 : A population-based national study}}, url = {{http://dx.doi.org/10.1111/aogs.14747}}, doi = {{10.1111/aogs.14747}}, year = {{2023}}, }