Resveratrol protects the mitochondria from vitrification injury in mouse 2-cell embryos
Gao, Zhen ; Yao, Ge ; Zhang, Hui ; Liu, Haokun ; Yang, Zhenshan LU
; Liu, Chen
; Li, Wei
; Zhao, Xiaoe
; wei, Qiang
and Ma, Baohua
(2020)
In Cryobiology
95.
p.123-129
- Abstract
Mitochondria play a key role in embryo development by providing energy. However, vitrification often causes mitochondrion damage of embryo, which further impairs embryo development. Therefore, the efficiency of embryo development after vitrification could be improved by protecting mitochondrial function from vitrification injury. The purpose of this study was to investigate the effects of resveratrol on mitochondrial damage after vitrification. The results showed that vitrification induced the abnormal mitochondrial distribution and damage mitochondrial function of mouse 2-cell embryos. However, co-culturing with resveratrol for 2 h could repair the abnormal mitochondrial distribution and mitochondrial dysfunction of embryos after... (More)
Mitochondria play a key role in embryo development by providing energy. However, vitrification often causes mitochondrion damage of embryo, which further impairs embryo development. Therefore, the efficiency of embryo development after vitrification could be improved by protecting mitochondrial function from vitrification injury. The purpose of this study was to investigate the effects of resveratrol on mitochondrial damage after vitrification. The results showed that vitrification induced the abnormal mitochondrial distribution and damage mitochondrial function of mouse 2-cell embryos. However, co-culturing with resveratrol for 2 h could repair the abnormal mitochondrial distribution and mitochondrial dysfunction of embryos after vitrification. More than anything, the subsequent development ability of vitrified-thawed 2-cell embryos was significantly higher than that with no resveratrol treatment. In conclusion, resveratrol could protect the mitochondrial from injury caused by vitrification.
(Less)
- author
- Gao, Zhen
; Yao, Ge
; Zhang, Hui
; Liu, Haokun
; Yang, Zhenshan
LU
; Liu, Chen
; Li, Wei
; Zhao, Xiaoe
; wei, Qiang
and Ma, Baohua
- publishing date
- 2020-08
- type
- Contribution to journal
- publication status
- published
- keywords
- 2-Cell embryo, Mitochondria, Mouse, Resveratrol, Vitrification
- in
- Cryobiology
- volume
- 95
- pages
- 123 - 129
- publisher
- Elsevier
- external identifiers
-
- pmid:32464144
- scopus:85085625336
- ISSN
- 0011-2240
- DOI
- 10.1016/j.cryobiol.2020.05.007
- language
- English
- LU publication?
- no
- additional info
- Funding Information: The authors would like to thank other members of the Ma lab for their help in collecting embryos from mice and the support of Life Science Research Core Services (LSRCS), Northwest A&F University for skillful technical assistance. This study was supported by the Strategic Priority Research Program of Chinese Academy of Sciences (XDA 04020222 ) and Key Research and Development Program of Shaanxi (Program No. 2018NY-023 ). Funding Information: The authors would like to thank other members of the Ma lab for their help in collecting embryos from mice and the support of Life Science Research Core Services (LSRCS), Northwest A&F University for skillful technical assistance. This study was supported by the Strategic Priority Research Program of Chinese Academy of Sciences (XDA 04020222) and Key Research and Development Program of Shaanxi (Program No. 2018NY-023). Publisher Copyright: © 2020 Elsevier Inc.
- id
- 6f2efcde-a06d-466c-8027-d28a030bdb2a
- date added to LUP
- 2024-02-28 15:00:16
- date last changed
- 2024-04-27 18:39:15
@article{6f2efcde-a06d-466c-8027-d28a030bdb2a,
abstract = {{<p>Mitochondria play a key role in embryo development by providing energy. However, vitrification often causes mitochondrion damage of embryo, which further impairs embryo development. Therefore, the efficiency of embryo development after vitrification could be improved by protecting mitochondrial function from vitrification injury. The purpose of this study was to investigate the effects of resveratrol on mitochondrial damage after vitrification. The results showed that vitrification induced the abnormal mitochondrial distribution and damage mitochondrial function of mouse 2-cell embryos. However, co-culturing with resveratrol for 2 h could repair the abnormal mitochondrial distribution and mitochondrial dysfunction of embryos after vitrification. More than anything, the subsequent development ability of vitrified-thawed 2-cell embryos was significantly higher than that with no resveratrol treatment. In conclusion, resveratrol could protect the mitochondrial from injury caused by vitrification.</p>}},
author = {{Gao, Zhen and Yao, Ge and Zhang, Hui and Liu, Haokun and Yang, Zhenshan and Liu, Chen and Li, Wei and Zhao, Xiaoe and wei, Qiang and Ma, Baohua}},
issn = {{0011-2240}},
keywords = {{2-Cell embryo; Mitochondria; Mouse; Resveratrol; Vitrification}},
language = {{eng}},
pages = {{123--129}},
publisher = {{Elsevier}},
series = {{Cryobiology}},
title = {{Resveratrol protects the mitochondria from vitrification injury in mouse 2-cell embryos}},
url = {{http://dx.doi.org/10.1016/j.cryobiol.2020.05.007}},
doi = {{10.1016/j.cryobiol.2020.05.007}},
volume = {{95}},
year = {{2020}},
}