Sex differences in associations between APOE ε2 and longitudinal cognitive decline
(2023) In Alzheimer's and Dementia 19(10). p.4651-4661- Abstract
INTRODUCTION: We examined whether sex modifies the association between APOE ε2 and cognitive decline in two independent samples. METHODS: We used observational data from cognitively unimpaired non-Hispanic White (NHW) and non-Hispanic Black (NHB) adults. Linear mixed models examined interactive associations of APOE genotype (ε2 or ε4 carrier vs. ε3/ε3) and sex on cognitive decline in NHW and NHB participants separately. RESULTS: In both Sample 1 (N = 9766) and Sample 2 (N = 915), sex modified the association between APOE ε2 and cognitive decline in NHW participants. Specifically, relative to APOE ε3/ε3, APOE ε2 protected against cognitive decline in men but not women. Among APOE ε2 carriers, men had slower decline than women. Among APOE... (More)
INTRODUCTION: We examined whether sex modifies the association between APOE ε2 and cognitive decline in two independent samples. METHODS: We used observational data from cognitively unimpaired non-Hispanic White (NHW) and non-Hispanic Black (NHB) adults. Linear mixed models examined interactive associations of APOE genotype (ε2 or ε4 carrier vs. ε3/ε3) and sex on cognitive decline in NHW and NHB participants separately. RESULTS: In both Sample 1 (N = 9766) and Sample 2 (N = 915), sex modified the association between APOE ε2 and cognitive decline in NHW participants. Specifically, relative to APOE ε3/ε3, APOE ε2 protected against cognitive decline in men but not women. Among APOE ε2 carriers, men had slower decline than women. Among APOE ε3/ε3 carriers, cognitive trajectories did not differ between sexes. There were no sex-specific associations of APOE ε2 with cognition in NHB participants (N = 2010). DISCUSSION: In NHW adults, APOE ε2 may protect men but not women against cognitive decline. Highlights: We studied sex-specific apolipoprotein E (APOE) ε2 effects on cognitive decline. In non-Hispanic White (NHW) adults, APOE ε2 selectively protects men against decline. Among men, APOE ε2 was more protective than APOE ε3/ε3. In women, APOE ε2 was no more protective than APOE ε3/ε3. Among APOE ε2 carriers, men had slower decline than women. There were no sex-specific APOE ε2 effects in non-Hispanic Black (NHB) adults.
(Less)
- author
- author collaboration
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alzheimer's disease, APOE, cognitive decline, race/ethnicity, sex differences
- in
- Alzheimer's and Dementia
- volume
- 19
- issue
- 10
- pages
- 4651 - 4661
- publisher
- Wiley
- external identifiers
-
- pmid:36994910
- scopus:85152453322
- ISSN
- 1552-5260
- DOI
- 10.1002/alz.13036
- language
- English
- LU publication?
- yes
- id
- 6fbb2a47-e96e-4aa3-b61f-f330c7d04464
- date added to LUP
- 2023-07-20 13:32:14
- date last changed
- 2024-04-19 23:51:23
@article{6fbb2a47-e96e-4aa3-b61f-f330c7d04464,
abstract = {{<p>INTRODUCTION: We examined whether sex modifies the association between APOE ε2 and cognitive decline in two independent samples. METHODS: We used observational data from cognitively unimpaired non-Hispanic White (NHW) and non-Hispanic Black (NHB) adults. Linear mixed models examined interactive associations of APOE genotype (ε2 or ε4 carrier vs. ε3/ε3) and sex on cognitive decline in NHW and NHB participants separately. RESULTS: In both Sample 1 (N = 9766) and Sample 2 (N = 915), sex modified the association between APOE ε2 and cognitive decline in NHW participants. Specifically, relative to APOE ε3/ε3, APOE ε2 protected against cognitive decline in men but not women. Among APOE ε2 carriers, men had slower decline than women. Among APOE ε3/ε3 carriers, cognitive trajectories did not differ between sexes. There were no sex-specific associations of APOE ε2 with cognition in NHB participants (N = 2010). DISCUSSION: In NHW adults, APOE ε2 may protect men but not women against cognitive decline. Highlights: We studied sex-specific apolipoprotein E (APOE) ε2 effects on cognitive decline. In non-Hispanic White (NHW) adults, APOE ε2 selectively protects men against decline. Among men, APOE ε2 was more protective than APOE ε3/ε3. In women, APOE ε2 was no more protective than APOE ε3/ε3. Among APOE ε2 carriers, men had slower decline than women. There were no sex-specific APOE ε2 effects in non-Hispanic Black (NHB) adults.</p>}},
author = {{Wood, Madeline E. and Xiong, Lisa Y. and Wong, Yuen Yan and Buckley, Rachel F. and Swardfager, Walter and Masellis, Mario and Lim, Andrew S.P. and Nichols, Emma and Joie, Renaud La and Casaletto, Kaitlin B. and Kumar, Raj G. and Dams-O'Connor, Kristen and Palta, Priya and George, Kristen M. and Satizabal, Claudia L. and Barnes, Lisa L. and Schneider, Julie A. and Binet, Alexa Pichette and Villeneuve, Sylvia and Pa, Judy and Brickman, Adam M. and Black, Sandra E. and Rabin, Jennifer S.}},
issn = {{1552-5260}},
keywords = {{Alzheimer's disease; APOE; cognitive decline; race/ethnicity; sex differences}},
language = {{eng}},
number = {{10}},
pages = {{4651--4661}},
publisher = {{Wiley}},
series = {{Alzheimer's and Dementia}},
title = {{Sex differences in associations between APOE ε2 and longitudinal cognitive decline}},
url = {{http://dx.doi.org/10.1002/alz.13036}},
doi = {{10.1002/alz.13036}},
volume = {{19}},
year = {{2023}},
}