Translational Mini-Review Series on B cell subsets in disease. Reconstitution after haematopoietic stem cell transplantation - revelation of B cell developmental pathways and lineage phenotypes
(2012) In Clinical and Experimental Immunology 167(1). p.15-25- Abstract
Haematopoietic stem cell transplantation (HSCT) is an immunological treatment that has been used for more than 40 years to cure a variety of diseases. The procedure is associated with serious side effects, due to the severe impairment of the immune system induced by the treatment. After a conditioning regimen with high-dose chemotherapy, sometimes in combination with total body irradiation, haematopoietic stem cells are transferred from a donor, allowing a donor-derived blood system to form. Here, we discuss the current knowledge of humoral problems and B cell development after HSCT, and relate these to the current understanding of human peripheral B cell development. We describe how these studies have aided the identification of... (More)
Haematopoietic stem cell transplantation (HSCT) is an immunological treatment that has been used for more than 40 years to cure a variety of diseases. The procedure is associated with serious side effects, due to the severe impairment of the immune system induced by the treatment. After a conditioning regimen with high-dose chemotherapy, sometimes in combination with total body irradiation, haematopoietic stem cells are transferred from a donor, allowing a donor-derived blood system to form. Here, we discuss the current knowledge of humoral problems and B cell development after HSCT, and relate these to the current understanding of human peripheral B cell development. We describe how these studies have aided the identification of subsets of transitional B cells and also a robust memory B cell phenotype.
(Less)
- author
- Bemark, M.
LU
; Holmqvist, J. ; Abrahamsson, J. and Mellgren, K.
- publishing date
- 2012-01
- type
- Contribution to journal
- publication status
- published
- keywords
- B cell, Haematopoietic stem cell transplantation, Lymphocyte development
- in
- Clinical and Experimental Immunology
- volume
- 167
- issue
- 1
- pages
- 15 - 25
- publisher
- British Society for Immunology
- external identifiers
-
- scopus:82655184677
- pmid:22132880
- ISSN
- 0009-9104
- DOI
- 10.1111/j.1365-2249.2011.04469.x
- language
- English
- LU publication?
- no
- id
- 70042040-b4a6-4e0b-854a-a616a3910063
- date added to LUP
- 2023-12-06 16:52:11
- date last changed
- 2024-01-04 15:16:03
@article{70042040-b4a6-4e0b-854a-a616a3910063, abstract = {{<p>Haematopoietic stem cell transplantation (HSCT) is an immunological treatment that has been used for more than 40 years to cure a variety of diseases. The procedure is associated with serious side effects, due to the severe impairment of the immune system induced by the treatment. After a conditioning regimen with high-dose chemotherapy, sometimes in combination with total body irradiation, haematopoietic stem cells are transferred from a donor, allowing a donor-derived blood system to form. Here, we discuss the current knowledge of humoral problems and B cell development after HSCT, and relate these to the current understanding of human peripheral B cell development. We describe how these studies have aided the identification of subsets of transitional B cells and also a robust memory B cell phenotype.</p>}}, author = {{Bemark, M. and Holmqvist, J. and Abrahamsson, J. and Mellgren, K.}}, issn = {{0009-9104}}, keywords = {{B cell; Haematopoietic stem cell transplantation; Lymphocyte development}}, language = {{eng}}, number = {{1}}, pages = {{15--25}}, publisher = {{British Society for Immunology}}, series = {{Clinical and Experimental Immunology}}, title = {{Translational Mini-Review Series on B cell subsets in disease. Reconstitution after haematopoietic stem cell transplantation - revelation of B cell developmental pathways and lineage phenotypes}}, url = {{http://dx.doi.org/10.1111/j.1365-2249.2011.04469.x}}, doi = {{10.1111/j.1365-2249.2011.04469.x}}, volume = {{167}}, year = {{2012}}, }