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Translational Mini-Review Series on B cell subsets in disease. Reconstitution after haematopoietic stem cell transplantation - revelation of B cell developmental pathways and lineage phenotypes

Bemark, M. LU orcid ; Holmqvist, J. ; Abrahamsson, J. and Mellgren, K. (2012) In Clinical and Experimental Immunology 167(1). p.15-25
Abstract

Haematopoietic stem cell transplantation (HSCT) is an immunological treatment that has been used for more than 40 years to cure a variety of diseases. The procedure is associated with serious side effects, due to the severe impairment of the immune system induced by the treatment. After a conditioning regimen with high-dose chemotherapy, sometimes in combination with total body irradiation, haematopoietic stem cells are transferred from a donor, allowing a donor-derived blood system to form. Here, we discuss the current knowledge of humoral problems and B cell development after HSCT, and relate these to the current understanding of human peripheral B cell development. We describe how these studies have aided the identification of... (More)

Haematopoietic stem cell transplantation (HSCT) is an immunological treatment that has been used for more than 40 years to cure a variety of diseases. The procedure is associated with serious side effects, due to the severe impairment of the immune system induced by the treatment. After a conditioning regimen with high-dose chemotherapy, sometimes in combination with total body irradiation, haematopoietic stem cells are transferred from a donor, allowing a donor-derived blood system to form. Here, we discuss the current knowledge of humoral problems and B cell development after HSCT, and relate these to the current understanding of human peripheral B cell development. We describe how these studies have aided the identification of subsets of transitional B cells and also a robust memory B cell phenotype.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
B cell, Haematopoietic stem cell transplantation, Lymphocyte development
in
Clinical and Experimental Immunology
volume
167
issue
1
pages
15 - 25
publisher
British Society for Immunology
external identifiers
  • scopus:82655184677
  • pmid:22132880
ISSN
0009-9104
DOI
10.1111/j.1365-2249.2011.04469.x
language
English
LU publication?
no
id
70042040-b4a6-4e0b-854a-a616a3910063
date added to LUP
2023-12-06 16:52:11
date last changed
2024-01-04 15:16:03
@article{70042040-b4a6-4e0b-854a-a616a3910063,
  abstract     = {{<p>Haematopoietic stem cell transplantation (HSCT) is an immunological treatment that has been used for more than 40 years to cure a variety of diseases. The procedure is associated with serious side effects, due to the severe impairment of the immune system induced by the treatment. After a conditioning regimen with high-dose chemotherapy, sometimes in combination with total body irradiation, haematopoietic stem cells are transferred from a donor, allowing a donor-derived blood system to form. Here, we discuss the current knowledge of humoral problems and B cell development after HSCT, and relate these to the current understanding of human peripheral B cell development. We describe how these studies have aided the identification of subsets of transitional B cells and also a robust memory B cell phenotype.</p>}},
  author       = {{Bemark, M. and Holmqvist, J. and Abrahamsson, J. and Mellgren, K.}},
  issn         = {{0009-9104}},
  keywords     = {{B cell; Haematopoietic stem cell transplantation; Lymphocyte development}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{15--25}},
  publisher    = {{British Society for Immunology}},
  series       = {{Clinical and Experimental Immunology}},
  title        = {{Translational Mini-Review Series on B cell subsets in disease. Reconstitution after haematopoietic stem cell transplantation - revelation of B cell developmental pathways and lineage phenotypes}},
  url          = {{http://dx.doi.org/10.1111/j.1365-2249.2011.04469.x}},
  doi          = {{10.1111/j.1365-2249.2011.04469.x}},
  volume       = {{167}},
  year         = {{2012}},
}