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URB937, a peripherally-restricted inhibitor for fatty acid amide hydrolase, reduces prostaglandin E2 -induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibers in rats.

Aizawa, Naoki ; Gandaglia, Giorgio ; Hedlund, Petter LU ; Fujimura, Tetsuya ; Fukuhara, Hiroshi ; Montorsi, Francesco ; Homma, Yukio and Igawa, Yasuhiko (2015) In BJU International
Abstract
To determine if an inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) can counteract the changes in urodynamic parameters and bladder afferent activities induced by intravesical prostaglandin E2 (PGE2 )-instillation, we studied effects of URB937, a peripherally-restricted FAAH inhibitor, on single-unit afferent activity (SAA) during PGE2 -induced bladder overactivity in rats.
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BJU International
publisher
Wiley-Blackwell
external identifiers
  • pmid:26189783
  • scopus:84940173984
  • wos:000374282100024
  • pmid:26189783
ISSN
1464-4096
DOI
10.1111/bju.13223
language
English
LU publication?
yes
id
6d7dc4c3-21bb-4153-9645-9dcb539d21fd (old id 7749225)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26189783?dopt=Abstract
date added to LUP
2016-04-04 08:02:26
date last changed
2022-04-15 19:47:12
@article{6d7dc4c3-21bb-4153-9645-9dcb539d21fd,
  abstract     = {{To determine if an inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) can counteract the changes in urodynamic parameters and bladder afferent activities induced by intravesical prostaglandin E2 (PGE2 )-instillation, we studied effects of URB937, a peripherally-restricted FAAH inhibitor, on single-unit afferent activity (SAA) during PGE2 -induced bladder overactivity in rats.}},
  author       = {{Aizawa, Naoki and Gandaglia, Giorgio and Hedlund, Petter and Fujimura, Tetsuya and Fukuhara, Hiroshi and Montorsi, Francesco and Homma, Yukio and Igawa, Yasuhiko}},
  issn         = {{1464-4096}},
  language     = {{eng}},
  month        = {{07}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{BJU International}},
  title        = {{URB937, a peripherally-restricted inhibitor for fatty acid amide hydrolase, reduces prostaglandin E2 -induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibers in rats.}},
  url          = {{http://dx.doi.org/10.1111/bju.13223}},
  doi          = {{10.1111/bju.13223}},
  year         = {{2015}},
}