Postmenopausal extragenital choriocarcinoma. A case report and review of the literature
(1991) In European Journal of Gynaecological Oncology 12(5). p.8-395- Abstract
A case is presented of extragenital abdominal choriocarcinoma without uterine lesion in a postmenopausal woman. Nineteen years after her antecedent pregnancy, a legal abortion, and thirteen years after her menopause, the patient was admitted to the hospital because of intermittent abdominal pain. Explorative laparotomy revealed a large tumour mass in the greater omentum, mesosigmoideum, peritoneal implants and metastatic growth to the serosal lining of the uterus and the wall of the stomach. Cytoreductive surgery was performed. The histopathological report showed an extrauterine, nongonadal pure choriocarcinoma. Immunoperoxidase stain was strongly positive for hCG and a raised serum beta-hCG level preoperatively confirmed the diagnosis.... (More)
A case is presented of extragenital abdominal choriocarcinoma without uterine lesion in a postmenopausal woman. Nineteen years after her antecedent pregnancy, a legal abortion, and thirteen years after her menopause, the patient was admitted to the hospital because of intermittent abdominal pain. Explorative laparotomy revealed a large tumour mass in the greater omentum, mesosigmoideum, peritoneal implants and metastatic growth to the serosal lining of the uterus and the wall of the stomach. Cytoreductive surgery was performed. The histopathological report showed an extrauterine, nongonadal pure choriocarcinoma. Immunoperoxidase stain was strongly positive for hCG and a raised serum beta-hCG level preoperatively confirmed the diagnosis. A polychemotherapy regimen was administered. However, after six months the beta-hCG levels increased rapidly. Liver, lung and mediastinal metastases were diagnosed. The patient's condition rapidly deteriorated and she expired one month later. The post mortem examination showed a far advanced extragonadal pure choriocarcinoma without any obvious primary origin. The implications for a possible origin of extragonadal nongestational choriocarcinoma are briefly discussed.
(Less)
- author
- Brunner, J ; Högberg, T LU ; Malmström, H and Simonsen, E
- publishing date
- 1991
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Abdominal Neoplasms/blood, Choriocarcinoma/blood, Chorionic Gonadotropin/blood, Female, Humans, Menopause, Middle Aged, Neoplasms, Unknown Primary
- in
- European Journal of Gynaecological Oncology
- volume
- 12
- issue
- 5
- pages
- 4 pages
- publisher
- SOG Canada.
- external identifiers
-
- scopus:0025851369
- pmid:1915465
- ISSN
- 0392-2936
- language
- English
- LU publication?
- no
- id
- 6ee01a82-a3d6-4731-a24e-dda99c2b050e
- date added to LUP
- 2019-09-20 08:17:28
- date last changed
- 2024-01-01 20:58:50
@article{6ee01a82-a3d6-4731-a24e-dda99c2b050e,
abstract = {{<p>A case is presented of extragenital abdominal choriocarcinoma without uterine lesion in a postmenopausal woman. Nineteen years after her antecedent pregnancy, a legal abortion, and thirteen years after her menopause, the patient was admitted to the hospital because of intermittent abdominal pain. Explorative laparotomy revealed a large tumour mass in the greater omentum, mesosigmoideum, peritoneal implants and metastatic growth to the serosal lining of the uterus and the wall of the stomach. Cytoreductive surgery was performed. The histopathological report showed an extrauterine, nongonadal pure choriocarcinoma. Immunoperoxidase stain was strongly positive for hCG and a raised serum beta-hCG level preoperatively confirmed the diagnosis. A polychemotherapy regimen was administered. However, after six months the beta-hCG levels increased rapidly. Liver, lung and mediastinal metastases were diagnosed. The patient's condition rapidly deteriorated and she expired one month later. The post mortem examination showed a far advanced extragonadal pure choriocarcinoma without any obvious primary origin. The implications for a possible origin of extragonadal nongestational choriocarcinoma are briefly discussed.</p>}},
author = {{Brunner, J and Högberg, T and Malmström, H and Simonsen, E}},
issn = {{0392-2936}},
keywords = {{Abdominal Neoplasms/blood; Choriocarcinoma/blood; Chorionic Gonadotropin/blood; Female; Humans; Menopause; Middle Aged; Neoplasms, Unknown Primary}},
language = {{eng}},
number = {{5}},
pages = {{8--395}},
publisher = {{SOG Canada.}},
series = {{European Journal of Gynaecological Oncology}},
title = {{Postmenopausal extragenital choriocarcinoma. A case report and review of the literature}},
volume = {{12}},
year = {{1991}},
}