Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Reduced wound healing capacity in alcohol abusers - reversibility after withdrawal

Tønnesen, Hanne LU ; Pedersen, Susanne ; Lavrsen, Michael ; Tuxøe, Jon Ivar and Frøkjær Thomsen, Christian (2012) In Clinical Health Promotion 2(3). p.89-92
Abstract
BackgroundAlcohol abusers have increased risk of wound complications following surgical procedures, however the development of complications is reduced after preoperative withdrawal from alcohol. Therefore the aim of the study was to evaluate wound healing at alcohol abuse and after withdrawal. MethodsIn total 16 alcohol abusers were included and tested. Nine abusers were able to abstain from alcohol and were retested after 8 weeks of abstinence. No patients had clinical or biochemical signs of hepatic or renal disease. Collagen and total protein accumulation in wound granulation tissue were evaluated from the deposited amount of hydroxyproline and proline in two subcutaneously implanted polytetrafluoroetylene tubes.ResultsThe amount of... (More)
BackgroundAlcohol abusers have increased risk of wound complications following surgical procedures, however the development of complications is reduced after preoperative withdrawal from alcohol. Therefore the aim of the study was to evaluate wound healing at alcohol abuse and after withdrawal. MethodsIn total 16 alcohol abusers were included and tested. Nine abusers were able to abstain from alcohol and were retested after 8 weeks of abstinence. No patients had clinical or biochemical signs of hepatic or renal disease. Collagen and total protein accumulation in wound granulation tissue were evaluated from the deposited amount of hydroxyproline and proline in two subcutaneously implanted polytetrafluoroetylene tubes.ResultsThe amount of proline and total protein increased significantly after 8 weeks of abstinence, median 81.3 nmoI/mm (inter-quartile range: 77.1-92.9) versus 69.3 nmol/mm (68.5-76.3), p < 0.05, and 632 nmol/mm (505-1,127) versus 571 nmol/mm (544-831), p < 0.05, respectively. There was no significant change of hydroxyproline. ConclusionThis study showed a change in the protein level of the wound healing process among alcohol abusers, which seemed reversible after withdrawal. (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Health Promotion
volume
2
issue
3
pages
4 pages
publisher
Clinical Health Promotion Society (CHPS)
ISSN
2226-5864
language
English
LU publication?
yes
id
6ff9870d-ce09-4540-a414-8fec648fbf7c
alternative location
https://docs.wixstatic.com/ugd/7b6489_8c9b38394c034e31abbaebcb601403bf.pdf
date added to LUP
2018-12-06 15:38:09
date last changed
2018-12-11 16:04:48
@article{6ff9870d-ce09-4540-a414-8fec648fbf7c,
  abstract     = {{BackgroundAlcohol abusers have increased risk of wound complications following surgical procedures, however the development of complications is reduced after preoperative withdrawal from alcohol. Therefore the aim of the study was to evaluate wound healing at alcohol abuse and after withdrawal. MethodsIn total 16 alcohol abusers were included and tested. Nine abusers were able to abstain from alcohol and were retested after 8 weeks of abstinence. No patients had clinical or biochemical signs of hepatic or renal disease. Collagen and total protein accumulation in wound granulation tissue were evaluated from the deposited amount of hydroxyproline and proline in two subcutaneously implanted polytetrafluoroetylene tubes.ResultsThe amount of proline and total protein increased significantly after 8 weeks of abstinence, median 81.3 nmoI/mm (inter-quartile range: 77.1-92.9) versus 69.3 nmol/mm (68.5-76.3), p &lt; 0.05, and 632 nmol/mm (505-1,127) versus 571 nmol/mm (544-831), p &lt; 0.05, respectively. There was no significant change of hydroxyproline. ConclusionThis study showed a change in the protein level of the wound healing process among alcohol abusers, which seemed reversible after withdrawal.}},
  author       = {{Tønnesen, Hanne and Pedersen, Susanne and Lavrsen, Michael and Tuxøe, Jon Ivar and Frøkjær Thomsen, Christian}},
  issn         = {{2226-5864}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{89--92}},
  publisher    = {{Clinical Health Promotion Society (CHPS)}},
  series       = {{Clinical Health Promotion}},
  title        = {{Reduced wound healing capacity in alcohol abusers - reversibility after withdrawal}},
  url          = {{https://docs.wixstatic.com/ugd/7b6489_8c9b38394c034e31abbaebcb601403bf.pdf}},
  volume       = {{2}},
  year         = {{2012}},
}