Prohibitins : mitochondrial partners in development and stress response
(2010) In Trends in Plant Science 15(5). p.82-275- Abstract
Twelve years after their discovery in plants, prohibitins (PHBs) have retained their status as some of the most enigmatic mitochondrial proteins. Although the original hypothesis that PHBs act as negative cell cycle regulators has lost its impetus in plants, the essential molecular function(s) PHB complexes perform in the inner mitochondrial membrane are now beginning to be understood. We review the current state of knowledge to propose a unifying model that positions the PHB complex as a universal protein scaffold for key mitochondrial processes, including protein processing, respiratory chain function and mitochondrial DNA organization. Furthermore, recent findings indicate that PHBs play an active role in stress tolerance and are... (More)
Twelve years after their discovery in plants, prohibitins (PHBs) have retained their status as some of the most enigmatic mitochondrial proteins. Although the original hypothesis that PHBs act as negative cell cycle regulators has lost its impetus in plants, the essential molecular function(s) PHB complexes perform in the inner mitochondrial membrane are now beginning to be understood. We review the current state of knowledge to propose a unifying model that positions the PHB complex as a universal protein scaffold for key mitochondrial processes, including protein processing, respiratory chain function and mitochondrial DNA organization. Furthermore, recent findings indicate that PHBs play an active role in stress tolerance and are involved in triggering retrograde signals in response to stress and mitochondrial dysfunction.
(Less)
- author
- Van Aken, Olivier LU ; Whelan, James and Van Breusegem, Frank
- publishing date
- 2010-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Humans, Mitochondria, Phylogeny, Plant Development, Plants, Repressor Proteins, Signal Transduction, Stress, Physiological
- in
- Trends in Plant Science
- volume
- 15
- issue
- 5
- pages
- 8 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:77953284896
- pmid:20226718
- ISSN
- 1360-1385
- DOI
- 10.1016/j.tplants.2010.02.002
- language
- English
- LU publication?
- no
- id
- 6f9d5699-95f1-42ec-b4b7-8b8cf2d19b99
- date added to LUP
- 2017-05-09 10:08:22
- date last changed
- 2024-04-14 10:14:50
@article{6f9d5699-95f1-42ec-b4b7-8b8cf2d19b99,
abstract = {{<p>Twelve years after their discovery in plants, prohibitins (PHBs) have retained their status as some of the most enigmatic mitochondrial proteins. Although the original hypothesis that PHBs act as negative cell cycle regulators has lost its impetus in plants, the essential molecular function(s) PHB complexes perform in the inner mitochondrial membrane are now beginning to be understood. We review the current state of knowledge to propose a unifying model that positions the PHB complex as a universal protein scaffold for key mitochondrial processes, including protein processing, respiratory chain function and mitochondrial DNA organization. Furthermore, recent findings indicate that PHBs play an active role in stress tolerance and are involved in triggering retrograde signals in response to stress and mitochondrial dysfunction.</p>}},
author = {{Van Aken, Olivier and Whelan, James and Van Breusegem, Frank}},
issn = {{1360-1385}},
keywords = {{Animals; Humans; Mitochondria; Phylogeny; Plant Development; Plants; Repressor Proteins; Signal Transduction; Stress, Physiological}},
language = {{eng}},
number = {{5}},
pages = {{82--275}},
publisher = {{Elsevier}},
series = {{Trends in Plant Science}},
title = {{Prohibitins : mitochondrial partners in development and stress response}},
url = {{http://dx.doi.org/10.1016/j.tplants.2010.02.002}},
doi = {{10.1016/j.tplants.2010.02.002}},
volume = {{15}},
year = {{2010}},
}