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New hallmarks of ageing : a 2022 Copenhagen ageing meeting summary

Schmauck-Medina, Tomas ; Molière, Adrian ; Lautrup, Sofie ; Zhang, Jianying ; Chlopicki, Stefan ; Madsen, Helena Borland ; Cao, Shuqin ; Soendenbroe, Casper ; Mansell, Els LU and Vestergaard, Mark Bitsch , et al. (2022) In Aging 14(16). p.6829-6839
Abstract

Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of... (More)

Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the ‘old’ and ‘new’ hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Autophagy, Hallmarks of ageing, Healthspan, Longevity, Neurodegeneration
in
Aging
volume
14
issue
16
pages
11 pages
publisher
Impact Journals
external identifiers
  • pmid:36040386
  • scopus:85137298030
ISSN
1945-4589
DOI
10.18632/aging.204248
language
English
LU publication?
yes
id
6ebb2310-6dc7-40c4-bd2a-5abfc5c2b0ba
date added to LUP
2022-11-21 14:26:21
date last changed
2024-04-19 19:25:02
@article{6ebb2310-6dc7-40c4-bd2a-5abfc5c2b0ba,
  abstract     = {{<p>Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the ‘old’ and ‘new’ hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.</p>}},
  author       = {{Schmauck-Medina, Tomas and Molière, Adrian and Lautrup, Sofie and Zhang, Jianying and Chlopicki, Stefan and Madsen, Helena Borland and Cao, Shuqin and Soendenbroe, Casper and Mansell, Els and Vestergaard, Mark Bitsch and Li, Zhiquan and Shiloh, Yosef and Opresko, Patricia L. and Egly, Jean Marc and Kirkwood, Thomas and Verdin, Eric and Bohr, Vilhelm A. and Cox, Lynne S. and Stevnsner, Tinna and Rasmussen, Lene Juel and Fang, Evandro F.}},
  issn         = {{1945-4589}},
  keywords     = {{Autophagy; Hallmarks of ageing; Healthspan; Longevity; Neurodegeneration}},
  language     = {{eng}},
  number       = {{16}},
  pages        = {{6829--6839}},
  publisher    = {{Impact Journals}},
  series       = {{Aging}},
  title        = {{New hallmarks of ageing : a 2022 Copenhagen ageing meeting summary}},
  url          = {{http://dx.doi.org/10.18632/aging.204248}},
  doi          = {{10.18632/aging.204248}},
  volume       = {{14}},
  year         = {{2022}},
}