Risk Factors for Stroke in Subjects With Normal Blood Pressure. A Prospective Cohort Study.
(2005) In Stroke: a journal of cerebral circulation 36(2). p.234-238- Abstract
- Background and Purpose— Although stroke is strongly associated with hypertension, some individuals with normal blood pressure (BP) experience a stroke. This prospective study explored risk factors for stroke in subjects with normal BP.
Methods— A total of 11 228 men and 17 174 women, 45 to 73 years old, were examined in a population-based cohort study. Normal BP was defined as BP <140/90 mm Hg and no treatment for hypertension. The incidence of stroke was followed over a mean period of 6 years.
Results— In the cohort, 10 938 (38%) had normal BP. Of them, 56 patients experienced a first-ever stroke (12% of all stroke). Compared with subjects without stroke during follow-up, these stroke subjects were... (More) - Background and Purpose— Although stroke is strongly associated with hypertension, some individuals with normal blood pressure (BP) experience a stroke. This prospective study explored risk factors for stroke in subjects with normal BP.
Methods— A total of 11 228 men and 17 174 women, 45 to 73 years old, were examined in a population-based cohort study. Normal BP was defined as BP <140/90 mm Hg and no treatment for hypertension. The incidence of stroke was followed over a mean period of 6 years.
Results— In the cohort, 10 938 (38%) had normal BP. Of them, 56 patients experienced a first-ever stroke (12% of all stroke). Compared with subjects without stroke during follow-up, these stroke subjects were older, had lower education, were often smokers and alcohol nondrinkers, and had a history of coronary heart disease (CHD), gastric ulcer, or renal calculus. Subjects with stroke had a higher body mass index (BMI) and a high-normal BP (130 to 139/85 to 89 mm Hg) more often. In a backward stepwise Cox-regression analysis, age (per 1 year; relative risk [RR], 1.12), current smoking (RR, 3.21), BMI (per SD; RR, 1.39), high-normal diastolic BP (RR, 2.35), history of CHD (RR, 4.92), and gastric ulcer (RR, 2.21) remained significantly associated with incidence of stroke.
Conclusion— In subjects with normal BP, there are a number of potentially modifiable risk factors associated with an increased incidence of stroke. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/131847
- author
- Li, Cairu LU ; Engström, Gunnar LU ; Hedblad, Bo LU ; Berglund, Göran LU and Janzon, Lars LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- risk factors, stroke, blood pressure
- in
- Stroke: a journal of cerebral circulation
- volume
- 36
- issue
- 2
- pages
- 234 - 238
- publisher
- American Heart Association
- external identifiers
-
- wos:000226507600029
- pmid:15618439
- scopus:12844275885
- ISSN
- 1524-4628
- DOI
- 10.1161/01.STR.0000152328.66493.0a
- language
- English
- LU publication?
- yes
- id
- 6edac589-ed47-4664-863e-802832230fbb (old id 131847)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15618439&dopt=Abstract
- date added to LUP
- 2016-04-01 16:42:07
- date last changed
- 2025-04-04 15:15:47
@article{6edac589-ed47-4664-863e-802832230fbb,
abstract = {{Background and Purpose— Although stroke is strongly associated with hypertension, some individuals with normal blood pressure (BP) experience a stroke. This prospective study explored risk factors for stroke in subjects with normal BP.<br/><br>
<br/><br>
Methods— A total of 11 228 men and 17 174 women, 45 to 73 years old, were examined in a population-based cohort study. Normal BP was defined as BP <140/90 mm Hg and no treatment for hypertension. The incidence of stroke was followed over a mean period of 6 years.<br/><br>
<br/><br>
Results— In the cohort, 10 938 (38%) had normal BP. Of them, 56 patients experienced a first-ever stroke (12% of all stroke). Compared with subjects without stroke during follow-up, these stroke subjects were older, had lower education, were often smokers and alcohol nondrinkers, and had a history of coronary heart disease (CHD), gastric ulcer, or renal calculus. Subjects with stroke had a higher body mass index (BMI) and a high-normal BP (130 to 139/85 to 89 mm Hg) more often. In a backward stepwise Cox-regression analysis, age (per 1 year; relative risk [RR], 1.12), current smoking (RR, 3.21), BMI (per SD; RR, 1.39), high-normal diastolic BP (RR, 2.35), history of CHD (RR, 4.92), and gastric ulcer (RR, 2.21) remained significantly associated with incidence of stroke.<br/><br>
<br/><br>
Conclusion— In subjects with normal BP, there are a number of potentially modifiable risk factors associated with an increased incidence of stroke.}},
author = {{Li, Cairu and Engström, Gunnar and Hedblad, Bo and Berglund, Göran and Janzon, Lars}},
issn = {{1524-4628}},
keywords = {{risk factors; stroke; blood pressure}},
language = {{eng}},
number = {{2}},
pages = {{234--238}},
publisher = {{American Heart Association}},
series = {{Stroke: a journal of cerebral circulation}},
title = {{Risk Factors for Stroke in Subjects With Normal Blood Pressure. A Prospective Cohort Study.}},
url = {{http://dx.doi.org/10.1161/01.STR.0000152328.66493.0a}},
doi = {{10.1161/01.STR.0000152328.66493.0a}},
volume = {{36}},
year = {{2005}},
}