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On the regional distribution of cerebral microvascular ‘raspberries’ and their association with cerebral atherosclerosis and acute circulatory failure

Ek Olofsson, Henric LU orcid ; Haglund, Mattias LU and Englund, Elisabet LU orcid (2023) In Cerebral Circulation - Cognition and Behavior 4. p.1-5
Abstract
Introduction
In this follow-up study, cerebral microvascular formations termed ‘raspberries’ were quantified according to cerebral atherosclerosis (C-ASCL) and acute circulatory failure (ACF). We also examined the regional distribution of raspberries throughout the brain.

Materials and methods
The study population consisted of adult individuals who had undergone a diagnostic neuropathological autopsy. Groups were formed to examine the association between raspberries, C-ASCL and ACF (control group, C-ASCL group, C-ASCL+ACF group [n = 47 per group] and a combined C-ASCL-tot group [n = 94]). To examine the regional distribution, additional groups were formed based on previously known raspberry densities of the frontal cortex... (More)
Introduction
In this follow-up study, cerebral microvascular formations termed ‘raspberries’ were quantified according to cerebral atherosclerosis (C-ASCL) and acute circulatory failure (ACF). We also examined the regional distribution of raspberries throughout the brain.

Materials and methods
The study population consisted of adult individuals who had undergone a diagnostic neuropathological autopsy. Groups were formed to examine the association between raspberries, C-ASCL and ACF (control group, C-ASCL group, C-ASCL+ACF group [n = 47 per group] and a combined C-ASCL-tot group [n = 94]). To examine the regional distribution, additional groups were formed based on previously known raspberry densities of the frontal cortex (high-, medium- and low-density group [n = 6 per group]). Raspberries were quantified on scanned haematoxylin-eosin-stained sections.

Results
Cortical raspberry density did not differ at a statistically significant level between the control group, the C-ASCL group and the C-ASCL+ACF group (P = 0.10) but did so between the control group and the C-ASCL-tot group (P = 0.033). The total raspberry density of the high-, medium- and low-density groups differed at a statistically significant level (P = 0.005), which remained in group-to-group comparisons of the high- and medium-density groups (P = 0.015) and the high- and low-density groups (P = 0.002). Raspberries were rare in cerebral white matter and in the cerebellum.

Conclusion
An association between raspberry density and C-ASCL is supported but is weaker than previously indicated. An association with ACF is not indicated. The raspberry density of the frontal cortex provides an approximation of the brain's total raspberry density. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cerebral Circulation - Cognition and Behavior
volume
4
article number
100157
pages
1 - 5
publisher
Elsevier
external identifiers
  • scopus:85146358697
  • pmid:36691600
ISSN
2666-2450
DOI
10.1016/j.cccb.2023.100157
project
A new type of microvascular formation in the cerebral cortex – is there a link to cerebral hypoperfusion?
language
English
LU publication?
yes
id
6e512252-d624-486a-b873-5d3f0a131781
date added to LUP
2023-01-10 20:31:07
date last changed
2024-05-16 08:46:52
@article{6e512252-d624-486a-b873-5d3f0a131781,
  abstract     = {{Introduction<br/>In this follow-up study, cerebral microvascular formations termed ‘raspberries’ were quantified according to cerebral atherosclerosis (C-ASCL) and acute circulatory failure (ACF). We also examined the regional distribution of raspberries throughout the brain.<br/><br/>Materials and methods<br/>The study population consisted of adult individuals who had undergone a diagnostic neuropathological autopsy. Groups were formed to examine the association between raspberries, C-ASCL and ACF (control group, C-ASCL group, C-ASCL+ACF group [n = 47 per group] and a combined C-ASCL-tot group [n = 94]). To examine the regional distribution, additional groups were formed based on previously known raspberry densities of the frontal cortex (high-, medium- and low-density group [n = 6 per group]). Raspberries were quantified on scanned haematoxylin-eosin-stained sections.<br/><br/>Results<br/>Cortical raspberry density did not differ at a statistically significant level between the control group, the C-ASCL group and the C-ASCL+ACF group (P = 0.10) but did so between the control group and the C-ASCL-tot group (P = 0.033). The total raspberry density of the high-, medium- and low-density groups differed at a statistically significant level (P = 0.005), which remained in group-to-group comparisons of the high- and medium-density groups (P = 0.015) and the high- and low-density groups (P = 0.002). Raspberries were rare in cerebral white matter and in the cerebellum.<br/><br/>Conclusion<br/>An association between raspberry density and C-ASCL is supported but is weaker than previously indicated. An association with ACF is not indicated. The raspberry density of the frontal cortex provides an approximation of the brain's total raspberry density.}},
  author       = {{Ek Olofsson, Henric and Haglund, Mattias and Englund, Elisabet}},
  issn         = {{2666-2450}},
  language     = {{eng}},
  month        = {{01}},
  pages        = {{1--5}},
  publisher    = {{Elsevier}},
  series       = {{Cerebral Circulation - Cognition and Behavior}},
  title        = {{On the regional distribution of cerebral microvascular ‘raspberries’ and their association with cerebral atherosclerosis and acute circulatory failure}},
  url          = {{http://dx.doi.org/10.1016/j.cccb.2023.100157}},
  doi          = {{10.1016/j.cccb.2023.100157}},
  volume       = {{4}},
  year         = {{2023}},
}