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Data on haplotype-supported immunoglobulin germline gene inference

Kirik, Ufuk LU ; Greiff, Lennart LU ; Levander, Fredrik LU and Ohlin, Mats LU (2017) In Data in brief 13. p.620-640
Abstract

Data that defines IGHV (immunoglobulin heavy chain variable) germline gene inference using sequences of IgM-encoding transcriptomes obtained by Illumina MiSeq sequencing technology are described. Such inference is used to establish personalized germline gene sets for in-depth antibody repertoire studies and to detect new antibody germline genes from widely available immunoglobulin-encoding transcriptome data sets. Specifically, the data has been used to validate (Parallel antibody germline gene and haplotype analyses support the validity of immunoglobulin germline gene inference and discovery (DOI: 10.1016/j.molimm.2017.03.012) (Kirik et al., 2017) [1]) the inference process. This was accomplished based on analysis of the inferred... (More)

Data that defines IGHV (immunoglobulin heavy chain variable) germline gene inference using sequences of IgM-encoding transcriptomes obtained by Illumina MiSeq sequencing technology are described. Such inference is used to establish personalized germline gene sets for in-depth antibody repertoire studies and to detect new antibody germline genes from widely available immunoglobulin-encoding transcriptome data sets. Specifically, the data has been used to validate (Parallel antibody germline gene and haplotype analyses support the validity of immunoglobulin germline gene inference and discovery (DOI: 10.1016/j.molimm.2017.03.012) (Kirik et al., 2017) [1]) the inference process. This was accomplished based on analysis of the inferred germline genes’ association to the donors’ different haplotypes as defined by their different, expressed IGHJ alleles and/or IGHD genes/alleles. The data is important for development of validated germline gene databases containing entries inferred from immunoglobulin-encoding transcriptome sequencing data sets, and for generation of valid, personalized antibody germline gene repertoires.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Antibody, Gene inference, Germline repertoire, Immunoglobulin germline gene, Transcriptome, Validation
in
Data in brief
volume
13
pages
21 pages
external identifiers
  • scopus:85021755421
ISSN
2352-3409
DOI
10.1016/j.dib.2017.06.031
language
English
LU publication?
yes
id
703bd660-903e-43ef-94d0-d5a95efca667
date added to LUP
2017-07-18 13:47:22
date last changed
2017-07-18 13:47:22
@article{703bd660-903e-43ef-94d0-d5a95efca667,
  abstract     = {<p>Data that defines IGHV (immunoglobulin heavy chain variable) germline gene inference using sequences of IgM-encoding transcriptomes obtained by Illumina MiSeq sequencing technology are described. Such inference is used to establish personalized germline gene sets for in-depth antibody repertoire studies and to detect new antibody germline genes from widely available immunoglobulin-encoding transcriptome data sets. Specifically, the data has been used to validate (Parallel antibody germline gene and haplotype analyses support the validity of immunoglobulin germline gene inference and discovery (DOI: 10.1016/j.molimm.2017.03.012) (Kirik et al., 2017) [1]) the inference process. This was accomplished based on analysis of the inferred germline genes’ association to the donors’ different haplotypes as defined by their different, expressed IGHJ alleles and/or IGHD genes/alleles. The data is important for development of validated germline gene databases containing entries inferred from immunoglobulin-encoding transcriptome sequencing data sets, and for generation of valid, personalized antibody germline gene repertoires.</p>},
  author       = {Kirik, Ufuk and Greiff, Lennart and Levander, Fredrik and Ohlin, Mats},
  issn         = {2352-3409},
  keyword      = {Antibody,Gene inference,Germline repertoire,Immunoglobulin germline gene,Transcriptome,Validation},
  language     = {eng},
  month        = {08},
  pages        = {620--640},
  series       = {Data in brief},
  title        = {Data on haplotype-supported immunoglobulin germline gene inference},
  url          = {http://dx.doi.org/10.1016/j.dib.2017.06.031},
  volume       = {13},
  year         = {2017},
}