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Transcription factor 7-like 2 (TCF7L2)

Grant, Struan F A and Groop, Leif LU (2016) In The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation p.297-316
Abstract

In 2006 a genetic signal within the gene encoding transcription factor 7-like 2 (TCF7L2) was first reported to be associated with type 2 diabetes. Since then multiple genome-wide association studies have revealed this signal to be among the most strongest associations reported with this disease to date. Furthermore, multiple studies around the world have revealed the global relevance of this locus in intron 3 of the gene and have helped pinpoint, with relative confidence, the causal lesion at this locus. However, despite this association being beyond doubt, there is still a lack of consensus with respect to mechanisms of action and which tissue(s) it actually exerts its influence on the pathogenesis of type 2 diabetes.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation
pages
20 pages
publisher
Springer International Publishing
external identifiers
  • scopus:84978218406
ISBN
9783319015743
9783319015736
DOI
10.1007/978-3-319-01574-3_14
language
English
LU publication?
yes
id
6debe321-1013-4869-bf3a-4c39e6e858a5
date added to LUP
2016-08-10 16:48:01
date last changed
2017-04-20 09:11:19
@inbook{6debe321-1013-4869-bf3a-4c39e6e858a5,
  abstract     = {<p>In 2006 a genetic signal within the gene encoding transcription factor 7-like 2 (TCF7L2) was first reported to be associated with type 2 diabetes. Since then multiple genome-wide association studies have revealed this signal to be among the most strongest associations reported with this disease to date. Furthermore, multiple studies around the world have revealed the global relevance of this locus in intron 3 of the gene and have helped pinpoint, with relative confidence, the causal lesion at this locus. However, despite this association being beyond doubt, there is still a lack of consensus with respect to mechanisms of action and which tissue(s) it actually exerts its influence on the pathogenesis of type 2 diabetes.</p>},
  author       = {Grant, Struan F A and Groop, Leif},
  isbn         = {9783319015743},
  language     = {eng},
  month        = {01},
  pages        = {297--316},
  publisher    = {Springer International Publishing},
  series       = {The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation},
  title        = {Transcription factor 7-like 2 (TCF7L2)},
  url          = {http://dx.doi.org/10.1007/978-3-319-01574-3_14},
  year         = {2016},
}