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Mitochondrial complex I and V gene polymorphisms in type II diabetes mellitus among high risk Mizo-Mongoloid population, Northeast India

Lalrohlui, Freda ; Thapa, Sunaina ; Ghatak, Souvik LU ; Zohmingthanga, John and Kumar, Nachimuthu Senthil (2016) In Genes and Environment 38. p.1-6
Abstract
Introduction
The study was carried out to identify the polymorphisms in mitochondrial genes (ATPase and ND1) in type 2 Diabetes Mellitus (T2DM) from Mizo population and to correlate the involvement of demographic factors.

Findings
In the present study, 58 patients and 50 healthy volunteers were considered. The mutations observed were mostly base substitutions and were similar as reported for other populations. Three mutations are unreported and were found to be novel polymorphisms for diabetic disease. One heteroplasmic variation (MT3970 C > T) was found in 36.36 % of samples. Subjects with excessive smoked meat consumption and customary habit of smoking (ORs: 4.92; 95 % CI: 0.96–25.21) were found to be more prone to... (More)
Introduction
The study was carried out to identify the polymorphisms in mitochondrial genes (ATPase and ND1) in type 2 Diabetes Mellitus (T2DM) from Mizo population and to correlate the involvement of demographic factors.

Findings
In the present study, 58 patients and 50 healthy volunteers were considered. The mutations observed were mostly base substitutions and were similar as reported for other populations. Three mutations are unreported and were found to be novel polymorphisms for diabetic disease. One heteroplasmic variation (MT3970 C > T) was found in 36.36 % of samples. Subjects with excessive smoked meat consumption and customary habit of smoking (ORs: 4.92; 95 % CI: 0.96–25.21) were found to be more prone to T2DM. Mitochondrial genes sequence analysis revealed the genetic variability between the healthy and diabetic samples.

Conclusion
Mitochondrial ATPase and ND1 gene polymorphisms may be involved in triggering the risk for T2DM. (Less)
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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Genes and Environment
volume
38
pages
1 - 6
publisher
BioMed Central (BMC)
external identifiers
  • scopus:84973562779
ISSN
1880-7062
DOI
10.1186/s41021-016-0034-z
language
English
LU publication?
no
id
6e93b6e5-21a5-42ac-bb48-b43ae7afcd49
date added to LUP
2021-11-09 16:12:24
date last changed
2022-02-02 01:11:02
@article{6e93b6e5-21a5-42ac-bb48-b43ae7afcd49,
  abstract     = {{Introduction<br/>The study was carried out to identify the polymorphisms in mitochondrial genes (ATPase and ND1) in type 2 Diabetes Mellitus (T2DM) from Mizo population and to correlate the involvement of demographic factors.<br/><br/>Findings<br/>In the present study, 58 patients and 50 healthy volunteers were considered. The mutations observed were mostly base substitutions and were similar as reported for other populations. Three mutations are unreported and were found to be novel polymorphisms for diabetic disease. One heteroplasmic variation (MT3970 C &gt; T) was found in 36.36 % of samples. Subjects with excessive smoked meat consumption and customary habit of smoking (ORs: 4.92; 95 % CI: 0.96–25.21) were found to be more prone to T2DM. Mitochondrial genes sequence analysis revealed the genetic variability between the healthy and diabetic samples.<br/><br/>Conclusion<br/>Mitochondrial ATPase and ND1 gene polymorphisms may be involved in triggering the risk for T2DM.}},
  author       = {{Lalrohlui, Freda and Thapa, Sunaina and Ghatak, Souvik and Zohmingthanga, John and Kumar, Nachimuthu Senthil}},
  issn         = {{1880-7062}},
  language     = {{eng}},
  pages        = {{1--6}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Genes and Environment}},
  title        = {{Mitochondrial complex I and V gene polymorphisms in type II diabetes mellitus among high risk Mizo-Mongoloid population, Northeast India}},
  url          = {{http://dx.doi.org/10.1186/s41021-016-0034-z}},
  doi          = {{10.1186/s41021-016-0034-z}},
  volume       = {{38}},
  year         = {{2016}},
}