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Ways to unwind with HROB, a new player in homologous recombination

Saredi, Giulia LU and Rouse, John (2019) In Genes and Development 33(19-20). p.1293-1294
Abstract

Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes & Development, Hustedt and colleagues (pp. 1397–1415) reveal HROB as a new player in HR required for recruitment of the MCM8–9 complex, which is paralogous to the MCM2–7 replicative helicase. HROB functions closely with MCM8–9 to promote postsynaptic DNA repair synthesis. This study sheds valuable light on late events in HR and suggests that HROB may load MCM8–9 onto HR intermediates to facilitate the DNA unwinding required for DNA repair synthesis.

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author
and
publishing date
type
Contribution to journal
publication status
published
keywords
Cisplatin, CRISPR screens, DNA damage, DNA repair, DNA synthesis, Germ cells, Helicase, Homologous recombination
in
Genes and Development
volume
33
issue
19-20
pages
1293 - 1294
publisher
Cold Spring Harbor Laboratory Press (CSHL)
external identifiers
  • pmid:31575675
  • scopus:85072848168
ISSN
0890-9369
DOI
10.1101/gad.331850.119
language
English
LU publication?
no
additional info
Publisher Copyright: © 2019 Saredi and Rouse This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
id
6d9332d6-47c7-41b7-a401-d891533493bb
date added to LUP
2025-11-03 11:04:44
date last changed
2025-11-17 14:04:39
@article{6d9332d6-47c7-41b7-a401-d891533493bb,
  abstract     = {{<p>Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes &amp; Development, Hustedt and colleagues (pp. 1397–1415) reveal HROB as a new player in HR required for recruitment of the MCM8–9 complex, which is paralogous to the MCM2–7 replicative helicase. HROB functions closely with MCM8–9 to promote postsynaptic DNA repair synthesis. This study sheds valuable light on late events in HR and suggests that HROB may load MCM8–9 onto HR intermediates to facilitate the DNA unwinding required for DNA repair synthesis.</p>}},
  author       = {{Saredi, Giulia and Rouse, John}},
  issn         = {{0890-9369}},
  keywords     = {{Cisplatin; CRISPR screens; DNA damage; DNA repair; DNA synthesis; Germ cells; Helicase; Homologous recombination}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{19-20}},
  pages        = {{1293--1294}},
  publisher    = {{Cold Spring Harbor Laboratory Press (CSHL)}},
  series       = {{Genes and Development}},
  title        = {{Ways to unwind with HROB, a new player in homologous recombination}},
  url          = {{http://dx.doi.org/10.1101/gad.331850.119}},
  doi          = {{10.1101/gad.331850.119}},
  volume       = {{33}},
  year         = {{2019}},
}