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Depression is associated with poor prognosis in patients with chronic obstructive pulmonary disease - a systematic review

Salte, Kim; Titlestad, Ingrid and Halling, Anders LU (2015) In Danish Medical Journal 62(10). p.5137-5137
Abstract

INTRODUCTION: Patients with depression have significantly increased mortality from somatic disease. The purpose of this article was to review studies that investigate if there is a prognostic association with depression as co-morbidity in patients with chronic obstructive pulmonary disease (COPD). We chose the following outcomes: mortality, suicide behaviour, risk of COPD exacerbation, use of primary care and prescription data.

METHODS: A literature review was performed on 16 December 2014 in PubMed, Embase, OVID Medline and Cochrane for cohort studies. Only studies with mortality and exacerbation/hospital admissions were found. Studies failing to meet relevant criteria in terms of design or/and outcome, and studies with... (More)

INTRODUCTION: Patients with depression have significantly increased mortality from somatic disease. The purpose of this article was to review studies that investigate if there is a prognostic association with depression as co-morbidity in patients with chronic obstructive pulmonary disease (COPD). We chose the following outcomes: mortality, suicide behaviour, risk of COPD exacerbation, use of primary care and prescription data.

METHODS: A literature review was performed on 16 December 2014 in PubMed, Embase, OVID Medline and Cochrane for cohort studies. Only studies with mortality and exacerbation/hospital admissions were found. Studies failing to meet relevant criteria in terms of design or/and outcome, and studies with significant methodological faults were excluded.

RESULTS: A total of 22 cohort studies were included. Of these studies, 20 were prospective, one retrospective and one was a combined retro- and prospective study. There was a tendency for studies with more patients and higher methodological quality to show a positive correlation. Sixteen of the studies showed that depression was associated with increased mortality (relative risk (RR): 1.02-3.6) and more COPD exacerbations (RR: 1.3-7.0).

CONCLUSIONS: The results showed that not only is depression a debilitating disease on its own, it also predisposes to COPD exacerbations and increased mortality in patients with COPD. Depression in patients with COPD is under-diagnosed and undertreated, and a stronger focus on the clinical significance of depression as co-morbidity is warranted.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Depression/diagnosis, Disease Progression, Hospitalization, Humans, Prognosis, Pulmonary Disease, Chronic Obstructive/mortality
in
Danish Medical Journal
volume
62
issue
10
pages
5137 - 5137
publisher
Danish Medical Association
ISSN
0011-6092
language
English
LU publication?
no
id
70348a61-7d3d-4891-8e06-2df6571a9214
alternative location
http://ugeskriftet.dk/dmj/depression-associated-poor-prognosis-patients-chronic-obstructive-pulmonary-disease-systematic
date added to LUP
2019-05-27 10:35:21
date last changed
2019-05-29 16:22:41
@article{70348a61-7d3d-4891-8e06-2df6571a9214,
  abstract     = {<p>INTRODUCTION: Patients with depression have significantly increased mortality from somatic disease. The purpose of this article was to review studies that investigate if there is a prognostic association with depression as co-morbidity in patients with chronic obstructive pulmonary disease (COPD). We chose the following outcomes: mortality, suicide behaviour, risk of COPD exacerbation, use of primary care and prescription data.</p><p>METHODS: A literature review was performed on 16 December 2014 in PubMed, Embase, OVID Medline and Cochrane for cohort studies. Only studies with mortality and exacerbation/hospital admissions were found. Studies failing to meet relevant criteria in terms of design or/and outcome, and studies with significant methodological faults were excluded.</p><p>RESULTS: A total of 22 cohort studies were included. Of these studies, 20 were prospective, one retrospective and one was a combined retro- and prospective study. There was a tendency for studies with more patients and higher methodological quality to show a positive correlation. Sixteen of the studies showed that depression was associated with increased mortality (relative risk (RR): 1.02-3.6) and more COPD exacerbations (RR: 1.3-7.0).</p><p>CONCLUSIONS: The results showed that not only is depression a debilitating disease on its own, it also predisposes to COPD exacerbations and increased mortality in patients with COPD. Depression in patients with COPD is under-diagnosed and undertreated, and a stronger focus on the clinical significance of depression as co-morbidity is warranted.</p>},
  author       = {Salte, Kim and Titlestad, Ingrid and Halling, Anders},
  issn         = {0011-6092},
  keyword      = {Depression/diagnosis,Disease Progression,Hospitalization,Humans,Prognosis,Pulmonary Disease, Chronic Obstructive/mortality},
  language     = {eng},
  number       = {10},
  pages        = {5137--5137},
  publisher    = {Danish Medical Association},
  series       = {Danish Medical Journal},
  title        = {Depression is associated with poor prognosis in patients with chronic obstructive pulmonary disease - a systematic review},
  volume       = {62},
  year         = {2015},
}