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Chiral Separation of Amino Acids by Ligand-Exchange Electrochromatography Using Continuous Beds

Schmid, Martin G. ; Grobuschek, Nina ; Tuscher, Claudia ; Gübitz, Gerald ; Végvári, Ákos LU ; Machtejevas, Egidijus ; Maruska, Audrius and Hjertén, Stellan (2000) In Electrophoresis 21(15). p.3141-3144
Abstract
A chiral ligand-exchange phase for capillary electrochromatography based on continu-ous bed technology was developed. The chiral stationary phase is prepared by a one- step in situ copolymerization procedure using methacrylamide, piperazine diacryla- mide, vinylsulfonic acid and N-(2-hydroxy-3-allyloxypropyl)-L-4-hydroxyproline. These chiral continuous beds are inexpensive and easy to prepare. They also have several advantages over silica-based packed capillaries. Since the bed is covalently attached to the capillary wall, no frit is required. The applicability of this new approach to the chi- ral separation of underivatized amino acids is demonstrated.
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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Capillary electrochromatography, Enantiomer separation, Ligand-exchange, Continuous beds, Chiral beds, Monolithic phases
in
Electrophoresis
volume
21
issue
15
pages
3141 - 3144
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:0033799750
ISSN
0173-0835
DOI
10.1002/1522-2683(20000901)21:15<3141::AID-ELPS3141>3.0.CO;2-T
language
English
LU publication?
no
id
707df937-78de-4aab-b459-eed16410d3c1 (old id 3516318)
date added to LUP
2016-04-04 08:56:23
date last changed
2022-03-15 17:21:46
@article{707df937-78de-4aab-b459-eed16410d3c1,
  abstract     = {{A chiral ligand-exchange phase for capillary electrochromatography based on continu-ous bed technology was developed. The chiral stationary phase is prepared by a one- step in situ copolymerization procedure using methacrylamide, piperazine diacryla- mide, vinylsulfonic acid and N-(2-hydroxy-3-allyloxypropyl)-L-4-hydroxyproline. These chiral continuous beds are inexpensive and easy to prepare. They also have several advantages over silica-based packed capillaries. Since the bed is covalently attached to the capillary wall, no frit is required. The applicability of this new approach to the chi- ral separation of underivatized amino acids is demonstrated.}},
  author       = {{Schmid, Martin G. and Grobuschek, Nina and Tuscher, Claudia and Gübitz, Gerald and Végvári, Ákos and Machtejevas, Egidijus and Maruska, Audrius and Hjertén, Stellan}},
  issn         = {{0173-0835}},
  keywords     = {{Capillary electrochromatography; Enantiomer separation; Ligand-exchange; Continuous beds; Chiral beds; Monolithic phases}},
  language     = {{eng}},
  number       = {{15}},
  pages        = {{3141--3144}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Electrophoresis}},
  title        = {{Chiral Separation of Amino Acids by Ligand-Exchange Electrochromatography Using Continuous Beds}},
  url          = {{http://dx.doi.org/10.1002/1522-2683(20000901)21:15<3141::AID-ELPS3141>3.0.CO;2-T}},
  doi          = {{10.1002/1522-2683(20000901)21:15<3141::AID-ELPS3141>3.0.CO;2-T}},
  volume       = {{21}},
  year         = {{2000}},
}