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Differential expression of CK20, β-catenin, and MUC2/5AC/6 in Lynch syndrome and familial colorectal cancer type X

Haraldsson, Stefan; Klarskov, Louise; Nilbert, Mef LU ; Bernstein, Inge; Bonde, Jesper and Holck, Susanne (2017) In BMC Clinical Pathology 17(1).
Abstract

Background: Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The purpose of this study is to characterize their immunoprofile of markers other than MMR proteins. Methods: We compared the expression patterns of cytokeratins (CK7 and CK20), mucins (MUC2/5 AC/6), CDX2 and β-catenin in Lynch syndrome and FCCTX. Results: Differences were identified for CK20 and nuclear β-catenin, which were significantly more often expressed in FCCTX than in Lynch syndrome (p < 0.001), whereas MUC2, MUC5AC and MUC6 were overexpressed in Lynch syndrome tumors compared with FCCTX tumors (p = 0.001, <... (More)

Background: Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The purpose of this study is to characterize their immunoprofile of markers other than MMR proteins. Methods: We compared the expression patterns of cytokeratins (CK7 and CK20), mucins (MUC2/5 AC/6), CDX2 and β-catenin in Lynch syndrome and FCCTX. Results: Differences were identified for CK20 and nuclear β-catenin, which were significantly more often expressed in FCCTX than in Lynch syndrome (p < 0.001), whereas MUC2, MUC5AC and MUC6 were overexpressed in Lynch syndrome tumors compared with FCCTX tumors (p = 0.001, < 0.01, and < 0.001, respectively). We observed no differences in the expression patterns of CK7 and CDX2. Conclusions: In summary, we identified significant differences in the immunoprofiles of colorectal cancers linked to FCCTX and Lynch syndrome with a more sporadic-like profile in the former group and a more distinct profile with frequent MUC6 positivity in the latter group.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Fcctx, Hereditary non-polyposis colorectal cancer, Immunohistochemical profile, Lynch syndrome
in
BMC Clinical Pathology
volume
17
issue
1
publisher
BioMed Central
external identifiers
  • scopus:85027515565
  • pmid: 28824332
  • wos:000407822700001
ISSN
1472-6890
DOI
10.1186/s12907-017-0052-1
language
English
LU publication?
yes
id
6fd1a333-1282-4ad7-b3e7-9e7e4e351886
date added to LUP
2017-09-04 12:02:56
date last changed
2017-09-18 11:38:49
@article{6fd1a333-1282-4ad7-b3e7-9e7e4e351886,
  abstract     = {<p>Background: Hereditary non-polyposis colorectal cancer comprises Lynch syndrome and familial colorectal cancer type X (FCCTX). Differences in genetics, demographics and histopathology have been extensively studied. The purpose of this study is to characterize their immunoprofile of markers other than MMR proteins. Methods: We compared the expression patterns of cytokeratins (CK7 and CK20), mucins (MUC2/5 AC/6), CDX2 and β-catenin in Lynch syndrome and FCCTX. Results: Differences were identified for CK20 and nuclear β-catenin, which were significantly more often expressed in FCCTX than in Lynch syndrome (p &lt; 0.001), whereas MUC2, MUC5AC and MUC6 were overexpressed in Lynch syndrome tumors compared with FCCTX tumors (p = 0.001, &lt; 0.01, and &lt; 0.001, respectively). We observed no differences in the expression patterns of CK7 and CDX2. Conclusions: In summary, we identified significant differences in the immunoprofiles of colorectal cancers linked to FCCTX and Lynch syndrome with a more sporadic-like profile in the former group and a more distinct profile with frequent MUC6 positivity in the latter group.</p>},
  articleno    = {11},
  author       = {Haraldsson, Stefan and Klarskov, Louise and Nilbert, Mef and Bernstein, Inge and Bonde, Jesper and Holck, Susanne},
  issn         = {1472-6890},
  keyword      = {Fcctx,Hereditary non-polyposis colorectal cancer,Immunohistochemical profile,Lynch syndrome},
  language     = {eng},
  month        = {08},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {BMC Clinical Pathology},
  title        = {Differential expression of CK20, β-catenin, and MUC2/5AC/6 in Lynch syndrome and familial colorectal cancer type X},
  url          = {http://dx.doi.org/10.1186/s12907-017-0052-1},
  volume       = {17},
  year         = {2017},
}