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Animal models of neurodegenerative disease: Insights from in vivo imaging studies

Strome, Elissa LU and Doudet, D. J. (2007) In Molecular Imaging and Biology 9(4). p.186-195
Abstract
Animal models have been used extensively to understand the etiology and pathophysiology of human neurodegenerative diseases, and are an essential component in the development of therapeutic interventions for these disorders. In recent years, technical advances in imaging modalities such as positron emission tomography (PET) and magnetic resonance imaging (MRI) have allowed the use of these techniques for the evaluation of functional, neurochemical, and anatomical changes in the brains of animals. Combining animal models of neurodegenerative disorders with neuroimaging provides a powerful tool to follow the disease process, to examine compensatory mechanisms, and to investigate the effects of potential treatments preclinically to derive... (More)
Animal models have been used extensively to understand the etiology and pathophysiology of human neurodegenerative diseases, and are an essential component in the development of therapeutic interventions for these disorders. In recent years, technical advances in imaging modalities such as positron emission tomography (PET) and magnetic resonance imaging (MRI) have allowed the use of these techniques for the evaluation of functional, neurochemical, and anatomical changes in the brains of animals. Combining animal models of neurodegenerative disorders with neuroimaging provides a powerful tool to follow the disease process, to examine compensatory mechanisms, and to investigate the effects of potential treatments preclinically to derive knowledge that will ultimately inform our clinical decisions. This article reviews the literature on the use of PET and MRI in animal models of Parkinson's disease, Huntington's disease, and Alzheimer's disease, and evaluates the strengths and limitations of brain imaging in animal models of neurodegenerative diseases. (Less)
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
PARKINSONS-DISEASE, OPIATE RECEPTOR AVIDITY, MPTP-TREATED, ALZHEIMERS-DISEASE, HUNTINGTONS-DISEASE, PRIMATE MODEL, TRANSGENIC MOUSE MODEL, LESIONED RHESUS-MONKEYS, POSITRON-EMISSION-TOMOGRAPHY, MAGNETIC-RESONANCE-SPECTROSCOPY, MONKEYS
in
Molecular Imaging and Biology
volume
9
issue
4
pages
186 - 195
publisher
Springer Science and Business Media B.V.
external identifiers
  • wos:000247914400004
  • scopus:34447095438
ISSN
1536-1632
DOI
10.1007/s11307-007-0093-4
language
English
LU publication?
yes
id
7055dd09-1591-43cc-8bd8-ce5424805d23 (old id 1417912)
date added to LUP
2016-04-01 12:16:12
date last changed
2025-04-04 15:08:29
@article{7055dd09-1591-43cc-8bd8-ce5424805d23,
  abstract     = {{Animal models have been used extensively to understand the etiology and pathophysiology of human neurodegenerative diseases, and are an essential component in the development of therapeutic interventions for these disorders. In recent years, technical advances in imaging modalities such as positron emission tomography (PET) and magnetic resonance imaging (MRI) have allowed the use of these techniques for the evaluation of functional, neurochemical, and anatomical changes in the brains of animals. Combining animal models of neurodegenerative disorders with neuroimaging provides a powerful tool to follow the disease process, to examine compensatory mechanisms, and to investigate the effects of potential treatments preclinically to derive knowledge that will ultimately inform our clinical decisions. This article reviews the literature on the use of PET and MRI in animal models of Parkinson's disease, Huntington's disease, and Alzheimer's disease, and evaluates the strengths and limitations of brain imaging in animal models of neurodegenerative diseases.}},
  author       = {{Strome, Elissa and Doudet, D. J.}},
  issn         = {{1536-1632}},
  keywords     = {{PARKINSONS-DISEASE; OPIATE RECEPTOR AVIDITY; MPTP-TREATED; ALZHEIMERS-DISEASE; HUNTINGTONS-DISEASE; PRIMATE MODEL; TRANSGENIC MOUSE MODEL; LESIONED RHESUS-MONKEYS; POSITRON-EMISSION-TOMOGRAPHY; MAGNETIC-RESONANCE-SPECTROSCOPY; MONKEYS}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{186--195}},
  publisher    = {{Springer Science and Business Media B.V.}},
  series       = {{Molecular Imaging and Biology}},
  title        = {{Animal models of neurodegenerative disease: Insights from in vivo imaging studies}},
  url          = {{http://dx.doi.org/10.1007/s11307-007-0093-4}},
  doi          = {{10.1007/s11307-007-0093-4}},
  volume       = {{9}},
  year         = {{2007}},
}