Data on haplotype-supported immunoglobulin germline gene inference
(2017) In Data in Brief 13. p.620-640- Abstract
Data that defines IGHV (immunoglobulin heavy chain variable) germline gene inference using sequences of IgM-encoding transcriptomes obtained by Illumina MiSeq sequencing technology are described. Such inference is used to establish personalized germline gene sets for in-depth antibody repertoire studies and to detect new antibody germline genes from widely available immunoglobulin-encoding transcriptome data sets. Specifically, the data has been used to validate (Parallel antibody germline gene and haplotype analyses support the validity of immunoglobulin germline gene inference and discovery (DOI: 10.1016/j.molimm.2017.03.012) (Kirik et al., 2017) [1]) the inference process. This was accomplished based on analysis of the inferred... (More)
Data that defines IGHV (immunoglobulin heavy chain variable) germline gene inference using sequences of IgM-encoding transcriptomes obtained by Illumina MiSeq sequencing technology are described. Such inference is used to establish personalized germline gene sets for in-depth antibody repertoire studies and to detect new antibody germline genes from widely available immunoglobulin-encoding transcriptome data sets. Specifically, the data has been used to validate (Parallel antibody germline gene and haplotype analyses support the validity of immunoglobulin germline gene inference and discovery (DOI: 10.1016/j.molimm.2017.03.012) (Kirik et al., 2017) [1]) the inference process. This was accomplished based on analysis of the inferred germline genes’ association to the donors’ different haplotypes as defined by their different, expressed IGHJ alleles and/or IGHD genes/alleles. The data is important for development of validated germline gene databases containing entries inferred from immunoglobulin-encoding transcriptome sequencing data sets, and for generation of valid, personalized antibody germline gene repertoires.
(Less)
- author
- Kirik, Ufuk
LU
; Greiff, Lennart
LU
; Levander, Fredrik
LU
and Ohlin, Mats LU
- organization
- publishing date
- 2017-08-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Antibody, Gene inference, Germline repertoire, Immunoglobulin germline gene, Transcriptome, Validation
- in
- Data in Brief
- volume
- 13
- pages
- 21 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:28725665
- scopus:85021755421
- ISSN
- 2352-3409
- DOI
- 10.1016/j.dib.2017.06.031
- language
- English
- LU publication?
- yes
- id
- 703bd660-903e-43ef-94d0-d5a95efca667
- date added to LUP
- 2017-07-18 13:47:22
- date last changed
- 2025-01-07 17:22:13
@article{703bd660-903e-43ef-94d0-d5a95efca667, abstract = {{<p>Data that defines IGHV (immunoglobulin heavy chain variable) germline gene inference using sequences of IgM-encoding transcriptomes obtained by Illumina MiSeq sequencing technology are described. Such inference is used to establish personalized germline gene sets for in-depth antibody repertoire studies and to detect new antibody germline genes from widely available immunoglobulin-encoding transcriptome data sets. Specifically, the data has been used to validate (Parallel antibody germline gene and haplotype analyses support the validity of immunoglobulin germline gene inference and discovery (DOI: 10.1016/j.molimm.2017.03.012) (Kirik et al., 2017) [1]) the inference process. This was accomplished based on analysis of the inferred germline genes’ association to the donors’ different haplotypes as defined by their different, expressed IGHJ alleles and/or IGHD genes/alleles. The data is important for development of validated germline gene databases containing entries inferred from immunoglobulin-encoding transcriptome sequencing data sets, and for generation of valid, personalized antibody germline gene repertoires.</p>}}, author = {{Kirik, Ufuk and Greiff, Lennart and Levander, Fredrik and Ohlin, Mats}}, issn = {{2352-3409}}, keywords = {{Antibody; Gene inference; Germline repertoire; Immunoglobulin germline gene; Transcriptome; Validation}}, language = {{eng}}, month = {{08}}, pages = {{620--640}}, publisher = {{Elsevier}}, series = {{Data in Brief}}, title = {{Data on haplotype-supported immunoglobulin germline gene inference}}, url = {{http://dx.doi.org/10.1016/j.dib.2017.06.031}}, doi = {{10.1016/j.dib.2017.06.031}}, volume = {{13}}, year = {{2017}}, }