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Updated Pathways in Cardiorenal Continuum after Kidney Transplantation

Laučytė-Cibulskienė, Agnė LU orcid ; Biglarnia, Ali Reza ; Wallquist, Carin LU and Christensson, Anders LU (2022) In Transplantology 3(2). p.156-168
Abstract

Cardiovascular disease (CVD) remains one of the leading causes for increased morbidity and mortality in chronic kidney disease (CKD). Kidney transplantation is the preferred treatment option for CKD G5. Improved perioperative and postoperative care, personalized immunosuppressive regimes, and refined matching procedures of kidney transplants improves cardiovascular health in the early posttransplant period. However, the long-term burden of CVD is considerable. Previously underrecognized, the role of the complement system alongside innate immunity, inflammaging, structural changes in the glomerular filtration barrier and early vascular ageing also seem to play an important role in the posttransplant management. This review provides... (More)

Cardiovascular disease (CVD) remains one of the leading causes for increased morbidity and mortality in chronic kidney disease (CKD). Kidney transplantation is the preferred treatment option for CKD G5. Improved perioperative and postoperative care, personalized immunosuppressive regimes, and refined matching procedures of kidney transplants improves cardiovascular health in the early posttransplant period. However, the long-term burden of CVD is considerable. Previously underrecognized, the role of the complement system alongside innate immunity, inflammaging, structural changes in the glomerular filtration barrier and early vascular ageing also seem to play an important role in the posttransplant management. This review provides up-to-date knowledge on these pathways that may influence the cardiovascular and renal continuum and identifies potential targets for future therapies. Arterial destiffening strategies and the applicability of sodium-glucose cotransporter 2 inhibitors and their role in cardiovascular health after kidney transplantation are also addressed.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
arterial stiffness, complement system, cystatin C, kidney transplant, microbiome, sodium-glucose cotransporter 2 inhibitors
in
Transplantology
volume
3
issue
2
pages
13 pages
publisher
MDPI AG
external identifiers
  • scopus:85145236408
ISSN
2673-3943
DOI
10.3390/transplantology3020017
language
English
LU publication?
yes
id
6e0c76b8-14c8-4a9a-b7d9-837cc50beaad
date added to LUP
2023-01-16 16:53:33
date last changed
2023-01-24 14:26:28
@article{6e0c76b8-14c8-4a9a-b7d9-837cc50beaad,
  abstract     = {{<p>Cardiovascular disease (CVD) remains one of the leading causes for increased morbidity and mortality in chronic kidney disease (CKD). Kidney transplantation is the preferred treatment option for CKD G5. Improved perioperative and postoperative care, personalized immunosuppressive regimes, and refined matching procedures of kidney transplants improves cardiovascular health in the early posttransplant period. However, the long-term burden of CVD is considerable. Previously underrecognized, the role of the complement system alongside innate immunity, inflammaging, structural changes in the glomerular filtration barrier and early vascular ageing also seem to play an important role in the posttransplant management. This review provides up-to-date knowledge on these pathways that may influence the cardiovascular and renal continuum and identifies potential targets for future therapies. Arterial destiffening strategies and the applicability of sodium-glucose cotransporter 2 inhibitors and their role in cardiovascular health after kidney transplantation are also addressed.</p>}},
  author       = {{Laučytė-Cibulskienė, Agnė and Biglarnia, Ali Reza and Wallquist, Carin and Christensson, Anders}},
  issn         = {{2673-3943}},
  keywords     = {{arterial stiffness; complement system; cystatin C; kidney transplant; microbiome; sodium-glucose cotransporter 2 inhibitors}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{156--168}},
  publisher    = {{MDPI AG}},
  series       = {{Transplantology}},
  title        = {{Updated Pathways in Cardiorenal Continuum after Kidney Transplantation}},
  url          = {{http://dx.doi.org/10.3390/transplantology3020017}},
  doi          = {{10.3390/transplantology3020017}},
  volume       = {{3}},
  year         = {{2022}},
}