Is there a relationship between abdominal aortic aneurysms and alpha1-antitrypsin deficiency (PiZ)?
(1999) In European Journal of Vascular and Endovascular Surgery 17(2). p.149-154- Abstract
- OBJECTIVE: To determine if the frequency of alpha 1AT deficiency (PiZ) is increased in patients with abdominal aortic aneurysm (AAA), and, to investigate whether aneurysmal stiffness and other clinical characteristics differ in AAA patients with and without alpha 1AT deficiency. METHODS: We identified alpha 1AT-deficient individuals by a monoclonal-antibody ELISA technique, in 102 consecutive patients with AAA. Positive ELISA samples were further phenotyped by isoelectric focusing to differentiate between the heterozygosity (PiZ) and homozygosity (PiZZ) state. Aneurysmal diameter and stiffness was measured using echotracking sonography and blood pressure measurements. RESULTS: The frequency of heterozygous alpha 1AT deficiency (PiZ) in... (More)
- OBJECTIVE: To determine if the frequency of alpha 1AT deficiency (PiZ) is increased in patients with abdominal aortic aneurysm (AAA), and, to investigate whether aneurysmal stiffness and other clinical characteristics differ in AAA patients with and without alpha 1AT deficiency. METHODS: We identified alpha 1AT-deficient individuals by a monoclonal-antibody ELISA technique, in 102 consecutive patients with AAA. Positive ELISA samples were further phenotyped by isoelectric focusing to differentiate between the heterozygosity (PiZ) and homozygosity (PiZZ) state. Aneurysmal diameter and stiffness was measured using echotracking sonography and blood pressure measurements. RESULTS: The frequency of heterozygous alpha 1AT deficiency (PiZ) in patients with AAA was similar to that in the general population (6.8% and 4.7%, respectively, p > 0.3). The frequency of popliteal and femoral aneurysm was similar in male PiZ-carriers and non-carriers with AAA, as were age at diagnosis of AAA, aneurysmal diameter, aneurysmal stiffness, and presence of factors that may be associated with AAA (i.e. smoking, hypertension, diabetes mellitus, and family history of AAA). Occurrence of ischaemic heart disease was more frequent in male non-PiZ-carriers than in male PiZ-carriers with AAA (p = 0.03). CONCLUSIONS: The frequency of alpha 1AT deficiency (PiZ) was not increased in our series of patients with AAA and patients in whom the two disorders coexisted did not appear to have different clinical characteristics except for the lower occurrence of ischaemic heart disease among the PiZ-carriers. (Less)
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https://lup.lub.lu.se/record/1115310
- author
- Elzouki, A N ; Rydén Ahlgren, Åsa LU ; Länne, T ; Sonesson, Björn LU and Eriksson, S
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alpha 1-antitrypsin deficiency, Aortic aneurysms
- in
- European Journal of Vascular and Endovascular Surgery
- volume
- 17
- issue
- 2
- pages
- 149 - 154
- publisher
- Elsevier
- external identifiers
-
- pmid:10063411
- scopus:0033082840
- ISSN
- 1532-2165
- DOI
- 10.1053/ejvs.1998.0740
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Clinical Physiology and Nuclear Medicine Unit (013242320)
- id
- 70a09251-8868-4e22-aeb9-b627fb33ad08 (old id 1115310)
- date added to LUP
- 2016-04-01 17:12:54
- date last changed
- 2023-09-05 09:17:02
@article{70a09251-8868-4e22-aeb9-b627fb33ad08, abstract = {{OBJECTIVE: To determine if the frequency of alpha 1AT deficiency (PiZ) is increased in patients with abdominal aortic aneurysm (AAA), and, to investigate whether aneurysmal stiffness and other clinical characteristics differ in AAA patients with and without alpha 1AT deficiency. METHODS: We identified alpha 1AT-deficient individuals by a monoclonal-antibody ELISA technique, in 102 consecutive patients with AAA. Positive ELISA samples were further phenotyped by isoelectric focusing to differentiate between the heterozygosity (PiZ) and homozygosity (PiZZ) state. Aneurysmal diameter and stiffness was measured using echotracking sonography and blood pressure measurements. RESULTS: The frequency of heterozygous alpha 1AT deficiency (PiZ) in patients with AAA was similar to that in the general population (6.8% and 4.7%, respectively, p > 0.3). The frequency of popliteal and femoral aneurysm was similar in male PiZ-carriers and non-carriers with AAA, as were age at diagnosis of AAA, aneurysmal diameter, aneurysmal stiffness, and presence of factors that may be associated with AAA (i.e. smoking, hypertension, diabetes mellitus, and family history of AAA). Occurrence of ischaemic heart disease was more frequent in male non-PiZ-carriers than in male PiZ-carriers with AAA (p = 0.03). CONCLUSIONS: The frequency of alpha 1AT deficiency (PiZ) was not increased in our series of patients with AAA and patients in whom the two disorders coexisted did not appear to have different clinical characteristics except for the lower occurrence of ischaemic heart disease among the PiZ-carriers.}}, author = {{Elzouki, A N and Rydén Ahlgren, Åsa and Länne, T and Sonesson, Björn and Eriksson, S}}, issn = {{1532-2165}}, keywords = {{Alpha 1-antitrypsin deficiency; Aortic aneurysms}}, language = {{eng}}, number = {{2}}, pages = {{149--154}}, publisher = {{Elsevier}}, series = {{European Journal of Vascular and Endovascular Surgery}}, title = {{Is there a relationship between abdominal aortic aneurysms and alpha1-antitrypsin deficiency (PiZ)?}}, url = {{http://dx.doi.org/10.1053/ejvs.1998.0740}}, doi = {{10.1053/ejvs.1998.0740}}, volume = {{17}}, year = {{1999}}, }