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Risk Factors for Stroke in Subjects With Normal Blood Pressure. A Prospective Cohort Study.

Li, Cairu LU ; Engström, Gunnar LU ; Hedblad, Bo LU ; Berglund, Göran LU and Janzon, Lars LU (2005) In Stroke: a journal of cerebral circulation 36(2). p.234-238
Abstract
Background and Purpose— Although stroke is strongly associated with hypertension, some individuals with normal blood pressure (BP) experience a stroke. This prospective study explored risk factors for stroke in subjects with normal BP.



Methods— A total of 11 228 men and 17 174 women, 45 to 73 years old, were examined in a population-based cohort study. Normal BP was defined as BP <140/90 mm Hg and no treatment for hypertension. The incidence of stroke was followed over a mean period of 6 years.



Results— In the cohort, 10 938 (38%) had normal BP. Of them, 56 patients experienced a first-ever stroke (12% of all stroke). Compared with subjects without stroke during follow-up, these stroke subjects were... (More)
Background and Purpose— Although stroke is strongly associated with hypertension, some individuals with normal blood pressure (BP) experience a stroke. This prospective study explored risk factors for stroke in subjects with normal BP.



Methods— A total of 11 228 men and 17 174 women, 45 to 73 years old, were examined in a population-based cohort study. Normal BP was defined as BP <140/90 mm Hg and no treatment for hypertension. The incidence of stroke was followed over a mean period of 6 years.



Results— In the cohort, 10 938 (38%) had normal BP. Of them, 56 patients experienced a first-ever stroke (12% of all stroke). Compared with subjects without stroke during follow-up, these stroke subjects were older, had lower education, were often smokers and alcohol nondrinkers, and had a history of coronary heart disease (CHD), gastric ulcer, or renal calculus. Subjects with stroke had a higher body mass index (BMI) and a high-normal BP (130 to 139/85 to 89 mm Hg) more often. In a backward stepwise Cox-regression analysis, age (per 1 year; relative risk [RR], 1.12), current smoking (RR, 3.21), BMI (per SD; RR, 1.39), high-normal diastolic BP (RR, 2.35), history of CHD (RR, 4.92), and gastric ulcer (RR, 2.21) remained significantly associated with incidence of stroke.



Conclusion— In subjects with normal BP, there are a number of potentially modifiable risk factors associated with an increased incidence of stroke. (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
risk factors, stroke, blood pressure
in
Stroke: a journal of cerebral circulation
volume
36
issue
2
pages
234 - 238
publisher
American Heart Association
external identifiers
  • wos:000226507600029
  • pmid:15618439
  • scopus:12844275885
ISSN
1524-4628
DOI
10.1161/01.STR.0000152328.66493.0a
language
English
LU publication?
yes
id
6edac589-ed47-4664-863e-802832230fbb (old id 131847)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15618439&dopt=Abstract
date added to LUP
2016-04-01 16:42:07
date last changed
2022-02-20 07:43:24
@article{6edac589-ed47-4664-863e-802832230fbb,
  abstract     = {{Background and Purpose— Although stroke is strongly associated with hypertension, some individuals with normal blood pressure (BP) experience a stroke. This prospective study explored risk factors for stroke in subjects with normal BP.<br/><br>
<br/><br>
Methods— A total of 11 228 men and 17 174 women, 45 to 73 years old, were examined in a population-based cohort study. Normal BP was defined as BP &lt;140/90 mm Hg and no treatment for hypertension. The incidence of stroke was followed over a mean period of 6 years.<br/><br>
<br/><br>
Results— In the cohort, 10 938 (38%) had normal BP. Of them, 56 patients experienced a first-ever stroke (12% of all stroke). Compared with subjects without stroke during follow-up, these stroke subjects were older, had lower education, were often smokers and alcohol nondrinkers, and had a history of coronary heart disease (CHD), gastric ulcer, or renal calculus. Subjects with stroke had a higher body mass index (BMI) and a high-normal BP (130 to 139/85 to 89 mm Hg) more often. In a backward stepwise Cox-regression analysis, age (per 1 year; relative risk [RR], 1.12), current smoking (RR, 3.21), BMI (per SD; RR, 1.39), high-normal diastolic BP (RR, 2.35), history of CHD (RR, 4.92), and gastric ulcer (RR, 2.21) remained significantly associated with incidence of stroke.<br/><br>
<br/><br>
Conclusion— In subjects with normal BP, there are a number of potentially modifiable risk factors associated with an increased incidence of stroke.}},
  author       = {{Li, Cairu and Engström, Gunnar and Hedblad, Bo and Berglund, Göran and Janzon, Lars}},
  issn         = {{1524-4628}},
  keywords     = {{risk factors; stroke; blood pressure}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{234--238}},
  publisher    = {{American Heart Association}},
  series       = {{Stroke: a journal of cerebral circulation}},
  title        = {{Risk Factors for Stroke in Subjects With Normal Blood Pressure. A Prospective Cohort Study.}},
  url          = {{http://dx.doi.org/10.1161/01.STR.0000152328.66493.0a}},
  doi          = {{10.1161/01.STR.0000152328.66493.0a}},
  volume       = {{36}},
  year         = {{2005}},
}