Differential expression of CK20, β-catenin, and MUC2/5AC/6 in Lynch syndrome and familial colorectal cancer type X
(2017) In BMC Clinical Pathology 17(1).- Abstract
Background: Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The purpose of this study is to characterize their immunoprofile of markers other than MMR proteins. Methods: We compared the expression patterns of cytokeratins (CK7 and CK20), mucins (MUC2/5 AC/6), CDX2 and β-catenin in Lynch syndrome and FCCTX. Results: Differences were identified for CK20 and nuclear β-catenin, which were significantly more often expressed in FCCTX than in Lynch syndrome (p < 0.001), whereas MUC2, MUC5AC and MUC6 were overexpressed in Lynch syndrome tumors compared with FCCTX tumors (p = 0.001, <... (More)
Background: Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The purpose of this study is to characterize their immunoprofile of markers other than MMR proteins. Methods: We compared the expression patterns of cytokeratins (CK7 and CK20), mucins (MUC2/5 AC/6), CDX2 and β-catenin in Lynch syndrome and FCCTX. Results: Differences were identified for CK20 and nuclear β-catenin, which were significantly more often expressed in FCCTX than in Lynch syndrome (p < 0.001), whereas MUC2, MUC5AC and MUC6 were overexpressed in Lynch syndrome tumors compared with FCCTX tumors (p = 0.001, < 0.01, and < 0.001, respectively). We observed no differences in the expression patterns of CK7 and CDX2. Conclusions: In summary, we identified significant differences in the immunoprofiles of colorectal cancers linked to FCCTX and Lynch syndrome with a more sporadic-like profile in the former group and a more distinct profile with frequent MUC6 positivity in the latter group.
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- author
- Haraldsson, Stefan ; Klarskov, Louise ; Nilbert, Mef LU ; Bernstein, Inge ; Bonde, Jesper and Holck, Susanne
- organization
- publishing date
- 2017-08-17
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Fcctx, Hereditary non-polyposis colorectal cancer, Immunohistochemical profile, Lynch syndrome
- in
- BMC Clinical Pathology
- volume
- 17
- issue
- 1
- article number
- 11
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85027515565
- pmid:28824332
- pmid:28824332
- wos:000407822700001
- ISSN
- 1472-6890
- DOI
- 10.1186/s12907-017-0052-1
- language
- English
- LU publication?
- yes
- id
- 6fd1a333-1282-4ad7-b3e7-9e7e4e351886
- date added to LUP
- 2017-09-04 12:02:56
- date last changed
- 2024-03-17 20:18:24
@article{6fd1a333-1282-4ad7-b3e7-9e7e4e351886, abstract = {{<p>Background: Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The purpose of this study is to characterize their immunoprofile of markers other than MMR proteins. Methods: We compared the expression patterns of cytokeratins (CK7 and CK20), mucins (MUC2/5 AC/6), CDX2 and β-catenin in Lynch syndrome and FCCTX. Results: Differences were identified for CK20 and nuclear β-catenin, which were significantly more often expressed in FCCTX than in Lynch syndrome (p < 0.001), whereas MUC2, MUC5AC and MUC6 were overexpressed in Lynch syndrome tumors compared with FCCTX tumors (p = 0.001, < 0.01, and < 0.001, respectively). We observed no differences in the expression patterns of CK7 and CDX2. Conclusions: In summary, we identified significant differences in the immunoprofiles of colorectal cancers linked to FCCTX and Lynch syndrome with a more sporadic-like profile in the former group and a more distinct profile with frequent MUC6 positivity in the latter group.</p>}}, author = {{Haraldsson, Stefan and Klarskov, Louise and Nilbert, Mef and Bernstein, Inge and Bonde, Jesper and Holck, Susanne}}, issn = {{1472-6890}}, keywords = {{Fcctx; Hereditary non-polyposis colorectal cancer; Immunohistochemical profile; Lynch syndrome}}, language = {{eng}}, month = {{08}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{BMC Clinical Pathology}}, title = {{Differential expression of CK20, β-catenin, and MUC2/5AC/6 in Lynch syndrome and familial colorectal cancer type X}}, url = {{http://dx.doi.org/10.1186/s12907-017-0052-1}}, doi = {{10.1186/s12907-017-0052-1}}, volume = {{17}}, year = {{2017}}, }