Dural administration of inflammatory soup or Complete Freund's Adjuvant induces activation and inflammatory response in the rat trigeminal ganglion.
Lukács, Melinda LU ; Haanes, K A ; Majláth, Zs ; Tajti, J ; Vécsei, L ; Warfvinge, Karin LU
and Edvinsson, Lars
LU
(2015)
In Journal of Headache and Pain
16.
- Abstract
- Migraine is a painful disorder with a huge impact on individual and public health. We hypothesize that migraine pain originates from a central mechanism that results secondarily in hypersensitivity in peripheral afferents associated with the cerebral and cranial blood vessels. It has previously been shown that application of inflammatory or algesic substances onto the dura mater or chemical stimulation of the dural receptive fields causes hypersensitivity to mechanical and thermal stimulation together with direct activation of the TG. We asked whether local inflammation of dura mater induces inflammatory activation in the trigeminal ganglion.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8043508
- author
- Lukács, Melinda
LU
; Haanes, K A
; Majláth, Zs
; Tajti, J
; Vécsei, L
; Warfvinge, Karin
LU
and Edvinsson, Lars
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Headache and Pain
- volume
- 16
- article number
- 79
- publisher
- Springer
- external identifiers
-
- pmid:26329487
- wos:000368624000001
- scopus:84940999121
- pmid:26329487
- ISSN
- 1129-2369
- DOI
- 10.1186/s10194-015-0564-y
- language
- English
- LU publication?
- yes
- id
- 6da7291d-c51e-423c-860f-47f981d8620f (old id 8043508)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26329487?dopt=Abstract
- date added to LUP
- 2016-04-01 09:58:03
- date last changed
- 2024-11-03 19:47:36
@article{6da7291d-c51e-423c-860f-47f981d8620f,
abstract = {{Migraine is a painful disorder with a huge impact on individual and public health. We hypothesize that migraine pain originates from a central mechanism that results secondarily in hypersensitivity in peripheral afferents associated with the cerebral and cranial blood vessels. It has previously been shown that application of inflammatory or algesic substances onto the dura mater or chemical stimulation of the dural receptive fields causes hypersensitivity to mechanical and thermal stimulation together with direct activation of the TG. We asked whether local inflammation of dura mater induces inflammatory activation in the trigeminal ganglion.}},
author = {{Lukács, Melinda and Haanes, K A and Majláth, Zs and Tajti, J and Vécsei, L and Warfvinge, Karin and Edvinsson, Lars}},
issn = {{1129-2369}},
language = {{eng}},
publisher = {{Springer}},
series = {{Journal of Headache and Pain}},
title = {{Dural administration of inflammatory soup or Complete Freund's Adjuvant induces activation and inflammatory response in the rat trigeminal ganglion.}},
url = {{http://dx.doi.org/10.1186/s10194-015-0564-y}},
doi = {{10.1186/s10194-015-0564-y}},
volume = {{16}},
year = {{2015}},
}