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Prohibitins : mitochondrial partners in development and stress response

Van Aken, Olivier LU ; Whelan, James and Van Breusegem, Frank (2010) In Trends in Plant Science 15(5). p.82-275
Abstract

Twelve years after their discovery in plants, prohibitins (PHBs) have retained their status as some of the most enigmatic mitochondrial proteins. Although the original hypothesis that PHBs act as negative cell cycle regulators has lost its impetus in plants, the essential molecular function(s) PHB complexes perform in the inner mitochondrial membrane are now beginning to be understood. We review the current state of knowledge to propose a unifying model that positions the PHB complex as a universal protein scaffold for key mitochondrial processes, including protein processing, respiratory chain function and mitochondrial DNA organization. Furthermore, recent findings indicate that PHBs play an active role in stress tolerance and are... (More)

Twelve years after their discovery in plants, prohibitins (PHBs) have retained their status as some of the most enigmatic mitochondrial proteins. Although the original hypothesis that PHBs act as negative cell cycle regulators has lost its impetus in plants, the essential molecular function(s) PHB complexes perform in the inner mitochondrial membrane are now beginning to be understood. We review the current state of knowledge to propose a unifying model that positions the PHB complex as a universal protein scaffold for key mitochondrial processes, including protein processing, respiratory chain function and mitochondrial DNA organization. Furthermore, recent findings indicate that PHBs play an active role in stress tolerance and are involved in triggering retrograde signals in response to stress and mitochondrial dysfunction.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Humans, Mitochondria, Phylogeny, Plant Development, Plants, Repressor Proteins, Signal Transduction, Stress, Physiological
in
Trends in Plant Science
volume
15
issue
5
pages
8 pages
publisher
Elsevier
external identifiers
  • scopus:77953284896
ISSN
1360-1385
DOI
10.1016/j.tplants.2010.02.002
language
English
LU publication?
no
id
6f9d5699-95f1-42ec-b4b7-8b8cf2d19b99
date added to LUP
2017-05-09 10:08:22
date last changed
2018-05-29 11:44:58
@article{6f9d5699-95f1-42ec-b4b7-8b8cf2d19b99,
  abstract     = {<p>Twelve years after their discovery in plants, prohibitins (PHBs) have retained their status as some of the most enigmatic mitochondrial proteins. Although the original hypothesis that PHBs act as negative cell cycle regulators has lost its impetus in plants, the essential molecular function(s) PHB complexes perform in the inner mitochondrial membrane are now beginning to be understood. We review the current state of knowledge to propose a unifying model that positions the PHB complex as a universal protein scaffold for key mitochondrial processes, including protein processing, respiratory chain function and mitochondrial DNA organization. Furthermore, recent findings indicate that PHBs play an active role in stress tolerance and are involved in triggering retrograde signals in response to stress and mitochondrial dysfunction.</p>},
  author       = {Van Aken, Olivier and Whelan, James and Van Breusegem, Frank},
  issn         = {1360-1385},
  keyword      = {Animals,Humans,Mitochondria,Phylogeny,Plant Development,Plants,Repressor Proteins,Signal Transduction,Stress, Physiological},
  language     = {eng},
  number       = {5},
  pages        = {82--275},
  publisher    = {Elsevier},
  series       = {Trends in Plant Science},
  title        = {Prohibitins : mitochondrial partners in development and stress response},
  url          = {http://dx.doi.org/10.1016/j.tplants.2010.02.002},
  volume       = {15},
  year         = {2010},
}