Longitudinal Tau PET Using 18F-Flortaucipir : The Effect of Relative Cerebral Blood Flow on Quantitative and Semiquantitative Parameters
(2023) In Journal of nuclear medicine : official publication, Society of Nuclear Medicine 64(2). p.281-286- Abstract
Semiquantitative PET measures such as SUV ratio (SUVr) have several advantages over quantitative measures, such as practical applicability and relative computational simplicity. However, SUVr may potentially be affected by changes in blood flow, whereas quantitative measures such as nondisplaceable binding potential (BPND) are not. For 18F-flortaucipir PET, the sensitivity of SUVr for changes in blood flow is currently unknown. Therefore, we compared semiquantitative (SUVr) and quantitative (BPND) parameters of longitudinal 18F-flortaucipir PET scans and assessed their vulnerability to changes in blood flow. Methods: Subjects with subjective cognitive decline (n = 38) and Alzheimer disease patients (n = 24) underwent baseline and 2-y... (More)
Semiquantitative PET measures such as SUV ratio (SUVr) have several advantages over quantitative measures, such as practical applicability and relative computational simplicity. However, SUVr may potentially be affected by changes in blood flow, whereas quantitative measures such as nondisplaceable binding potential (BPND) are not. For 18F-flortaucipir PET, the sensitivity of SUVr for changes in blood flow is currently unknown. Therefore, we compared semiquantitative (SUVr) and quantitative (BPND) parameters of longitudinal 18F-flortaucipir PET scans and assessed their vulnerability to changes in blood flow. Methods: Subjects with subjective cognitive decline (n = 38) and Alzheimer disease patients (n = 24) underwent baseline and 2-y follow-up dynamic 18F-flortaucipir PET scans. BPND and relative tracer delivery were estimated using receptor parametric mapping, and SUVr at 80-100 min was calculated. Regional SUVrs were compared with corresponding distribution volume ratio (BPND + 1) using paired t tests. Additionally, simulations were performed to model effects of larger flow changes in different binding categories. Results: Results in subjective cognitive decline and Alzheimer disease showed only minor differences between SUVr and BPND changes over time. Relative tracer delivery changes were small in all groups. Simulations illustrated a variable bias for SUVr depending on the amount of binding. Conclusion: SUVr provided an accurate estimate of changes in specific binding for 18F-flortaucipir over a 2-y follow-up during which changes in flow were small. Notwithstanding, simulations showed that large(r) flow changes may affect 18F-flortaucipir SUVr. Given that it is currently unknown to what order of magnitude pharmacotherapeutic interventions may induce changes in cerebral blood flow, caution may be warranted when changes in flow are potentially large(r), as in clinical trials.
(Less)
- author
- organization
- publishing date
- 2023-02-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alzheimer disease, dynamic (DVR/BPND), longitudinal 18F-flortaucipir PET, quantification, static (SUVr)
- in
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
- volume
- 64
- issue
- 2
- pages
- 6 pages
- publisher
- Society of Nuclear Medicine
- external identifiers
-
- pmid:36265910
- scopus:85147317671
- ISSN
- 0161-5505
- DOI
- 10.2967/jnumed.122.263926
- language
- English
- LU publication?
- yes
- id
- 70532ecb-f6f8-41a6-aa68-a263affe38c7
- date added to LUP
- 2023-02-23 14:12:03
- date last changed
- 2024-04-18 19:03:24
@article{70532ecb-f6f8-41a6-aa68-a263affe38c7,
abstract = {{<p>Semiquantitative PET measures such as SUV ratio (SUVr) have several advantages over quantitative measures, such as practical applicability and relative computational simplicity. However, SUVr may potentially be affected by changes in blood flow, whereas quantitative measures such as nondisplaceable binding potential (BPND) are not. For 18F-flortaucipir PET, the sensitivity of SUVr for changes in blood flow is currently unknown. Therefore, we compared semiquantitative (SUVr) and quantitative (BPND) parameters of longitudinal 18F-flortaucipir PET scans and assessed their vulnerability to changes in blood flow. Methods: Subjects with subjective cognitive decline (n = 38) and Alzheimer disease patients (n = 24) underwent baseline and 2-y follow-up dynamic 18F-flortaucipir PET scans. BPND and relative tracer delivery were estimated using receptor parametric mapping, and SUVr at 80-100 min was calculated. Regional SUVrs were compared with corresponding distribution volume ratio (BPND + 1) using paired t tests. Additionally, simulations were performed to model effects of larger flow changes in different binding categories. Results: Results in subjective cognitive decline and Alzheimer disease showed only minor differences between SUVr and BPND changes over time. Relative tracer delivery changes were small in all groups. Simulations illustrated a variable bias for SUVr depending on the amount of binding. Conclusion: SUVr provided an accurate estimate of changes in specific binding for 18F-flortaucipir over a 2-y follow-up during which changes in flow were small. Notwithstanding, simulations showed that large(r) flow changes may affect 18F-flortaucipir SUVr. Given that it is currently unknown to what order of magnitude pharmacotherapeutic interventions may induce changes in cerebral blood flow, caution may be warranted when changes in flow are potentially large(r), as in clinical trials.</p>}},
author = {{Visser, Denise and Tuncel, Hayel and Ossenkoppele, Rik and Yaqub, Maqsood and Wolters, Emma E. and Timmers, Tessa and Weltings, Emma and Coomans, Emma M. and den Hollander, Marijke E. and van der Flier, Wiesje M. and van Berckel, Bart N.M. and Golla, Sandeep S.V.}},
issn = {{0161-5505}},
keywords = {{Alzheimer disease; dynamic (DVR/BPND); longitudinal 18F-flortaucipir PET; quantification; static (SUVr)}},
language = {{eng}},
month = {{02}},
number = {{2}},
pages = {{281--286}},
publisher = {{Society of Nuclear Medicine}},
series = {{Journal of nuclear medicine : official publication, Society of Nuclear Medicine}},
title = {{Longitudinal Tau PET Using <sup>18</sup>F-Flortaucipir : The Effect of Relative Cerebral Blood Flow on Quantitative and Semiquantitative Parameters}},
url = {{http://dx.doi.org/10.2967/jnumed.122.263926}},
doi = {{10.2967/jnumed.122.263926}},
volume = {{64}},
year = {{2023}},
}