Brain natriuretic peptide is related to diastolic dysfunction whereas urinary albumin excretion rate is related to left ventricular mass in asymptomatic type 2 diabetes patients
Magnusson, Martin LU
; Jovinge, Stefan
LU
; Shahgaldi, Kambiz
; Israelsson, Bo
LU
; Groop, Leif
LU
and Melander, Olle
LU
(2010)
In Cardiovascular Diabetology
9.
- Abstract
- Background: The aims of this study were to estimate the prevalence of left ventricular systolic (LVSD) and diastolic (LVDD) dysfunction, and to test if BNP and urinary albumin excretion rate (AER) are related to LVSD, LVD and left ventricular mass (LVM) in asymptomatic type 2 diabetes patients. Methods: Presence of LVSD, LVDD and LVM, determined with echocardiography, was related to levels of BNP and AER in 153 consecutive asymptomatic patients with type 2 diabetes. Results: LVSD was present in 6.1% of patients whereas 49% (29% mild, 19% moderate and 0.7% severe) had LVDD and 9.4% had left ventricular hypertrophy. Increasing age (P < 0.0001) was the only independent variable related to mild LVDD whereas increasing BNP (P = 0.01),... (More)
- Background: The aims of this study were to estimate the prevalence of left ventricular systolic (LVSD) and diastolic (LVDD) dysfunction, and to test if BNP and urinary albumin excretion rate (AER) are related to LVSD, LVD and left ventricular mass (LVM) in asymptomatic type 2 diabetes patients. Methods: Presence of LVSD, LVDD and LVM, determined with echocardiography, was related to levels of BNP and AER in 153 consecutive asymptomatic patients with type 2 diabetes. Results: LVSD was present in 6.1% of patients whereas 49% (29% mild, 19% moderate and 0.7% severe) had LVDD and 9.4% had left ventricular hypertrophy. Increasing age (P < 0.0001) was the only independent variable related to mild LVDD whereas increasing BNP (P = 0.01), systolic blood pressure (P = 0.01), age (P = 0.003) and female gender (P = 0.04) were independent determinants of moderate to severe LVDD. AER (P = 0.003), age (P = 0.01) and male gender (P = 0.006) were directly and independently related to LVM. Conclusion: About half of asymptomatic type 2 diabetes patients have LVDD. Of those, more than one third display moderate LVDD pattern paralleled by increases in BNP, suggesting markedly increased risk of heart failure, especially in females, whereas AER and male sex are related to LVM. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1568643
- author
- Magnusson, Martin
LU
; Jovinge, Stefan
LU
; Shahgaldi, Kambiz
; Israelsson, Bo
LU
; Groop, Leif
LU
and Melander, Olle
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cardiovascular Diabetology
- volume
- 9
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000274691300001
- scopus:76749105232
- ISSN
- 1475-2840
- DOI
- 10.1186/1475-2840-9-2
- project
- Kompetens centrum Hjärta och Diabetes - KHD
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hypertension and Cardiovascular Disease (013242540), Diabetes and Endocrinology (013241530), Hematopoietic Stem Cell Laboratory (013022012), Emergency medicine/Medicine/Surgery (013240200)
- id
- 6ea84676-4a50-4513-b4db-92902086d4e1 (old id 1568643)
- date added to LUP
- 2016-04-01 13:42:17
- date last changed
- 2024-03-13 10:39:33
@article{6ea84676-4a50-4513-b4db-92902086d4e1,
abstract = {{Background: The aims of this study were to estimate the prevalence of left ventricular systolic (LVSD) and diastolic (LVDD) dysfunction, and to test if BNP and urinary albumin excretion rate (AER) are related to LVSD, LVD and left ventricular mass (LVM) in asymptomatic type 2 diabetes patients. Methods: Presence of LVSD, LVDD and LVM, determined with echocardiography, was related to levels of BNP and AER in 153 consecutive asymptomatic patients with type 2 diabetes. Results: LVSD was present in 6.1% of patients whereas 49% (29% mild, 19% moderate and 0.7% severe) had LVDD and 9.4% had left ventricular hypertrophy. Increasing age (P < 0.0001) was the only independent variable related to mild LVDD whereas increasing BNP (P = 0.01), systolic blood pressure (P = 0.01), age (P = 0.003) and female gender (P = 0.04) were independent determinants of moderate to severe LVDD. AER (P = 0.003), age (P = 0.01) and male gender (P = 0.006) were directly and independently related to LVM. Conclusion: About half of asymptomatic type 2 diabetes patients have LVDD. Of those, more than one third display moderate LVDD pattern paralleled by increases in BNP, suggesting markedly increased risk of heart failure, especially in females, whereas AER and male sex are related to LVM.}},
author = {{Magnusson, Martin and Jovinge, Stefan and Shahgaldi, Kambiz and Israelsson, Bo and Groop, Leif and Melander, Olle}},
issn = {{1475-2840}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{Cardiovascular Diabetology}},
title = {{Brain natriuretic peptide is related to diastolic dysfunction whereas urinary albumin excretion rate is related to left ventricular mass in asymptomatic type 2 diabetes patients}},
url = {{http://dx.doi.org/10.1186/1475-2840-9-2}},
doi = {{10.1186/1475-2840-9-2}},
volume = {{9}},
year = {{2010}},
}