Microbiome changes : an indicator of Parkinson's disease?
(2019) In Translational Neurodegeneration 8(38).- Abstract
Parkinson's disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of pathogenesis is still obscure. In recent years, more attention has been given to the gut as a key player in the initiation and progression of PD pathology. Several studies characterizing changes in the microbiome, particularly the gut microbiome, have been conducted. Although many studies found a decrease in the bacterial family Prevotellaceae and in butyrate-producing bacterial genera such as Roseburia and Faecalibacteria, and an increase in the genera Akkermansia many of the studies reported contradictory findings. In this review, we highlight the findings from the different... (More)
Parkinson's disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of pathogenesis is still obscure. In recent years, more attention has been given to the gut as a key player in the initiation and progression of PD pathology. Several studies characterizing changes in the microbiome, particularly the gut microbiome, have been conducted. Although many studies found a decrease in the bacterial family Prevotellaceae and in butyrate-producing bacterial genera such as Roseburia and Faecalibacteria, and an increase in the genera Akkermansia many of the studies reported contradictory findings. In this review, we highlight the findings from the different studies and reflect on the future of microbiome studies in PD research.
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- author
- Haikal, Caroline LU ; Chen, Qian-Qian and Li, Jia-Yi LU
- organization
- publishing date
- 2019-12-24
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Parkinson’s disease, Intestinal microbiota, Inflammation, Gut, Protein aggregation
- in
- Translational Neurodegeneration
- volume
- 8
- issue
- 38
- pages
- 9 pages
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85077026454
- pmid:31890161
- ISSN
- 2047-9158
- DOI
- 10.1186/s40035-019-0175-7
- language
- English
- LU publication?
- yes
- id
- 6ddeb20d-5b39-4261-978b-bfa6575fc6e1
- date added to LUP
- 2021-06-28 16:37:39
- date last changed
- 2024-04-06 05:31:45
@article{6ddeb20d-5b39-4261-978b-bfa6575fc6e1,
abstract = {{<p>Parkinson's disease is characterized by dopaminergic neuron loss and intracellular inclusions composed mainly of alpha synuclein (α-syn), but the mechanism of pathogenesis is still obscure. In recent years, more attention has been given to the gut as a key player in the initiation and progression of PD pathology. Several studies characterizing changes in the microbiome, particularly the gut microbiome, have been conducted. Although many studies found a decrease in the bacterial family Prevotellaceae and in butyrate-producing bacterial genera such as Roseburia and Faecalibacteria, and an increase in the genera Akkermansia many of the studies reported contradictory findings. In this review, we highlight the findings from the different studies and reflect on the future of microbiome studies in PD research.</p>}},
author = {{Haikal, Caroline and Chen, Qian-Qian and Li, Jia-Yi}},
issn = {{2047-9158}},
keywords = {{Parkinson’s disease; Intestinal microbiota; Inflammation; Gut; Protein aggregation}},
language = {{eng}},
month = {{12}},
number = {{38}},
publisher = {{BioMed Central (BMC)}},
series = {{Translational Neurodegeneration}},
title = {{Microbiome changes : an indicator of Parkinson's disease?}},
url = {{http://dx.doi.org/10.1186/s40035-019-0175-7}},
doi = {{10.1186/s40035-019-0175-7}},
volume = {{8}},
year = {{2019}},
}