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Preparation of diclofenac-imprinted polymer beads for selective molecular separation in water

Zhou, Tongchang LU ; Kamra, Tripta LU and Ye, Lei LU (2018) In Journal of Molecular Recognition 31(3).
Abstract

Molecular imprinting technique is an attractive strategy to prepare materials for target recognition and rapid separation. In this work, a new type of diclofenac (DFC)–imprinted polymer beads was synthesized by Pickering emulsion polymerization using 2-(dimethylamino)ethyl methacrylate as the functional monomer. The selectivity and capacity of the molecularly imprinted polymers (MIPs) were investigated in aqueous solution. Equilibrium binding results show that the MIPs have a high selectivity to bind DFC in a wide range of pH values. Moreover, in liquid chromatography experiment, the imprinted polymer beads were packed into column to investigate the binding selectivity under nonequilibrium conditions. The retention time of DFC on the... (More)

Molecular imprinting technique is an attractive strategy to prepare materials for target recognition and rapid separation. In this work, a new type of diclofenac (DFC)–imprinted polymer beads was synthesized by Pickering emulsion polymerization using 2-(dimethylamino)ethyl methacrylate as the functional monomer. The selectivity and capacity of the molecularly imprinted polymers (MIPs) were investigated in aqueous solution. Equilibrium binding results show that the MIPs have a high selectivity to bind DFC in a wide range of pH values. Moreover, in liquid chromatography experiment, the imprinted polymer beads were packed into column to investigate the binding selectivity under nonequilibrium conditions. The retention time of DFC on the MIP column is significantly longer than its structural analogues. Also, retention of DFC on the MIP column was significantly longer than on the nonimprinted polymer column under aqueous condition. As the new MIP beads can be used to achieve direct separation of DFC from water, the synthetic method and the affinity beads developed in this work opened new possibilities for removing toxic chemicals from environmental and drinking water.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
aqueous condition, diclofenac, molecular separation, molecularly imprinted polymer beads
in
Journal of Molecular Recognition
volume
31
issue
3
publisher
John Wiley & Sons
external identifiers
  • scopus:85041958632
ISSN
0952-3499
DOI
10.1002/jmr.2608
language
English
LU publication?
yes
id
6da6819d-3760-474a-8c41-30fc148c9641
date added to LUP
2018-02-20 12:26:29
date last changed
2018-05-29 10:09:53
@article{6da6819d-3760-474a-8c41-30fc148c9641,
  abstract     = {<p>Molecular imprinting technique is an attractive strategy to prepare materials for target recognition and rapid separation. In this work, a new type of diclofenac (DFC)–imprinted polymer beads was synthesized by Pickering emulsion polymerization using 2-(dimethylamino)ethyl methacrylate as the functional monomer. The selectivity and capacity of the molecularly imprinted polymers (MIPs) were investigated in aqueous solution. Equilibrium binding results show that the MIPs have a high selectivity to bind DFC in a wide range of pH values. Moreover, in liquid chromatography experiment, the imprinted polymer beads were packed into column to investigate the binding selectivity under nonequilibrium conditions. The retention time of DFC on the MIP column is significantly longer than its structural analogues. Also, retention of DFC on the MIP column was significantly longer than on the nonimprinted polymer column under aqueous condition. As the new MIP beads can be used to achieve direct separation of DFC from water, the synthetic method and the affinity beads developed in this work opened new possibilities for removing toxic chemicals from environmental and drinking water.</p>},
  articleno    = {e2608},
  author       = {Zhou, Tongchang and Kamra, Tripta and Ye, Lei},
  issn         = {0952-3499},
  keyword      = {aqueous condition,diclofenac,molecular separation,molecularly imprinted polymer beads},
  language     = {eng},
  month        = {03},
  number       = {3},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Molecular Recognition},
  title        = {Preparation of diclofenac-imprinted polymer beads for selective molecular separation in water},
  url          = {http://dx.doi.org/10.1002/jmr.2608},
  volume       = {31},
  year         = {2018},
}